F2RL1

Coagulation factor II (thrombin) receptor-like 1
Identifiers
Symbols	F2RL1 ; GPR11; PAR2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21087
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Coagulation factor II (thrombin) receptor-like 1, also known as F2RL1 or protease activated receptor 2 (PAR2), is a human gene.

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.

See also

• Protease-activated receptor

Further reading

• Kunzelmann K, Schreiber R, König J, Mall M (2003). "Ion transport induced by proteinase-activated receptors (PAR2) in colon and airways". Cell Biochem. Biophys. 36 (2–3): 209–14. PMID 12139406.CS1 maint: Multiple names: authors list (link)
• Kawabata A (2004). "PAR-2: structure, function and relevance to human diseases of the gastric mucosa". Expert reviews in molecular medicine. 4 (16): 1–17. doi:doi:10.1017/S1462399402004799 . PMID 14585156.
• Bushell T (2007). "The emergence of proteinase-activated receptor-2 as a novel target for the treatment of inflammation-related CNS disorders". J. Physiol. (Lond.). 581 (Pt 1): 7–16. doi:10.1113/jphysiol.2007.129577. PMID 17347265.
• Nystedt S, Emilsson K, Larsson AK; et al. (1995). "Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2". Eur. J. Biochem. 232 (1): 84–9. PMID 7556175.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Santulli RJ, Derian CK, Darrow AL; et al. (1995). "Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes". Proc. Natl. Acad. Sci. U.S.A. 92 (20): 9151–5. PMID 7568091.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nystedt S, Emilsson K, Wahlestedt C, Sundelin J (1994). "Molecular cloning of a potential proteinase activated receptor". Proc. Natl. Acad. Sci. U.S.A. 91 (20): 9208–12. PMID 7937743.CS1 maint: Multiple names: authors list (link)
• Mirza H, Yatsula V, Bahou WF (1996). "The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells". J. Clin. Invest. 97 (7): 1705–14. PMID 8601636.CS1 maint: Multiple names: authors list (link)
• Bohm SK, Kong W, Bromme D; et al. (1996). "Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2". Biochem. J. 314 ( Pt 3): 1009–16. PMID 8615752.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Böhm SK, Khitin LM, Grady EF; et al. (1996). "Mechanisms of desensitization and resensitization of proteinase-activated receptor-2". J. Biol. Chem. 271 (36): 22003–16. PMID 8703006.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kahn M, Ishii K, Kuo WL; et al. (1996). "Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster". Mol. Med. 2 (3): 349–57. PMID 8784787.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Molino M, Barnathan ES, Numerof R; et al. (1997). "Interactions of mast cell tryptase with thrombin receptors and PAR-2". J. Biol. Chem. 272 (7): 4043–9. PMID 9020112.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Howells GL, Macey MG, Chinni C; et al. (1997). "Proteinase-activated receptor-2: expression by human neutrophils". J. Cell. Sci. 110 ( Pt 7): 881–7. PMID 9133675.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• D'Andrea MR, Derian CK, Leturcq D; et al. (1998). "Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues". J. Histochem. Cytochem. 46 (2): 157–64. PMID 9446822.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guyonnet Dupérat V, Jacquelin B, Boisseau P; et al. (1998). "Protease-activated receptor genes are clustered on 5q13". Blood. 92 (1): 25–31. PMID 9639495.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Steinhoff M, Corvera CU, Thoma MS; et al. (1999). "Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase". Exp. Dermatol. 8 (4): 282–94. PMID 10439226.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takeuchi T, Harris JL, Huang W; et al. (2000). "Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates". J. Biol. Chem. 275 (34): 26333–42. doi:10.1074/jbc.M002941200. PMID 10831593.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Loew D, Perrault C, Morales M; et al. (2000). "Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry". Biochemistry. 39 (35): 10812–22. PMID 10978167.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Knight DA, Lim S, Scaffidi AK; et al. (2001). "Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma". J. Allergy Clin. Immunol. 108 (5): 797–803. doi:10.1067/mai.2001.119025. PMID 11692107.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miike S, McWilliam AS, Kita H (2002). "Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2". J. Immunol. 167 (11): 6615–22. PMID 11714832.CS1 maint: Multiple names: authors list (link)
• Asokananthan N, Graham PT, Fink J; et al. (2002). "Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells". J. Immunol. 168 (7): 3577–85. PMID 11907122.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.