Relaxin/insulin-like family peptide receptor 1: Difference between revisions
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'''Relaxin/insulin-like family peptide receptor 1''', also known as '''RXFP1''', is a human [[G protein coupled receptor]] that is one of the [[relaxin receptor]]s.<ref name="entrez">{{cite web | title = Entrez Gene: RXFP1 relaxin/insulin-like family peptide receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59350| accessdate = }}</ref> | |||
}} | |||
'''Relaxin/insulin-like family peptide receptor 1''', also known as '''RXFP1''', is a human [[ | |||
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==See also== | ==See also== | ||
* [[Relaxin | * [[Relaxin family peptide hormones]] | ||
* [[Insulin/IGF/Relaxin family]] | |||
* [[Relaxin]] | |||
** [[Relaxin-3]] | |||
==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3022 | title = Relaxin Family Peptide Receptors: RXFP1 | accessdate = | date = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = }} | |||
==Further reading== | ==Further reading== | ||
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{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | *{{cite journal |vauthors=Bathgate RA, Ivell R, Sanborn BM, etal |title=Receptors for relaxin family peptides |journal=Ann. N. Y. Acad. Sci. |volume=1041 |issue= |pages= 61–76 |year= 2005 |pmid= 15956688 |doi= 10.1196/annals.1282.010 }} | ||
*{{cite journal | *{{cite journal |vauthors=Bathgate RA, Ivell R, Sanborn BM, etal |title=International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides |journal=Pharmacol. Rev. |volume=58 |issue= 1 |pages= 7–31 |year= 2006 |pmid= 16507880 |doi= 10.1124/pr.58.1.9 }} | ||
*{{cite journal | *{{cite journal |vauthors=Hsu SY, Kudo M, Chen T, etal |title=The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7 |journal=Mol. Endocrinol. |volume=14 |issue= 8 |pages= 1257–71 |year= 2001 |pmid= 10935549 |doi=10.1210/me.14.8.1257 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Bartsch O, Bartlick B, Ivell R |title=Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity |journal=Mol. Hum. Reprod. |volume=7 |issue= 9 |pages= 799–809 |year= 2001 |pmid= 11517286 |doi=10.1093/molehr/7.9.799 }} | ||
*{{cite journal | *{{cite journal |vauthors=Hsu SY, Nakabayashi K, Nishi S, etal |title=Activation of orphan receptors by the hormone relaxin |journal=Science |volume=295 |issue= 5555 |pages= 671–4 |year= 2002 |pmid= 11809971 |doi= 10.1126/science.1065654 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Sudo S, Kumagai J, Nishi S, etal |title=H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2 |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 7855–62 |year= 2003 |pmid= 12506116 |doi= 10.1074/jbc.M212457200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ivell R, Balvers M, Pohnke Y, etal |title=Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates |journal=Reprod. Biol. Endocrinol. |volume=1 |issue= |pages= 114 |year= 2004 |pmid= 14633277 |doi= 10.1186/1477-7827-1-114 | pmc=293425 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal | *{{cite journal |vauthors=Luna JJ, Riesewijk A, Horcajadas JA, etal |title=Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle |journal=Mol. Hum. Reprod. |volume=10 |issue= 2 |pages= 85–90 |year= 2004 |pmid= 14742692 |doi=10.1093/molehr/gah019 }} | ||
*{{cite journal | *{{cite journal |vauthors=Bond CP, Parry LJ, Samuel CS, etal |title=Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 7 |pages= 3477–85 |year= 2004 |pmid= 15240635 |doi= 10.1210/jc.2003-030798 }} | ||
*{{cite journal | *{{cite journal |vauthors=Liu C, Chen J, Kuei C, etal |title=Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7 |journal=Mol. Pharmacol. |volume=67 |issue= 1 |pages= 231–40 |year= 2005 |pmid= 15465925 |doi= 10.1124/mol.104.006700 }} | ||
*{{cite journal | *{{cite journal |vauthors=Scott DJ, Layfield S, Riesewijk A, etal |title=Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7 |journal=Clin. Exp. Pharmacol. Physiol. |volume=31 |issue= 11 |pages= 828–32 |year= 2005 |pmid= 15566402 |doi= 10.1111/j.1440-1681.2004.04075.x }} | ||
*{{cite journal | | *{{cite journal | vauthors=Büllesbach EE, Schwabe C |title=The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7 |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 14051–6 |year= 2005 |pmid= 15695505 |doi= 10.1074/jbc.M500030200 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Tang M, Mazella J, Zhu HH, Tseng L |title=Ligand activated relaxin receptor increases the transcription of IGFBP-1 and prolactin in human decidual and endometrial stromal cells |journal=Mol. Hum. Reprod. |volume=11 |issue= 4 |pages= 237–43 |year= 2005 |pmid= 15722441 |doi= 10.1093/molehr/gah149 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Hopkins EJ, Bathgate RA, Gooley PR |title=The human LGR7 low-density lipoprotein class A module requires calcium for structure |journal=Ann. N. Y. Acad. Sci. |volume=1041 |issue= |pages= 27–34 |year= 2005 |pmid= 15956684 |doi= 10.1196/annals.1282.006 }} | ||
*{{cite journal | *{{cite journal |vauthors=Bond CP, Parry LJ, Samuel CS, etal |title=Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle |journal=Ann. N. Y. Acad. Sci. |volume=1041 |issue= |pages= 136–43 |year= 2005 |pmid= 15956698 |doi= 10.1196/annals.1282.020 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Halls ML, Bathgate RA, Summers RJ |title=Signal switching after stimulation of LGR7 receptors by human relaxin 2 |journal=Ann. N. Y. Acad. Sci. |volume=1041 |issue= |pages= 288–91 |year= 2005 |pmid= 15956719 |doi= 10.1196/annals.1282.042 }} | ||
*{{cite journal | *{{cite journal |vauthors=Muda M, He C, Martini PG, etal |title=Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity |journal=Mol. Hum. Reprod. |volume=11 |issue= 8 |pages= 591–600 |year= 2005 |pmid= 16051677 |doi= 10.1093/molehr/gah205 }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=59350}} | |||
{{NLM content}} | {{NLM content}} | ||
{{G protein-coupled receptors}} | {{G protein-coupled receptors}} | ||
{{Protein and peptide receptor modulators}} | |||
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{{DEFAULTSORT:Relaxin insulin-like family peptide receptor 1}} | |||
[[Category:G protein-coupled receptors]] | |||
{{ | {{transmembranereceptor-stub}} |
Latest revision as of 12:03, 10 January 2019
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Species | Human | Mouse | |||||
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Location (UCSC) | n/a | n/a | |||||
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Relaxin/insulin-like family peptide receptor 1, also known as RXFP1, is a human G protein coupled receptor that is one of the relaxin receptors.[1]
See also
References
External links
- "Relaxin Family Peptide Receptors: RXFP1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Further reading
- Bathgate RA, Ivell R, Sanborn BM, et al. (2005). "Receptors for relaxin family peptides". Ann. N. Y. Acad. Sci. 1041: 61–76. doi:10.1196/annals.1282.010. PMID 15956688.
- Bathgate RA, Ivell R, Sanborn BM, et al. (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880.
- Hsu SY, Kudo M, Chen T, et al. (2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7". Mol. Endocrinol. 14 (8): 1257–71. doi:10.1210/me.14.8.1257. PMID 10935549.
- Bartsch O, Bartlick B, Ivell R (2001). "Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity". Mol. Hum. Reprod. 7 (9): 799–809. doi:10.1093/molehr/7.9.799. PMID 11517286.
- Hsu SY, Nakabayashi K, Nishi S, et al. (2002). "Activation of orphan receptors by the hormone relaxin". Science. 295 (5555): 671–4. doi:10.1126/science.1065654. PMID 11809971.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sudo S, Kumagai J, Nishi S, et al. (2003). "H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2". J. Biol. Chem. 278 (10): 7855–62. doi:10.1074/jbc.M212457200. PMID 12506116.
- Ivell R, Balvers M, Pohnke Y, et al. (2004). "Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates". Reprod. Biol. Endocrinol. 1: 114. doi:10.1186/1477-7827-1-114. PMC 293425. PMID 14633277.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Luna JJ, Riesewijk A, Horcajadas JA, et al. (2004). "Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle". Mol. Hum. Reprod. 10 (2): 85–90. doi:10.1093/molehr/gah019. PMID 14742692.
- Bond CP, Parry LJ, Samuel CS, et al. (2004). "Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle". J. Clin. Endocrinol. Metab. 89 (7): 3477–85. doi:10.1210/jc.2003-030798. PMID 15240635.
- Liu C, Chen J, Kuei C, et al. (2005). "Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7". Mol. Pharmacol. 67 (1): 231–40. doi:10.1124/mol.104.006700. PMID 15465925.
- Scott DJ, Layfield S, Riesewijk A, et al. (2005). "Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7". Clin. Exp. Pharmacol. Physiol. 31 (11): 828–32. doi:10.1111/j.1440-1681.2004.04075.x. PMID 15566402.
- Büllesbach EE, Schwabe C (2005). "The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7". J. Biol. Chem. 280 (14): 14051–6. doi:10.1074/jbc.M500030200. PMID 15695505.
- Tang M, Mazella J, Zhu HH, Tseng L (2005). "Ligand activated relaxin receptor increases the transcription of IGFBP-1 and prolactin in human decidual and endometrial stromal cells". Mol. Hum. Reprod. 11 (4): 237–43. doi:10.1093/molehr/gah149. PMID 15722441.
- Hopkins EJ, Bathgate RA, Gooley PR (2005). "The human LGR7 low-density lipoprotein class A module requires calcium for structure". Ann. N. Y. Acad. Sci. 1041: 27–34. doi:10.1196/annals.1282.006. PMID 15956684.
- Bond CP, Parry LJ, Samuel CS, et al. (2005). "Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle". Ann. N. Y. Acad. Sci. 1041: 136–43. doi:10.1196/annals.1282.020. PMID 15956698.
- Halls ML, Bathgate RA, Summers RJ (2005). "Signal switching after stimulation of LGR7 receptors by human relaxin 2". Ann. N. Y. Acad. Sci. 1041: 288–91. doi:10.1196/annals.1282.042. PMID 15956719.
- Muda M, He C, Martini PG, et al. (2005). "Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity". Mol. Hum. Reprod. 11 (8): 591–600. doi:10.1093/molehr/gah205. PMID 16051677.
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