PTGFR

Prostaglandin F receptor (FP)
Identifiers
Symbols	PTGFR ; FP; MGC120498; MGC46203
External IDs	Template:OMIM5 Template:MGI HomoloGene: 741
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PTGFR 207177 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Prostaglandin F receptor (FP), also known as PTGFR, is a human gene.

The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene.

See also

• Eicosanoid receptor

Further reading

• Duncan AM, Anderson LL, Funk CD; et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family". Genomics. 25 (3): 740–2. PMID 7759114.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lake S, Gullberg H, Wahlqvist J; et al. (1995). "Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor". FEBS Lett. 355 (3): 317–25. PMID 7988697.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bastien L, Sawyer N, Grygorczyk R; et al. (1994). "Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype". J. Biol. Chem. 269 (16): 11873–7. PMID 8163486.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Funk CD, Furci L, FitzGerald GA; et al. (1994). "Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype". J. Biol. Chem. 268 (35): 26767–72. PMID 8253813.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Abramovitz M, Boie Y, Nguyen T; et al. (1994). "Cloning and expression of a cDNA for the human prostanoid FP receptor". J. Biol. Chem. 269 (4): 2632–6. PMID 8300593.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sugimoto Y, Yamasaki A, Segi E; et al. (1997). "Failure of parturition in mice lacking the prostaglandin F receptor". Science. 277 (5326): 681–3. PMID 9235889.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kunapuli P, Lawson JA, Rokach J, FitzGerald GA (1997). "Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha". J. Biol. Chem. 272 (43): 27147–54. PMID 9341156.CS1 maint: Multiple names: authors list (link)
• Betz R, Lagercrantz J, Kedra D; et al. (1999). "Genomic structure, 5' flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene". Biochem. Biophys. Res. Commun. 254 (2): 413–6. doi:10.1006/bbrc.1998.9827. PMID 9918852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kyveris A, Maruscak E, Senchyna M (2002). "Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR". Mol. Vis. 8: 51–8. PMID 11951086.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Neuschäfer-Rube F, Engemaier E, Koch S; et al. (2003). "Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor". Biochem. J. 371 (Pt 2): 443–9. doi:10.1042/BJ20021429. PMID 12519077.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zaragoza DB, Wilson R, Eyster K, Olson DM (2004). "Cloning and characterization of the promoter region of the human prostaglandin F2alpha receptor gene". Biochim. Biophys. Acta. 1676 (2): 193–202. PMID 14746914.CS1 maint: Multiple names: authors list (link)
• Sales KJ, Milne SA, Williams AR; et al. (2004). "Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways". J. Clin. Endocrinol. Metab. 89 (2): 986–93. PMID 14764825.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vielhauer GA, Fujino H, Regan JW (2004). "Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor". Arch. Biochem. Biophys. 421 (2): 175–85. PMID 14984197.CS1 maint: Multiple names: authors list (link)
• Jin P, Fu GK, Wilson AD; et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes". Genomics. 83 (4): 566–71. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sugino N, Karube-Harada A, Taketani T; et al. (2004). "Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation". J. Reprod. Dev. 50 (2): 215–25. PMID 15118249.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scott G, Jacobs S, Leopardi S; et al. (2005). "Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiation". Exp. Cell Res. 304 (2): 407–16. doi:10.1016/j.yexcr.2004.11.016. PMID 15748887.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mandal AK, Ray R, Zhang Z; et al. (2005). "Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators". J. Biol. Chem. 280 (38): 32897–904. doi:10.1074/jbc.M502375200. PMID 16061484.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hébert RL, Carmosino M, Saito O; et al. (2005). "Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct". J. Biol. Chem. 280 (41): 35028–37. doi:10.1074/jbc.M505852200. PMID 16096282.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.