Glucagon-like peptide 1 receptor

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Glucagon-like peptide 1 receptor
Identifiers
Symbols GLP1R ; MGC138331
External IDs Template:OMIM5 Template:MGI HomoloGene: 1558
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The gene for the glucagon-like peptide 1 receptor (GLP-1) receptor is on chromosome 6 and is known to be expressed in pancreatic beta cells.[1]

See also

References

  1. ↑ Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors" (PDF). Recept. Channels. 8 (3–4): 179–88. PMID 12529935. Retrieved 2007-08-24.

Further reading

  • van Eyll B, Lankat-Buttgereit B, Bode HP; et al. (1994). "Signal transduction of the GLP-1-receptor cloned from a human insulinoma". FEBS Lett. 348 (1): 7–13. PMID 7517895.
  • Gromada J, Rorsman P, Dissing S, Wulff BS (1995). "Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release". FEBS Lett. 373 (2): 182–6. PMID 7589461.
  • Wei Y, Mojsov S (1995). "Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences". FEBS Lett. 358 (3): 219–24. PMID 7843404.
  • Lankat-Buttgereit B, Göke R, Stöckmann F; et al. (1994). "Detection of the human glucagon-like peptide 1(7-36) amide receptor on insulinoma-derived cell membranes". Digestion. 55 (1): 29–33. PMID 8112494.
  • Graziano MP, Hey PJ, Borkowski D; et al. (1993). "Cloning and functional expression of a human glucagon-like peptide-1 receptor". Biochem. Biophys. Res. Commun. 196 (1): 141–6. doi:10.1006/bbrc.1993.2226. PMID 8216285.
  • Stoffel M, Espinosa R, Le Beau MM, Bell GI (1993). "Human glucagon-like peptide-1 receptor gene. Localization to chromosome band 6p21 by fluorescence in situ hybridization and linkage of a highly polymorphic simple tandem repeat DNA polymorphism to other markers on chromosome 6". Diabetes. 42 (8): 1215–8. PMID 8392011.
  • Dillon JS, Tanizawa Y, Wheeler MB; et al. (1993). "Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor". Endocrinology. 133 (4): 1907–10. PMID 8404634.
  • Thorens B, Porret A, Bühler L; et al. (1993). "Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor". Diabetes. 42 (11): 1678–82. PMID 8405712.
  • Lankat-Buttgereit B, Göke B (1997). "Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene". Peptides. 18 (5): 617–24. PMID 9213353.
  • Frimurer TM, Bywater RP (1999). "Structure of the integral membrane domain of the GLP1 receptor". Proteins. 35 (4): 375–86. PMID 10382665.
  • Huypens P, Ling Z, Pipeleers D, Schuit F (2001). "Glucagon receptors on human islet cells contribute to glucose competence of insulin release". Diabetologia. 43 (8): 1012–9. PMID 10990079.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
  • Xiao Q, Jeng W, Wheeler MB (2001). "Characterization of glucagon-like peptide-1 receptor-binding determinants". J. Mol. Endocrinol. 25 (3): 321–35. PMID 11116211.
  • Bazarsuren A, Grauschopf U, Wozny M; et al. (2003). "In vitro folding, functional characterization, and disulfide pattern of the extracellular domain of human GLP-1 receptor". Biophys. Chem. 96 (2–3): 305–18. PMID 12034449.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Tokuyama Y, Matsui K, Egashira T; et al. (2005). "Five missense mutations in glucagon-like peptide 1 receptor gene in Japanese population". Diabetes Res. Clin. Pract. 66 (1): 63–9. doi:10.1016/j.diabres.2004.02.004. PMID 15364163.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Jorgensen R, Martini L, Schwartz TW, Elling CE (2005). "Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype". Mol. Endocrinol. 19 (3): 812–23. doi:10.1210/me.2004-0312. PMID 15528268.
  • Mahon MJ, Shimada M (2005). "Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors". FEBS Lett. 579 (3): 803–7. doi:10.1016/j.febslet.2004.12.056. PMID 15670850.

External links

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