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{{Infobox gene}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
'''G protein-coupled receptor family C group 6 member A''' ('''GPRC6A''') is a [[protein]] that in humans is encoded by the ''GPRC6A'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=222545| accessdate = }}</ref> This protein functions as a receptor of <small>L</small>-α-[[amino acid]]s,<ref name="pmid15576628">{{cite journal |vauthors=Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H | title = Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids | journal = Mol. Pharmacol. | volume = 67 | issue = 3 | pages = 589–97 | year = 2005 | pmid = 15576628 | doi = 10.1124/mol.104.007559 }}</ref> [[cation]]s (e.g., [[calcium]]),<ref name="pmid16199532">{{cite journal |vauthors=Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD | title = Identification of a novel extracellular cation-sensing G-protein-coupled receptor | journal = J. Biol. Chem. | volume = 280 | issue = 48 | pages = 40201–9 | date = December 2005 | pmid = 16199532 | pmc = 1435382 | doi = 10.1074/jbc.M505186200 | url =  }}</ref> [[osteocalcin]],<ref name="pmid21425331">{{cite journal |vauthors=Pi M, Wu Y, Quarles LD | title = GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo | journal = J. Bone Miner. Res. | volume = 26 | issue = 7 | pages = 1680–3 | date = July 2011 | pmid = 21425331 | doi = 10.1002/jbmr.390 | url =  | pmc = 5079536 }}</ref> and [[steroid]]s.<ref name="pmid20947496">{{cite journal |vauthors=Pi M, Parrill AL, Quarles LD | title = GPRC6A mediates the non-genomic effects of steroids | journal = J. Biol. Chem. | volume = 285 | issue = 51 | pages = 39953–64 | date = December 2010 | pmid = 20947496 | pmc = 3000977 | doi = 10.1074/jbc.M110.158063 | url = }}</ref> It is a [[membrane androgen receptor]].
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = G protein-coupled receptor, family C, group 6, member A
| HGNCid = 18510
| Symbol = GPRC6A
| AltSymbols =; GPCR; bA86F4.3
| OMIM = 
| ECnumber = 
| Homologene = 17529
| MGIid = 2429498
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}}
| Component = {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0019722 |text = calcium-mediated signaling}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 222545
    | Hs_Ensembl = ENSG00000173612
    | Hs_RefseqProtein = NP_683766
    | Hs_RefseqmRNA = NM_148963
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 117219941
    | Hs_GenLoc_end = 117256891
    | Hs_Uniprot = Q5T6X5
    | Mm_EntrezGene = 210198
    | Mm_Ensembl = ENSMUSG00000019905
    | Mm_RefseqmRNA = NM_153071
    | Mm_RefseqProtein = NP_694711
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 51303238
    | Mm_GenLoc_end = 51319873
    | Mm_Uniprot = Q8K4Z6
  }}
}}
'''G protein-coupled receptor, family C, group 6, member A''', also known as '''GPRC6A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=222545| accessdate = }}</ref> This receptor functions as a sensor of L-[[amino acid]]s.<ref name="pmid15576628">{{cite journal | author = Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H | title = Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids | journal = Mol. Pharmacol. | volume = 67 | issue = 3 | pages = 589–97 | year = 2005 | pmid = 15576628 | doi = 10.1124/mol.104.007559 | issn = }}</ref>


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==Clinical significance==
{{PBB_Summary
GPRC6A has also been linked to [[prostate cancer]] progression, and it has been shown to mediate rapid, non-genomic prostate cancer cell responses to [[testosterone]].<ref name="pmid21681779">{{cite journal |vauthors=Pi M, Quarles LD | title = GPRC6A regulates prostate cancer progression | journal = Prostate | volume = 72 | issue = 4 | pages = 399–409 | date = June 2011 | pmid = 21681779 | doi = 10.1002/pros.21442 | pmc=3183291}}</ref>
| section_title =  
 
| summary_text =  
==See also==
}}
* [[ZIP9]]


==References==
==References==
{{reflist|2}}
{{Reflist|2}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal |vauthors=Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M | title = Creation of genome-wide protein expression libraries using random activation of gene expression. | journal = Nat. Biotechnol. | volume = 19 | issue = 5 | pages = 440–5 | year = 2001 | pmid = 11329013 | doi = 10.1038/88107 }}
| citations =
*{{cite journal |vauthors=Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S | title = Identification of G protein-coupled receptor genes from the human genome sequence. | journal = FEBS Lett. | volume = 520 | issue = 1–3 | pages = 97–101 | year = 2002 | pmid = 12044878 | doi = 10.1016/S0014-5793(02)02775-8 }}
*{{cite journal | author=Harrington JJ, Sherf B, Rundlett S, ''et al.'' |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440-5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 }}
*{{cite journal |vauthors=Wellendorph P, Bräuner-Osborne H | title = Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor | journal = Gene | volume = 335 | issue =  | pages = 37–46 | year = 2004 | pmid = 15194188 | doi = 10.1016/j.gene.2004.03.003 }}
*{{cite journal | author=Takeda S, Kadowaki S, Haga T, ''et al.'' |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97-101 |year= 2002 |pmid= 12044878 |doi=  }}
*{{cite journal |vauthors=Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H | title = Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids | journal = Mol. Pharmacol. | volume = 67 | issue = 3 | pages = 589–97 | year = 2005 | pmid = 15576628 | doi = 10.1124/mol.104.007559 }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal |vauthors=Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD | title = Identification of a novel extracellular cation-sensing G-protein-coupled receptor | journal = J. Biol. Chem. | volume = 280 | issue = 48 | pages = 40201–9 | year = 2006 | pmid = 16199532 | pmc = 1435382 | doi = 10.1074/jbc.M505186200 }}
*{{cite journal | author=Wellendorph P, Bräuner-Osborne H |title=Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. |journal=Gene |volume=335 |issue=  |pages= 37-46 |year= 2004 |pmid= 15194188 |doi= 10.1016/j.gene.2004.03.003 }}
*{{cite journal | author=Wellendorph P, Hansen KB, Balsgaard A, ''et al.'' |title=Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. |journal=Mol. Pharmacol. |volume=67 |issue= 3 |pages= 589-97 |year= 2005 |pmid= 15576628 |doi= 10.1124/mol.104.007559 }}
*{{cite journal | author=Pi M, Faber P, Ekema G, ''et al.'' |title=Identification of a novel extracellular cation-sensing G-protein-coupled receptor. |journal=J. Biol. Chem. |volume=280 |issue= 48 |pages= 40201-9 |year= 2006 |pmid= 16199532 |doi= 10.1074/jbc.M505186200 }}
}}
{{refend}}
{{refend}}


==External links==
==External links==
*[http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2968 IUPHAR GPCR Database - GPRC<sub>6</sub>]
* {{MeshName|GPRC6A+protein,+human}}
* {{MeshName|GPRC6A+protein,+human}}
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2968 | title = Calcium-Sensing Receptors: GPRC<sub>6</sub>  | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
{{G protein-coupled receptors|g3}}
{{Androgen receptor modulators}}


{{G protein-coupled receptors}}
[[Category:G protein-coupled receptors]]
{{membrane-protein-stub}}
{{transmembranereceptor-stub}}
[[Category:G protein coupled receptors]]
{{WikiDoc Sources}}

Latest revision as of 19:23, 15 December 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

G protein-coupled receptor family C group 6 member A (GPRC6A) is a protein that in humans is encoded by the GPRC6A gene.[1] This protein functions as a receptor of L-α-amino acids,[2] cations (e.g., calcium),[3] osteocalcin,[4] and steroids.[5] It is a membrane androgen receptor.

Clinical significance

GPRC6A has also been linked to prostate cancer progression, and it has been shown to mediate rapid, non-genomic prostate cancer cell responses to testosterone.[6]

See also

References

  1. ↑ "Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A".
  2. ↑ Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628.
  3. ↑ Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD (December 2005). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor". J. Biol. Chem. 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMC 1435382. PMID 16199532.
  4. ↑ Pi M, Wu Y, Quarles LD (July 2011). "GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo". J. Bone Miner. Res. 26 (7): 1680–3. doi:10.1002/jbmr.390. PMC 5079536. PMID 21425331.
  5. ↑ Pi M, Parrill AL, Quarles LD (December 2010). "GPRC6A mediates the non-genomic effects of steroids". J. Biol. Chem. 285 (51): 39953–64. doi:10.1074/jbc.M110.158063. PMC 3000977. PMID 20947496.
  6. ↑ Pi M, Quarles LD (June 2011). "GPRC6A regulates prostate cancer progression". Prostate. 72 (4): 399–409. doi:10.1002/pros.21442. PMC 3183291. PMID 21681779.

Further reading

  • Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
  • Wellendorph P, Bräuner-Osborne H (2004). "Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor". Gene. 335: 37–46. doi:10.1016/j.gene.2004.03.003. PMID 15194188.
  • Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628.
  • Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD (2006). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor". J. Biol. Chem. 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMC 1435382. PMID 16199532.

External links

Retrieved from "https://www.wikidoc.org/index.php?title=GPRC6A&oldid=1533226"