Cannabinoid receptor 2 (macrophage)

Cannabinoid receptor 2 (macrophage)
Identifiers
Symbols	CNR2 ; CB2; CX5
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1389
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cannabinoid receptor 2 (macrophage), also known as CB2 or CNR2, is a human gene.

The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.

See also

• Cannabinoid receptor

Further reading

• Oddi S, Spagnuolo P, Bari M; et al. (2007). "Differential modulation of type 1 and type 2 cannabinoid receptors along the neuroimmune axis". Int. Rev. Neurobiol. 82: 327–37. doi:10.1016/S0074-7742(07)82017-4. PMID 17678969.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Galiègue S, Mary S, Marchand J; et al. (1995). "Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations". Eur. J. Biochem. 232 (1): 54–61. PMID 7556170.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Munro S, Thomas KL, Abu-Shaar M (1993). "Molecular characterization of a peripheral receptor for cannabinoids". Nature. 365 (6441): 61–5. doi:10.1038/365061a0. PMID 7689702.CS1 maint: Multiple names: authors list (link)
• Shire D, Calandra B, Rinaldi-Carmona M; et al. (1996). "Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor". Biochim. Biophys. Acta. 1307 (2): 132–6. PMID 8679694.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tao Q, McAllister SD, Andreassi J; et al. (1999). "Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity". Mol. Pharmacol. 55 (3): 605–13. PMID 10051546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nong L, Newton C, Friedman H, Klein TW (2002). "CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types". Adv. Exp. Med. Biol. 493: 229–33. PMID 11727770.CS1 maint: Multiple names: authors list (link)
• Ho BY, Current L, Drewett JG (2002). "Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16)". FEBS Lett. 522 (1–3): 130–4. PMID 12095632.CS1 maint: Multiple names: authors list (link)
• Matias I, Pochard P, Orlando P; et al. (2002). "Presence and regulation of the endocannabinoid system in human dendritic cells". Eur. J. Biochem. 269 (15): 3771–8. PMID 12153574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Song ZH, Feng W (2002). "Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function". FEBS Lett. 531 (2): 290–4. PMID 12417328.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Casanova ML, Blázquez C, Martínez-Palacio J; et al. (2003). "Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors". J. Clin. Invest. 111 (1): 43–50. PMID 12511587.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Feng W, Song ZH (2003). "Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor". Biochem. Pharmacol. 65 (7): 1077–85. PMID 12663043.
• Kishimoto S, Gokoh M, Oka S; et al. (2003). "2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism". J. Biol. Chem. 278 (27): 24469–75. doi:10.1074/jbc.M301359200. PMID 12711605.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jorda MA, Rayman N, Valk P; et al. (2003). "Identification, characterization, and function of a novel oncogene: the peripheral cannabinoid receptor Cb2". Ann. N. Y. Acad. Sci. 996: 10–6. PMID 12799277.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Benito C, Núñez E, Tolón RM; et al. (2003). "Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains". J. Neurosci. 23 (35): 11136–41. PMID 14657172.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rayman N, Lam KH, Laman JD; et al. (2004). "Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status". J. Immunol. 172 (4): 2111–7. PMID 14764676.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rao GK, Zhang W, Kaminski NE (2004). "Cannabinoid receptor-mediated regulation of intracellular calcium by delta(9)-tetrahydrocannabinol in resting T cells". J. Leukoc. Biol. 75 (5): 884–92. doi:10.1189/jlb.1203638. PMID 14966196.CS1 maint: Multiple names: authors list (link)
• Alberich Jordà M, Rayman N, Tas M; et al. (2004). "The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner". Blood. 104 (2): 526–34. doi:10.1182/blood-2003-12-4357. PMID 15039279.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Núñez E, Benito C, Pazos MR; et al. (2004). "Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study". Synapse. 53 (4): 208–13. doi:10.1002/syn.20050. PMID 15266552.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gokoh M, Kishimoto S, Oka S; et al. (2005). "2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells". Biochem. J. 386 (Pt 3): 583–9. doi:10.1042/BJ20041163. PMID 15456404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.