Neuropeptide Y receptor Y1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Neuropeptide Y receptor type 1''' is a [[protein]] that in humans is encoded by the ''NPY1R'' [[gene]].<ref name="pmid8095935">{{cite journal | vauthors = Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J | title = Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor | journal = The Journal of Biological Chemistry | volume = 268 | issue = 9 | pages = 6703–7 | date = March 1993 | pmid = 8095935 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NPY1R neuropeptide Y receptor Y1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4886| access-date = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Selective ligands ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Neuropeptide Y receptor Y1
| HGNCid = 7956
| Symbol = NPY1R
| AltSymbols =; NPYR
| OMIM = 162641
| ECnumber = 
| Homologene = 700
| MGIid = 104963
| GeneAtlas_image1 = PBB_GE_NPY1R_205440_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0001601 |text = peptide YY receptor activity}} {{GNF_GO|id=GO:0001602 |text = pancreatic polypeptide receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004983 |text = neuropeptide Y receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006006 |text = glucose metabolic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007193 |text = G-protein signaling, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0019233 |text = sensory perception of pain}} {{GNF_GO|id=GO:0040014 |text = regulation of body size}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4886
    | Hs_Ensembl = ENSG00000164128
    | Hs_RefseqProtein = NP_000900
    | Hs_RefseqmRNA = NM_000909
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 164464567
    | Hs_GenLoc_end = 164473198
    | Hs_Uniprot = P25929
    | Mm_EntrezGene = 18166
    | Mm_Ensembl = ENSMUSG00000036437
    | Mm_RefseqmRNA = NM_010934
    | Mm_RefseqProtein = NP_035064
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 69632837
    | Mm_GenLoc_end = 69635097
    | Mm_Uniprot = Q3V1K5
  }}
}}
'''Neuropeptide Y receptor Y1''', also known as '''NPY1R''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NPY1R neuropeptide Y receptor Y1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4886| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
=== Agonists ===
{{PBB_Summary
* [[Neuropeptide Y]] (endogenous agonist, non subtype selective)
| section_title =  
* [[Peptide YY]]
| summary_text =
}}


==See also==
=== Antagonists ===
;Peptide
* BVD-10 (selective NPY<sub>1</sub> antagonist, CAS# 262418-00-8)
* GR-231,118 (mixed NPY<sub>1</sub> antagonist / NPY<sub>4</sub> agonist, CAS# 158859-98-4)
 
;Non-peptide
* BIBO-3304 (CAS# 191868-14-1)
* [[BIBP-3226]] (CAS# 159013-54-4)
* PD-160,170 (CAS# 181468-88-2)
 
== Available Structures ==
 
* [http://www.rcsb.org/structure/5ZBH 5ZBH] (Neuropeptide Y1 bound to antagonist BMS-193835)<ref name=":0">{{cite journal | vauthors = Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B | title = 1 receptor | language = En | journal = Nature | volume = 556 | issue = 7702 | pages = 520–524 | date = April 2018 | pmid = 29670288 | pmc = 5920736 | doi = 10.1038/s41586-018-0046-x | url = http://www.nature.com/articles/s41586-018-0046-x }}</ref>
* [http://www.rcsb.org/structure/5ZBQ 5ZBQ] (Neuropeptide Y1 bound to antagonist UR-MK299)<ref name=":0" />
 
== See also ==
* [[Neuropeptide Y receptor]]
* [[Neuropeptide Y receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|33em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wan CP, Lau BH | title = Neuropeptide Y receptor subtypes | journal = Life Sciences | volume = 56 | issue = 13 | pages = 1055–64 | date = February 1995 | pmid = 9001438 | doi = 10.1016/0024-3205(95)00041-4 }}
| citations =
* {{cite journal | vauthors = Parker E, Van Heek M, Stamford A | title = Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status | journal = European Journal of Pharmacology | volume = 440 | issue = 2-3 | pages = 173–87 | date = April 2002 | pmid = 12007534 | doi = 10.1016/S0014-2999(02)01427-9 }}
*{{cite journal | author=Wan CP, Lau BH |title=Neuropeptide Y receptor subtypes. |journal=Life Sci. |volume=56 |issue= 13 |pages= 1055-64 |year= 1997 |pmid= 9001438 |doi= }}
* {{cite journal | vauthors = Bettio A, Beck-Sickinger AG | title = Biophysical methods to study ligand-receptor interactions of neuropeptide Y | journal = Biopolymers | volume = 60 | issue = 6 | pages = 420–37 | year = 2002 | pmid = 12209475 | doi = 10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W }}
*{{cite journal | author=Parker E, Van Heek M, Stamford A |title=Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status. |journal=Eur. J. Pharmacol. |volume=440 |issue= 2-3 |pages= 173-87 |year= 2002 |pmid= 12007534 |doi= }}
* {{cite journal | vauthors = Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlested C | title = Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type | journal = The Journal of Biological Chemistry | volume = 267 | issue = 16 | pages = 10935–8 | date = June 1992 | pmid = 1317848 | doi =  }}
*{{cite journal | author=Bettio A, Beck-Sickinger AG |title=Biophysical methods to study ligand-receptor interactions of neuropeptide Y. |journal=Biopolymers |volume=60 |issue= 6 |pages= 420-37 |year= 2002 |pmid= 12209475 |doi= 10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W }}
* {{cite journal | vauthors = Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA | title = Cloned human neuropeptide Y receptor couples to two different second messenger systems | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 13 | pages = 5794–8 | date = July 1992 | pmid = 1321422 | pmc = 402104 | doi = 10.1073/pnas.89.13.5794 }}
*{{cite journal | author=Larhammar D, Blomqvist AG, Yee F, ''et al.'' |title=Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. |journal=J. Biol. Chem. |volume=267 |issue= 16 |pages= 10935-8 |year= 1992 |pmid= 1317848 |doi=  }}
* {{cite journal | vauthors = Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R | title = Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor | journal = The Journal of Biological Chemistry | volume = 270 | issue = 39 | pages = 22661–4 | date = September 1995 | pmid = 7559383 | doi = 10.1074/jbc.270.39.22661 }}
*{{cite journal | author=Herzog H, Hort YJ, Ball HJ, ''et al.'' |title=Cloned human neuropeptide Y receptor couples to two different second messenger systems. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 13 |pages= 5794-8 |year= 1992 |pmid= 1321422 |doi= }}
* {{cite journal | vauthors = Gicquiaux H, Lecat S, Gaire M, Dieterlen A, Mély Y, Takeda K, Bucher B, Galzi JL | title = Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 8 | pages = 6645–55 | date = February 2002 | pmid = 11741903 | doi = 10.1074/jbc.M107224200 }}
*{{cite journal | author=Rose PM, Fernandes P, Lynch JS, ''et al.'' |title=Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. |journal=J. Biol. Chem. |volume=270 |issue= 39 |pages= 22661-4 |year= 1995 |pmid= 7559383 |doi= }}
* {{cite journal | vauthors = Sheriff S, F  Qureshy A, T  Chance W, Kasckow JW, Balasubramaniam A | title = Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected] | journal = Peptides | volume = 23 | issue = 1 | pages = 87–96 | date = January 2002 | pmid = 11814622 | doi = 10.1016/S0196-9781(01)00583-6 }}
*{{cite journal  | author=Herzog H, Baumgartner M, Vivero C, ''et al.'' |title=Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor. |journal=J. Biol. Chem. |volume=268 |issue= 9 |pages= 6703-7 |year= 1993 |pmid= 8095935 |doi=  }}
* {{cite journal | vauthors = Cox HM, Tough IR | title = Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa | journal = British Journal of Pharmacology | volume = 135 | issue = 6 | pages = 1505–12 | date = March 2002 | pmid = 11906964 | pmc = 1573267 | doi = 10.1038/sj.bjp.0704604 }}
*{{cite journal | author=Gicquiaux H, Lecat S, Gaire M, ''et al.'' |title=Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6645-55 |year= 2002 |pmid= 11741903 |doi= 10.1074/jbc.M107224200 }}
* {{cite journal | vauthors = Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L | title = Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues | journal = Peptides | volume = 23 | issue = 5 | pages = 927–34 | date = May 2002 | pmid = 12084524 | doi = 10.1016/S0196-9781(02)00003-7 }}
*{{cite journal | author=Sheriff S, F  Qureshy A, T  Chance W, ''et al.'' |title=Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]. |journal=Peptides |volume=23 |issue= 1 |pages= 87-96 |year= 2002 |pmid= 11814622 |doi= }}
* {{cite journal | vauthors = Cantó Soler MV, Gallo JE, Dodds RA, Hökfelt T, Villar MJ, Suburo AM | title = Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina | journal = Glia | volume = 39 | issue = 3 | pages = 320–4 | date = September 2002 | pmid = 12203398 | doi = 10.1002/glia.10107 }}
*{{cite journal | author=Cox HM, Tough IR |title=Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa. |journal=Br. J. Pharmacol. |volume=135 |issue= 6 |pages= 1505-12 |year= 2002 |pmid= 11906964 |doi= 10.1038/sj.bjp.0704604 }}
* {{cite journal | vauthors = Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR | title = The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 306 | issue = 1 | pages = 147–56 | date = July 2003 | pmid = 12665544 | doi = 10.1124/jpet.103.051227 }}
*{{cite journal | author=Uddman R, Möller S, Nilsson T, ''et al.'' |title=Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues. |journal=Peptides |volume=23 |issue= 5 |pages= 927-34 |year= 2003 |pmid= 12084524 |doi= }}
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = July 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
*{{cite journal | author=Cantó Soler MV, Gallo JE, Dodds RA, ''et al.'' |title=Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina. |journal=Glia |volume=39 |issue= 3 |pages= 320-4 |year= 2002 |pmid= 12203398 |doi= 10.1002/glia.10107 }}
* {{cite journal | vauthors = Körner M, Waser B, Reubi JC | title = High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia | journal = Clinical Cancer Research | volume = 10 | issue = 24 | pages = 8426–33 | date = December 2004 | pmid = 15623622 | doi = 10.1158/1078-0432.CCR-04-0821 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Berglund MM, Schober DA, Statnick MA, ''et al.'' |title=The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction. |journal=J. Pharmacol. Exp. Ther. |volume=306 |issue= 1 |pages= 147-56 |year= 2003 |pmid= 12665544 |doi= 10.1124/jpet.103.051227 }}
*{{cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Körner M, Waser B, Reubi JC |title=High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia. |journal=Clin. Cancer Res. |volume=10 |issue= 24 |pages= 8426-33 |year= 2005 |pmid= 15623622 |doi= 10.1158/1078-0432.CCR-04-0821 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
== External links ==
{{G protein-coupled receptors}}
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2366 | title = Neuropeptide Y Receptors: Y<sub>1</sub> | access-date = | author = | authorlink = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archive-url = | archive-date = | quote = }}
[[Category:G protein coupled receptors]]
 
{{WikiDoc Sources}}
{{transmembranereceptor-stub}}
{{G protein-coupled receptors|g1}}
{{Neuropeptidergics}}
 
[[Category:G protein-coupled receptors]]

Latest revision as of 12:02, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.[1][2]

Selective ligands

Agonists

Antagonists

Peptide
  • BVD-10 (selective NPY1 antagonist, CAS# 262418-00-8)
  • GR-231,118 (mixed NPY1 antagonist / NPY4 agonist, CAS# 158859-98-4)
Non-peptide
  • BIBO-3304 (CAS# 191868-14-1)
  • BIBP-3226 (CAS# 159013-54-4)
  • PD-160,170 (CAS# 181468-88-2)

Available Structures

  • 5ZBH (Neuropeptide Y1 bound to antagonist BMS-193835)[3]
  • 5ZBQ (Neuropeptide Y1 bound to antagonist UR-MK299)[3]

See also

References

  1. ↑ Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (March 1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor". The Journal of Biological Chemistry. 268 (9): 6703–7. PMID 8095935.
  2. ↑ "Entrez Gene: NPY1R neuropeptide Y receptor Y1".
  3. ↑ 3.0 3.1 Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B (April 2018). "1 receptor". Nature. 556 (7702): 520–524. doi:10.1038/s41586-018-0046-x. PMC 5920736. PMID 29670288.

Further reading

External links

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