P2Y12

	WikiDoc Resources for P2Y12
Articles
Most recent articles on P2Y12 Most cited articles on P2Y12 Review articles on P2Y12 Articles on P2Y12 in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on P2Y12 Images of P2Y12 Photos of P2Y12 Podcasts & MP3s on P2Y12 Videos on P2Y12
Evidence Based Medicine
Cochrane Collaboration on P2Y12 Bandolier on P2Y12 TRIP on P2Y12
Clinical Trials
Ongoing Trials on P2Y12 at Clinical Trials.gov Trial results on P2Y12 Clinical Trials on P2Y12 at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on P2Y12 NICE Guidance on P2Y12 NHS PRODIGY Guidance FDA on P2Y12 CDC on P2Y12
Books
Books on P2Y12
News
P2Y12 in the news Be alerted to news on P2Y12 News trends on P2Y12
Commentary
Blogs on P2Y12
Definitions
Definitions of P2Y12
Patient Resources / Community
Patient resources on P2Y12 Discussion groups on P2Y12 Patient Handouts on P2Y12 Directions to Hospitals Treating P2Y12 Risk calculators and risk factors for P2Y12
Healthcare Provider Resources
Symptoms of P2Y12 Causes & Risk Factors for P2Y12 Diagnostic studies for P2Y12 Treatment of P2Y12
Continuing Medical Education (CME)
CME Programs on P2Y12
International
P2Y12 en Espanol P2Y12 en Francais
Business
P2Y12 in the Marketplace Patents on P2Y12
Experimental / Informatics
List of terms related to P2Y12

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

OVerview

In the field of molecular biology, the P2Y₁₂ protein is found mainly but not exclusively on the surface of blood platelets, and is an important regulator in blood clotting.^[1]

P2Y₁₂ belongs to the Gi class of a group of G protein-coupled (GPCR) purinergic receptors^[2] and is a chemoreceptor for adenosine diphosphate (ADP).^[3]^[4] The P2Y family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.^[5]

The drugs clopidogrel (PLAVIX), prasugrel (Efient, Effient), ticagrelor (BRILINTA), and cangrelor bind to this receptor and are marketed as antiplatelet agents.^[3]

↑ Dorsam RT, Kunapuli SP (2004). "Central role of the P2Y12 receptor in platelet activation". J. Clin. Invest. 113 (3): 340–5. doi:10.1172/JCI200420986. PMC 324551. PMID 14755328.
↑ Murugappa S, Kunapuli SP (2006). "The role of ADP receptors in platelet function". Front. Biosci. 11 (1): 1977–86. doi:10.2741/1939. PMID 16368572.
↑ ^3.0 ^3.1 Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, Yang RB, Nurden P, Nurden A, Julius D, Conley PB (2001). "Identification of the platelet ADP receptor targeted by antithrombotic drugs". Nature. 409 (6817): 202–7. doi:10.1038/35051599. PMID 11196645.
↑ Nicholas RA (2001). "Identification of the P2Y(12) receptor: a novel member of the P2Y family of receptors activated by extracellular nucleotides". Mol. Pharmacol. 60 (3): 416–20. PMID 11502870.
↑ "Entrez Gene: P2RY12 purinergic receptor P2Y, G-protein coupled, 12".

"P2Y Receptors: P2Y₁₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
purinoceptor+P2Y12 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.