Somatostatin receptor 5

Somatostatin receptor 5
Identifiers
Symbols	SSTR5 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20287
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SSTR5 214555 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Somatostatin receptor 5, also known as SSTR5, is a human gene.

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR5 is a member of the superfamily of receptors having seven transmembrane segments.

See also

• Somatostatin receptor

Further reading

• Yamada Y, Post SR, Wang K; et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. PMID 1346068.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Montminy MR, Goodman RH, Horovitch SJ, Habener JF (1984). "Primary structure of the gene encoding rat preprosomatostatin". Proc. Natl. Acad. Sci. U.S.A. 81 (11): 3337–40. PMID 6145156.CS1 maint: Multiple names: authors list (link)
• Takeda J, Fernald AA, Yamagata K; et al. (1995). "Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization". Genomics. 26 (3): 638–9. PMID 7607700.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Panetta R, Greenwood MT, Warszynska A; et al. (1994). "Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28". Mol. Pharmacol. 45 (3): 417–27. PMID 7908405.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• O'Carroll AM, Raynor K, Lolait SJ, Reisine T (1994). "Characterization of cloned human somatostatin receptor SSTR5". Mol. Pharmacol. 46 (2): 291–8. PMID 8078491.CS1 maint: Multiple names: authors list (link)
• Yamada Y, Kagimoto S, Kubota A; et al. (1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype". Biochem. Biophys. Res. Commun. 195 (2): 844–52. PMID 8373420.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamada Y, Stoffel M, Espinosa R; et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukusumi S, Kitada C, Takekawa S; et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ain KB, Taylor KD, Tofiq S, Venkataraman G (1997). "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines". J. Clin. Endocrinol. Metab. 82 (6): 1857–62. PMID 9177396.CS1 maint: Multiple names: authors list (link)
• de Lecea L, Ruiz-Lozano P, Danielson PE; et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jaïs P, Terris B, Ruszniewski P; et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". Eur. J. Clin. Invest. 27 (8): 639–44. PMID 9279525.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hukovic N, Panetta R, Kumar U; et al. (1998). "The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization". J. Biol. Chem. 273 (33): 21416–22. PMID 9694905.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Mol. Endocrinol. 13 (1): 82–90. PMID 9892014.CS1 maint: Multiple names: authors list (link)
• Kumar U, Sasi R, Suresh S; et al. (1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis". Diabetes. 48 (1): 77–85. PMID 9892225.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rocheville M, Lange DC, Kumar U; et al. (2000). "Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers". J. Biol. Chem. 275 (11): 7862–9. PMID 10713101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rocheville M, Lange DC, Kumar U; et al. (2000). "Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity". Science. 288 (5463): 154–7. PMID 10753124.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Daniels RJ, Peden JF, Lloyd C; et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. PMID 11157797.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ballarè E, Persani L, Lania AG; et al. (2001). "Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment". J. Clin. Endocrinol. Metab. 86 (8): 3809–14. PMID 11502816.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pasquali D, Notaro A, Esposito D; et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Papotti M, Bongiovanni M, Volante M; et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Arch. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• IUPHAR Receptor Database - Somatostatin Receptors
• somatostatin+receptor+5 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:WikiDoc Sources