Tachykinin receptor: Difference between revisions
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==Binding== | ==Binding== | ||
The genes and receptor ligands are as follows:<ref name="pmid7557266">{{cite journal | | The genes and receptor ligands are as follows:<ref name="pmid7557266">{{cite journal | vauthors = Maggi CA | title = The mammalian tachykinin receptors | journal = General Pharmacology | volume = 26 | issue = 5 | pages = 911–44 | date = September 1995 | pmid = 7557266 | doi = 10.1016/0306-3623(94)00292-U }}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
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([[Tomas Hökfelt|Hökfelt]] et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000) | ([[Tomas Hökfelt|Hökfelt]] et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000) | ||
==See also== | == See also == | ||
*[[Substance P]] | *[[Substance P]] | ||
*[[G protein coupled receptor]]s | *[[G protein coupled receptor]]s | ||
==References== | == References == | ||
{{reflist}} | |||
==External links== | == External links == | ||
*{{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1354 | title = Tachykinin Receptors | | * {{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1354 | title = Tachykinin Receptors | access-date = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology }} | ||
* {{MeshName|Tachykinin+Receptor}} | * {{MeshName|Tachykinin+Receptor}} | ||
| Line 89: | Line 89: | ||
{{Neurokinin receptor modulators}} | {{Neurokinin receptor modulators}} | ||
[[Category:G protein coupled receptors]] | [[Category:G protein-coupled receptors]] | ||
[[Category:Molecular neuroscience]] | [[Category:Molecular neuroscience]] | ||
{{biochem-stub}} | {{biochem-stub}} | ||
Latest revision as of 11:54, 10 January 2019
| tachykinin receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | TACR1 |
| Alt. symbols | TAC1R |
| Entrez | 6869 |
| HUGO | 11526 |
| OMIM | 162323 |
| RefSeq | NM_001058 |
| UniProt | P25103 |
| Other data | |
| Locus | Chr. 2 p13.1-p12 |
| tachykinin receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | TACR2 |
| Alt. symbols | TAC2R, NKNAR |
| Entrez | 6865 |
| HUGO | 11527 |
| OMIM | 162321 |
| RefSeq | NM_001057 |
| UniProt | P21452 |
| Other data | |
| Locus | Chr. 10 q11-q21 |
| tachykinin receptor 3 | |
|---|---|
| Identifiers | |
| Symbol | TACR3 |
| Entrez | 6870 |
| HUGO | 11528 |
| OMIM | 162332 |
| RefSeq | NM_001059 |
| UniProt | P29371 |
| Other data | |
| Locus | Chr. 4 q25 |
There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled).
Binding
The genes and receptor ligands are as follows:[1]
| Receptor | Gene | Preferred ligand |
| NK1 | TACR1 | substance P |
| NK2 | TACR2 | neurokinin A |
| NK3 | TACR3 | neurokinin B |
(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)
See also
References
- ↑ Maggi CA (September 1995). "The mammalian tachykinin receptors". General Pharmacology. 26 (5): 911–44. doi:10.1016/0306-3623(94)00292-U. PMID 7557266.
External links
- "Tachykinin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Tachykinin+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
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