Melanin-concentrating hormone receptor 1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Melanin-concentrating hormone receptor 1''', also known as '''MCH<sub>1</sub>''', is one of the [[melanin-concentrating hormone receptor]]s found in all mammals. <ref name="entrez">{{cite web | title = Entrez Gene: MCHR1 melanin-concentrating hormone receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2847| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = no
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}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds [[Melanin concentrating hormone|melanin-concentrating hormone]]. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to [[somatostatin receptor]]s, this protein does not seem to bind [[somatostatin]].<ref name="entrez" />
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Melanin-concentrating hormone receptor 1
| HGNCid = 4479
| Symbol = MCHR1
| AltSymbols =; GPR24; MCH1R; MGC32129; SLC1
| OMIM = 601751
| ECnumber = 
| Homologene = 21097
| MGIid = 2180756
| GeneAtlas_image1 = PBB_GE_MCHR1_221354_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008188 |text = neuropeptide receptor activity}} {{GNF_GO|id=GO:0030273 |text = melanin-concentrating hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007193 |text = G-protein signaling, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2847
    | Hs_Ensembl = ENSG00000128285
    | Hs_RefseqProtein = NP_005288
    | Hs_RefseqmRNA = NM_005297
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 39405045
    | Hs_GenLoc_end = 39407878
    | Hs_Uniprot = Q99705
    | Mm_EntrezGene = 207911
    | Mm_Ensembl = ENSMUSG00000050164
    | Mm_RefseqmRNA = NM_145132
    | Mm_RefseqProtein = NP_660114
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 81062824
    | Mm_GenLoc_end = 81065367
    | Mm_Uniprot = Q3UY93
  }}
}}
'''Melanin-concentrating hormone receptor 1''', also known as '''MCHR1''', is one of human [[melanin-concentrating hormone receptor]]s.<ref name="entrez">{{cite web | title = Entrez Gene: MCHR1 melanin-concentrating hormone receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2847| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds [[Melanin concentrating hormone|melanin-concentrating hormone]]. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to [[somatostatin receptor]]s, this protein does not seem to bind [[somatostatin]].<ref name="entrez">{{cite web | title = Entrez Gene: MCHR1 melanin-concentrating hormone receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2847| accessdate = }}</ref>
}}


==See also==
MCH<sub>1</sub> is thought to have a number of functions including in the regulation of appetite,<ref name="pmid17655875">{{cite journal | vauthors = Luthin DR | title = Anti-obesity effects of small molecule melanin-concentrating hormone receptor 1 (MCHR1) antagonists | journal = Life Sciences | volume = 81 | issue = 6 | pages = 423–40 | date = Jul 2007 | pmid = 17655875 | doi = 10.1016/j.lfs.2007.05.029 }}</ref><ref name="pmid18393860">{{cite journal | vauthors = Rivera G, Bocanegra-García V, Galiano S, Cirauqui N, Ceras J, Pérez S, Aldana I, Monge A | title = Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity | journal = Current Medicinal Chemistry | volume = 15 | issue = 10 | pages = 1025–43 | year = 2008 | pmid = 18393860 | doi = 10.2174/092986708784049621 }}</ref> and in stress, anxiety and depression.<ref name="pmid12885269">{{cite journal | vauthors = Hervieu G | title = Melanin-concentrating hormone functions in the nervous system: food intake and stress | journal = Expert Opinion on Therapeutic Targets | volume = 7 | issue = 4 | pages = 495–511 | date = Aug 2003 | pmid = 12885269 | doi = 10.1517/14728222.7.4.495 }}</ref><ref name="pmid16999451">{{cite journal | vauthors = Shimazaki T, Yoshimizu T, Chaki S | title = Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders | journal = CNS Drugs | volume = 20 | issue = 10 | pages = 801–11 | year = 2006 | pmid = 16999451 | doi = 10.2165/00023210-200620100-00002 }}</ref><ref name="pmid16548771">{{cite journal | vauthors = Hervieu GJ | title = Further insights into the neurobiology of melanin-concentrating hormone in energy and mood balances | journal = Expert Opinion on Therapeutic Targets | volume = 10 | issue = 2 | pages = 211–29 | date = Apr 2006 | pmid = 16548771 | doi = 10.1517/14728222.10.2.211 }}</ref><ref name="pmid16205780">{{cite journal | vauthors = Smith DG, Davis RJ, Rorick-Kehn L, Morin M, Witkin JM, McKinzie DL, Nomikos GG, Gehlert DR | title = Melanin-concentrating hormone-1 receptor modulates neuroendocrine, behavioral, and corticolimbic neurochemical stress responses in mice | journal = Neuropsychopharmacology | volume = 31 | issue = 6 | pages = 1135–45 | date = Jun 2006 | pmid = 16205780 | doi = 10.1038/sj.npp.1300913 }}</ref><ref name="pmid16934771">{{cite journal | vauthors = Roy M, David N, Cueva M, Giorgetti M | title = A study of the involvement of melanin-concentrating hormone receptor 1 (MCHR1) in murine models of depression | journal = Biological Psychiatry | volume = 61 | issue = 2 | pages = 174–80 | date = Jan 2007 | pmid = 16934771 | doi = 10.1016/j.biopsych.2006.03.076 }}</ref><ref name="pmid18227983">{{cite journal | vauthors = Saito Y, Nagasaki H | title = The melanin-concentrating hormone system and its physiological functions | journal = Results and Problems in Cell Differentiation | volume = 46 | issue =  | pages = 159–79 | year = 2008 | pmid = 18227983 | doi = 10.1007/400_2007_052 | isbn = 978-3-540-78350-3 | series = Results and Problems in Cell Differentiation }}</ref>
 
== Selective ligands ==
 
=== Agonists ===
 
* [[Melanin concentrating hormone]] (MCH)
* S-36057 - modified MCH 6-13 fragment substituted with 3-iodotyrosine at N-terminus via dioxyoctanoyl linker, used as <sup>125</sup>I [[isotopic labeling|radioligand]] for mapping MCH<sub>1</sub> ''in vivo''.<ref name="pmid11375253">{{cite journal | vauthors = Audinot V, Lahaye C, Suply T, Beauverger P, Rodriguez M, Galizzi JP, Fauchère JL, Boutin JA | title = [125I]-S36057: a new and highly potent radioligand for the melanin-concentrating hormone receptor | journal = British Journal of Pharmacology | volume = 133 | issue = 3 | pages = 371–8 | date = Jun 2001 | pmid = 11375253 | pmc = 1572795 | doi = 10.1038/sj.bjp.0704085 }}</ref><ref name="pmid19540226">{{cite journal | vauthors = Able SL, Ivarsson M, Fish RL, Clarke TL, McCourt C, Duckworth JM, Napier C, Katugampola SD | title = Localisation of melanin-concentrating hormone receptor 1 in rat brain and evidence that sleep parameters are not altered despite high central receptor occupancy | journal = European Journal of Pharmacology | volume = 616 | issue = 1-3 | pages = 101–6 | date = Aug 2009 | pmid = 19540226 | doi = 10.1016/j.ejphar.2009.06.009 }}</ref>
 
=== Antagonists ===
 
* ATC-0065
* [[ATC-0175]]<ref name="pmid16614734">{{cite journal | vauthors = Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y | title = ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety | journal = CNS Drug Reviews | volume = 11 | issue = 4 | pages = 341–52 | year = 2005 | pmid = 16614734 | doi = 10.1111/j.1527-3458.2005.tb00052.x }}</ref>
* [[GW-803,430]]<ref name="pmid19182070">{{cite journal | vauthors = Gehlert DR, Rasmussen K, Shaw J, Li X, Ardayfio P, Craft L, Coskun T, Zhang HY, Chen Y, Witkin JM | title = Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 329 | issue = 2 | pages = 429–38 | date = May 2009 | pmid = 19182070 | doi = 10.1124/jpet.108.143362 }}</ref>
* [[NGD-4715]]
* [[SNAP-7941]]<ref name="pmid12783607">{{cite journal | vauthors = Doggrell SA | title = Does the melanin-concentrating hormone antagonist SNAP-7941 deserve 3As? | journal = Expert Opinion on Investigational Drugs | volume = 12 | issue = 6 | pages = 1035–8 | date = Jun 2003 | pmid = 12783607 | doi = 10.1517/13543784.12.6.1035 }}</ref>
* [[SNAP-94847]]<ref name="pmid17237257">{{cite journal | vauthors = David DJ, Klemenhagen KC, Holick KA, Saxe MD, Mendez I, Santarelli L, Craig DA, Zhong H, Swanson CJ, Hegde LG, Ping XI, Dong D, Marzabadi MR, Gerald CP, Hen R | title = Efficacy of the MCHR1 antagonist N-[3-(1-<nowiki/>{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 321 | issue = 1 | pages = 237–48 | date = Apr 2007 | pmid = 17237257 | doi = 10.1124/jpet.106.109678 }}</ref>
* T-226,296<ref name="pmid11909603">{{cite journal | vauthors = Takekawa S, Asami A, Ishihara Y, Terauchi J, Kato K, Shimomura Y, Mori M, Murakoshi H, Kato K, Suzuki N, Nishimura O, Fujino M | title = T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist | journal = European Journal of Pharmacology | volume = 438 | issue = 3 | pages = 129–35 | date = Mar 2002 | pmid = 11909603 | doi = 10.1016/S0014-2999(02)01314-6 }}</ref>
 
== See also ==
*[[Melanin-concentrating hormone receptor]]
*[[Melanin-concentrating hormone receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist|33em}}
==Further reading==
 
{{refbegin | 2}}
== Further reading ==
{{PBB_Further_reading
{{refbegin|33em}}
| citations =
* {{cite journal | vauthors = Kolakowski LF, Jung BP, Nguyen T, Johnson MP, Lynch KR, Cheng R, Heng HH, George SR, O'Dowd BF | title = Characterization of a human gene related to genes encoding somatostatin receptors | journal = FEBS Letters | volume = 398 | issue = 2-3 | pages = 253–8 | date = Dec 1996 | pmid = 8977118 | doi = 10.1016/S0014-5793(96)01160-X }}
*{{cite journal | author=Kolakowski LF, Jung BP, Nguyen T, ''et al.'' |title=Characterization of a human gene related to genes encoding somatostatin receptors. |journal=FEBS Lett. |volume=398 |issue= 2-3 |pages= 253-8 |year= 1997 |pmid= 8977118 |doi= }}
* {{cite journal | vauthors = Chambers J, Ames RS, Bergsma D, Muir A, Fitzgerald LR, Hervieu G, Dytko GM, Foley JJ, Martin J, Liu WS, Park J, Ellis C, Ganguly S, Konchar S, Cluderay J, Leslie R, Wilson S, Sarau HM | title = Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1 | journal = Nature | volume = 400 | issue = 6741 | pages = 261–5 | date = Jul 1999 | pmid = 10421367 | doi = 10.1038/22313 }}
*{{cite journal | author=Chambers J, Ames RS, Bergsma D, ''et al.'' |title=Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. |journal=Nature |volume=400 |issue= 6741 |pages= 261-5 |year= 1999 |pmid= 10421367 |doi= 10.1038/22313 }}
* {{cite journal | vauthors = Saito Y, Nothacker HP, Wang Z, Lin SH, Leslie F, Civelli O | title = Molecular characterization of the melanin-concentrating-hormone receptor | journal = Nature | volume = 400 | issue = 6741 | pages = 265–9 | date = Jul 1999 | pmid = 10421368 | doi = 10.1038/22321 }}
*{{cite journal | author=Saito Y, Nothacker HP, Wang Z, ''et al.'' |title=Molecular characterization of the melanin-concentrating-hormone receptor. |journal=Nature |volume=400 |issue= 6741 |pages= 265-9 |year= 1999 |pmid= 10421368 |doi= 10.1038/22321 }}
* {{cite journal | vauthors = Shimomura Y, Mori M, Sugo T, Ishibashi Y, Abe M, Kurokawa T, Onda H, Nishimura O, Sumino Y, Fujino M | title = Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor | journal = Biochemical and Biophysical Research Communications | volume = 261 | issue = 3 | pages = 622–6 | date = Aug 1999 | pmid = 10441476 | doi = 10.1006/bbrc.1999.1104 }}
*{{cite journal | author=Shimomura Y, Mori M, Sugo T, ''et al.'' |title=Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=261 |issue= 3 |pages= 622-6 |year= 1999 |pmid= 10441476 |doi= 10.1006/bbrc.1999.1104 }}
* {{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | date = Dec 1999 | pmid = 10591208 | doi = 10.1038/990031 }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
* {{cite journal | vauthors = Macdonald D, Murgolo N, Zhang R, Durkin JP, Yao X, Strader CD, Graziano MP | title = Molecular characterization of the melanin-concentrating hormone/receptor complex: identification of critical residues involved in binding and activation | journal = Molecular Pharmacology | volume = 58 | issue = 1 | pages = 217–25 | date = Jul 2000 | pmid = 10860944 | doi =  }}
*{{cite journal | author=Macdonald D, Murgolo N, Zhang R, ''et al.'' |title=Molecular characterization of the melanin-concentrating hormone/receptor complex: identification of critical residues involved in binding and activation. |journal=Mol. Pharmacol. |volume=58 |issue= 1 |pages= 217-25 |year= 2000 |pmid= 10860944 |doi=  }}
* {{cite journal | vauthors = An S, Cutler G, Zhao JJ, Huang SG, Tian H, Li W, Liang L, Rich M, Bakleh A, Du J, Chen JL, Dai K | title = Identification and characterization of a melanin-concentrating hormone receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 13 | pages = 7576–81 | date = Jun 2001 | pmid = 11416225 | pmc = 34710 | doi = 10.1073/pnas.131200698 }}
*{{cite journal | author=An S, Cutler G, Zhao JJ, ''et al.'' |title=Identification and characterization of a melanin-concentrating hormone receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7576-81 |year= 2001 |pmid= 11416225 |doi= 10.1073/pnas.131200698 }}
* {{cite journal | vauthors = Bednarek MA, Feighner SD, Hreniuk DL, Palyha OC, Morin NR, Sadowski SJ, MacNeil DJ, Howard AD, Van der Ploeg LH | title = Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2 | journal = Biochemistry | volume = 40 | issue = 31 | pages = 9379–86 | date = Aug 2001 | pmid = 11478907 | doi = 10.1021/bi010867p }}
*{{cite journal | author=Bednarek MA, Feighner SD, Hreniuk DL, ''et al.'' |title=Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. |journal=Biochemistry |volume=40 |issue= 31 |pages= 9379-86 |year= 2001 |pmid= 11478907 |doi= }}
* {{cite journal | vauthors = Bednarek MA, Tan C, Hreniuk DL, Palyha OC, MacNeil DJ, Van Der Ploeg LH, Howard AD, Feighner SD | title = Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 16 | pages = 13821–6 | date = Apr 2002 | pmid = 11839762 | doi = 10.1074/jbc.M200563200 }}
*{{cite journal | author=Bednarek MA, Tan C, Hreniuk DL, ''et al.'' |title=Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13821-6 |year= 2002 |pmid= 11839762 |doi= 10.1074/jbc.M200563200 }}
* {{cite journal | vauthors = Audinot V, Lahaye C, Suply T, Rovère-Jovène C, Rodriguez M, Nicolas JP, Beauverger P, Cardinaud B, Galizzi JP, Fauchère JL, Nahon JL, Boutin JA | title = SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor | journal = Biochemical and Biophysical Research Communications | volume = 295 | issue = 4 | pages = 841–8 | date = Jul 2002 | pmid = 12127971 | doi = 10.1016/S0006-291X(02)00763-5 }}
*{{cite journal | author=Audinot V, Lahaye C, Suply T, ''et al.'' |title=SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 4 |pages= 841-8 |year= 2002 |pmid= 12127971 |doi= }}
* {{cite journal | vauthors = Hoogduijn MJ, Ancans J, Suzuki I, Estdale S, Thody AJ | title = Melanin-concentrating hormone and its receptor are expressed and functional in human skin | journal = Biochemical and Biophysical Research Communications | volume = 296 | issue = 3 | pages = 698–701 | date = Aug 2002 | pmid = 12176038 | doi = 10.1016/S0006-291X(02)00932-4 }}
*{{cite journal | author=Hoogduijn MJ, Ancans J, Suzuki I, ''et al.'' |title=Melanin-concentrating hormone and its receptor are expressed and functional in human skin. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 3 |pages= 698-701 |year= 2002 |pmid= 12176038 |doi= }}
* {{cite journal | vauthors = Bächner D, Kreienkamp HJ, Richter D | title = MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein | journal = FEBS Letters | volume = 526 | issue = 1-3 | pages = 124–8 | date = Aug 2002 | pmid = 12208518 | doi = 10.1016/S0014-5793(02)03115-0 }}
*{{cite journal | author=Bächner D, Kreienkamp HJ, Richter D |title=MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein. |journal=FEBS Lett. |volume=526 |issue= 1-3 |pages= 124-8 |year= 2002 |pmid= 12208518 |doi= }}
* {{cite journal | vauthors = Verlaet M, Adamantidis A, Coumans B, Chanas G, Zorzi W, Heinen E, Grisar T, Lakaye B | title = Human immune cells express ppMCH mRNA and functional MCHR1 receptor | journal = FEBS Letters | volume = 527 | issue = 1-3 | pages = 205–10 | date = Sep 2002 | pmid = 12220661 | doi = 10.1016/S0014-5793(02)03232-5 }}
*{{cite journal | author=Verlaet M, Adamantidis A, Coumans B, ''et al.'' |title=Human immune cells express ppMCH mRNA and functional MCHR1 receptor. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 205-10 |year= 2002 |pmid= 12220661 |doi= }}
* {{cite journal | vauthors = Logan DW, Bryson-Richardson RJ, Pagán KE, Taylor MS, Currie PD, Jackson IJ | title = The structure and evolution of the melanocortin and MCH receptors in fish and mammals | journal = Genomics | volume = 81 | issue = 2 | pages = 184–91 | date = Feb 2003 | pmid = 12620396 | doi = 10.1016/S0888-7543(02)00037-X }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Pissios P, Trombly DJ, Tzameli I, Maratos-Flier E | title = Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways | journal = Endocrinology | volume = 144 | issue = 8 | pages = 3514–23 | date = Aug 2003 | pmid = 12865333 | doi = 10.1210/en.2002-0004 }}
*{{cite journal | author=Logan DW, Bryson-Richardson RJ, Pagán KE, ''et al.'' |title=The structure and evolution of the melanocortin and MCH receptors in fish and mammals. |journal=Genomics |volume=81 |issue= 2 |pages= 184-91 |year= 2003 |pmid= 12620396 |doi= }}
* {{cite journal | vauthors = Gottumukkala RV, Waterman EA, Herd LM, Gawkrodger DJ, Watson PF, Weetman AP, Kemp EH | title = Autoantibodies in vitiligo patients recognize multiple domains of the melanin-concentrating hormone receptor | journal = The Journal of Investigative Dermatology | volume = 121 | issue = 4 | pages = 765–70 | date = Oct 2003 | pmid = 14632194 | doi = 10.1046/j.1523-1747.2003.12494.x }}
*{{cite journal | author=Pissios P, Trombly DJ, Tzameli I, Maratos-Flier E |title=Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways. |journal=Endocrinology |volume=144 |issue= 8 |pages= 3514-23 |year= 2003 |pmid= 12865333 |doi= }}
* {{cite journal | vauthors = Gibson WT, Pissios P, Trombly DJ, Luan J, Keogh J, Wareham NJ, Maratos-Flier E, O'Rahilly S, Farooqi IS | title = Melanin-concentrating hormone receptor mutations and human obesity: functional analysis | journal = Obesity Research | volume = 12 | issue = 5 | pages = 743–9 | date = May 2004 | pmid = 15166293 | doi = 10.1038/oby.2004.89 }}
*{{cite journal | author=Gottumukkala RV, Waterman EA, Herd LM, ''et al.'' |title=Autoantibodies in vitiligo patients recognize multiple domains of the melanin-concentrating hormone receptor. |journal=J. Invest. Dermatol. |volume=121 |issue= 4 |pages= 765-70 |year= 2003 |pmid= 14632194 |doi= 10.1046/j.1523-1747.2003.12494.x }}
* {{cite journal | vauthors = Hawes BE, Green B, O'Neill K, Fried S, Arreaza MG, Qiu P, Simon JS | title = Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2 | journal = Obesity Research | volume = 12 | issue = 8 | pages = 1327–34 | date = Aug 2004 | pmid = 15340116 | doi = 10.1038/oby.2004.167 }}
*{{cite journal | author=Gibson WT, Pissios P, Trombly DJ, ''et al.'' |title=Melanin-concentrating hormone receptor mutations and human obesity: functional analysis. |journal=Obes. Res. |volume=12 |issue= 5 |pages= 743-9 |year= 2004 |pmid= 15166293 |doi= }}
* {{cite journal | vauthors = Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I | title = A genome annotation-driven approach to cloning the human ORFeome | journal = Genome Biology | volume = 5 | issue = 10 | pages = R84 | year = 2005 | pmid = 15461802 | pmc = 545604 | doi = 10.1186/gb-2004-5-10-r84 }}
*{{cite journal | author=Hawes BE, Green B, O'Neill K, ''et al.'' |title=Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. |journal=Obes. Res. |volume=12 |issue= 8 |pages= 1327-34 |year= 2004 |pmid= 15340116 |doi=  }}
*{{cite journal  | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2998 | title = Melanin-Concentrating Hormone Receptors: MCH<sub>1</sub> | accessdate = | author = | authorlink = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
 
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[[Category:G protein-coupled receptors]]
[[Category:Human proteins]]

Latest revision as of 12:26, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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View/Edit Human

Melanin-concentrating hormone receptor 1, also known as MCH1, is one of the melanin-concentrating hormone receptors found in all mammals. [1]

The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.[1]

Function

MCH1 is thought to have a number of functions including in the regulation of appetite,[2][3] and in stress, anxiety and depression.[4][5][6][7][8][9]

Selective ligands

Agonists

Antagonists

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: MCHR1 melanin-concentrating hormone receptor 1".
  2. ↑ Luthin DR (Jul 2007). "Anti-obesity effects of small molecule melanin-concentrating hormone receptor 1 (MCHR1) antagonists". Life Sciences. 81 (6): 423–40. doi:10.1016/j.lfs.2007.05.029. PMID 17655875.
  3. ↑ Rivera G, Bocanegra-García V, Galiano S, Cirauqui N, Ceras J, Pérez S, Aldana I, Monge A (2008). "Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity". Current Medicinal Chemistry. 15 (10): 1025–43. doi:10.2174/092986708784049621. PMID 18393860.
  4. ↑ Hervieu G (Aug 2003). "Melanin-concentrating hormone functions in the nervous system: food intake and stress". Expert Opinion on Therapeutic Targets. 7 (4): 495–511. doi:10.1517/14728222.7.4.495. PMID 12885269.
  5. ↑ Shimazaki T, Yoshimizu T, Chaki S (2006). "Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders". CNS Drugs. 20 (10): 801–11. doi:10.2165/00023210-200620100-00002. PMID 16999451.
  6. ↑ Hervieu GJ (Apr 2006). "Further insights into the neurobiology of melanin-concentrating hormone in energy and mood balances". Expert Opinion on Therapeutic Targets. 10 (2): 211–29. doi:10.1517/14728222.10.2.211. PMID 16548771.
  7. ↑ Smith DG, Davis RJ, Rorick-Kehn L, Morin M, Witkin JM, McKinzie DL, Nomikos GG, Gehlert DR (Jun 2006). "Melanin-concentrating hormone-1 receptor modulates neuroendocrine, behavioral, and corticolimbic neurochemical stress responses in mice". Neuropsychopharmacology. 31 (6): 1135–45. doi:10.1038/sj.npp.1300913. PMID 16205780.
  8. ↑ Roy M, David N, Cueva M, Giorgetti M (Jan 2007). "A study of the involvement of melanin-concentrating hormone receptor 1 (MCHR1) in murine models of depression". Biological Psychiatry. 61 (2): 174–80. doi:10.1016/j.biopsych.2006.03.076. PMID 16934771.
  9. ↑ Saito Y, Nagasaki H (2008). "The melanin-concentrating hormone system and its physiological functions". Results and Problems in Cell Differentiation. Results and Problems in Cell Differentiation. 46: 159–79. doi:10.1007/400_2007_052. ISBN 978-3-540-78350-3. PMID 18227983.
  10. ↑ Audinot V, Lahaye C, Suply T, Beauverger P, Rodriguez M, Galizzi JP, Fauchère JL, Boutin JA (Jun 2001). "[125I]-S36057: a new and highly potent radioligand for the melanin-concentrating hormone receptor". British Journal of Pharmacology. 133 (3): 371–8. doi:10.1038/sj.bjp.0704085. PMC 1572795. PMID 11375253.
  11. ↑ Able SL, Ivarsson M, Fish RL, Clarke TL, McCourt C, Duckworth JM, Napier C, Katugampola SD (Aug 2009). "Localisation of melanin-concentrating hormone receptor 1 in rat brain and evidence that sleep parameters are not altered despite high central receptor occupancy". European Journal of Pharmacology. 616 (1–3): 101–6. doi:10.1016/j.ejphar.2009.06.009. PMID 19540226.
  12. ↑ Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y (2005). "ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety". CNS Drug Reviews. 11 (4): 341–52. doi:10.1111/j.1527-3458.2005.tb00052.x. PMID 16614734.
  13. ↑ Gehlert DR, Rasmussen K, Shaw J, Li X, Ardayfio P, Craft L, Coskun T, Zhang HY, Chen Y, Witkin JM (May 2009). "Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression". The Journal of Pharmacology and Experimental Therapeutics. 329 (2): 429–38. doi:10.1124/jpet.108.143362. PMID 19182070.
  14. ↑ Doggrell SA (Jun 2003). "Does the melanin-concentrating hormone antagonist SNAP-7941 deserve 3As?". Expert Opinion on Investigational Drugs. 12 (6): 1035–8. doi:10.1517/13543784.12.6.1035. PMID 12783607.
  15. ↑ David DJ, Klemenhagen KC, Holick KA, Saxe MD, Mendez I, Santarelli L, Craig DA, Zhong H, Swanson CJ, Hegde LG, Ping XI, Dong D, Marzabadi MR, Gerald CP, Hen R (Apr 2007). "Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis". The Journal of Pharmacology and Experimental Therapeutics. 321 (1): 237–48. doi:10.1124/jpet.106.109678. PMID 17237257.
  16. ↑ Takekawa S, Asami A, Ishihara Y, Terauchi J, Kato K, Shimomura Y, Mori M, Murakoshi H, Kato K, Suzuki N, Nishimura O, Fujino M (Mar 2002). "T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist". European Journal of Pharmacology. 438 (3): 129–35. doi:10.1016/S0014-2999(02)01314-6. PMID 11909603.

Further reading

  • Kolakowski LF, Jung BP, Nguyen T, Johnson MP, Lynch KR, Cheng R, Heng HH, George SR, O'Dowd BF (Dec 1996). "Characterization of a human gene related to genes encoding somatostatin receptors". FEBS Letters. 398 (2–3): 253–8. doi:10.1016/S0014-5793(96)01160-X. PMID 8977118.
  • Chambers J, Ames RS, Bergsma D, Muir A, Fitzgerald LR, Hervieu G, Dytko GM, Foley JJ, Martin J, Liu WS, Park J, Ellis C, Ganguly S, Konchar S, Cluderay J, Leslie R, Wilson S, Sarau HM (Jul 1999). "Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1". Nature. 400 (6741): 261–5. doi:10.1038/22313. PMID 10421367.
  • Saito Y, Nothacker HP, Wang Z, Lin SH, Leslie F, Civelli O (Jul 1999). "Molecular characterization of the melanin-concentrating-hormone receptor". Nature. 400 (6741): 265–9. doi:10.1038/22321. PMID 10421368.
  • Shimomura Y, Mori M, Sugo T, Ishibashi Y, Abe M, Kurokawa T, Onda H, Nishimura O, Sumino Y, Fujino M (Aug 1999). "Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor". Biochemical and Biophysical Research Communications. 261 (3): 622–6. doi:10.1006/bbrc.1999.1104. PMID 10441476.
  • Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  • Macdonald D, Murgolo N, Zhang R, Durkin JP, Yao X, Strader CD, Graziano MP (Jul 2000). "Molecular characterization of the melanin-concentrating hormone/receptor complex: identification of critical residues involved in binding and activation". Molecular Pharmacology. 58 (1): 217–25. PMID 10860944.
  • An S, Cutler G, Zhao JJ, Huang SG, Tian H, Li W, Liang L, Rich M, Bakleh A, Du J, Chen JL, Dai K (Jun 2001). "Identification and characterization of a melanin-concentrating hormone receptor". Proceedings of the National Academy of Sciences of the United States of America. 98 (13): 7576–81. doi:10.1073/pnas.131200698. PMC 34710. PMID 11416225.
  • Bednarek MA, Feighner SD, Hreniuk DL, Palyha OC, Morin NR, Sadowski SJ, MacNeil DJ, Howard AD, Van der Ploeg LH (Aug 2001). "Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2". Biochemistry. 40 (31): 9379–86. doi:10.1021/bi010867p. PMID 11478907.
  • Bednarek MA, Tan C, Hreniuk DL, Palyha OC, MacNeil DJ, Van Der Ploeg LH, Howard AD, Feighner SD (Apr 2002). "Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1". The Journal of Biological Chemistry. 277 (16): 13821–6. doi:10.1074/jbc.M200563200. PMID 11839762.
  • Audinot V, Lahaye C, Suply T, Rovère-Jovène C, Rodriguez M, Nicolas JP, Beauverger P, Cardinaud B, Galizzi JP, Fauchère JL, Nahon JL, Boutin JA (Jul 2002). "SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor". Biochemical and Biophysical Research Communications. 295 (4): 841–8. doi:10.1016/S0006-291X(02)00763-5. PMID 12127971.
  • Hoogduijn MJ, Ancans J, Suzuki I, Estdale S, Thody AJ (Aug 2002). "Melanin-concentrating hormone and its receptor are expressed and functional in human skin". Biochemical and Biophysical Research Communications. 296 (3): 698–701. doi:10.1016/S0006-291X(02)00932-4. PMID 12176038.
  • Bächner D, Kreienkamp HJ, Richter D (Aug 2002). "MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein". FEBS Letters. 526 (1–3): 124–8. doi:10.1016/S0014-5793(02)03115-0. PMID 12208518.
  • Verlaet M, Adamantidis A, Coumans B, Chanas G, Zorzi W, Heinen E, Grisar T, Lakaye B (Sep 2002). "Human immune cells express ppMCH mRNA and functional MCHR1 receptor". FEBS Letters. 527 (1–3): 205–10. doi:10.1016/S0014-5793(02)03232-5. PMID 12220661.
  • Logan DW, Bryson-Richardson RJ, Pagán KE, Taylor MS, Currie PD, Jackson IJ (Feb 2003). "The structure and evolution of the melanocortin and MCH receptors in fish and mammals". Genomics. 81 (2): 184–91. doi:10.1016/S0888-7543(02)00037-X. PMID 12620396.
  • Pissios P, Trombly DJ, Tzameli I, Maratos-Flier E (Aug 2003). "Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways". Endocrinology. 144 (8): 3514–23. doi:10.1210/en.2002-0004. PMID 12865333.
  • Gottumukkala RV, Waterman EA, Herd LM, Gawkrodger DJ, Watson PF, Weetman AP, Kemp EH (Oct 2003). "Autoantibodies in vitiligo patients recognize multiple domains of the melanin-concentrating hormone receptor". The Journal of Investigative Dermatology. 121 (4): 765–70. doi:10.1046/j.1523-1747.2003.12494.x. PMID 14632194.
  • Gibson WT, Pissios P, Trombly DJ, Luan J, Keogh J, Wareham NJ, Maratos-Flier E, O'Rahilly S, Farooqi IS (May 2004). "Melanin-concentrating hormone receptor mutations and human obesity: functional analysis". Obesity Research. 12 (5): 743–9. doi:10.1038/oby.2004.89. PMID 15166293.
  • Hawes BE, Green B, O'Neill K, Fried S, Arreaza MG, Qiu P, Simon JS (Aug 2004). "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2". Obesity Research. 12 (8): 1327–34. doi:10.1038/oby.2004.167. PMID 15340116.
  • Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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