CXCR6: Difference between revisions

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{{Infobox_gene}}
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'''C-X-C chemokine receptor type 6''' is a [[protein]] that in humans is encoded by the ''CXCR6'' [[gene]].<ref name="Liao_1997">{{cite journal | vauthors = Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM | title = STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1 | journal = The Journal of Experimental Medicine | volume = 185 | issue = 11 | pages = 2015–23 | date = June 1997 | pmid = 9166430 | pmc = 2196334 | doi = 10.1084/jem.185.11.2015 }}</ref><ref name="Deng_1997">{{cite journal | vauthors = Deng HK, Unutmaz D, KewalRamani VN, Littman DR | title = Expression cloning of new receptors used by simian and human immunodeficiency viruses | journal = Nature | volume = 388 | issue = 6639 | pages = 296–300 | date = July 1997 | pmid = 9230441 | pmc = | doi = 10.1038/40894 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CXCR6 chemokine (C-X-C motif) receptor 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10663| accessdate = }}</ref> CXCR6 has also recently been designated '''CD186''' ([[cluster of differentiation]] 186).
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CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.<ref name="Liao_1997"/><ref name="Deng_1997"/><ref name="entrez"/><ref name = "Elliott_2014"/> It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor.<ref name = "Elliott_2014">{{cite journal | vauthors = Elliott ST, Wetzel KS, Francella N, Bryan S, Romero DC, Riddick NE, Shaheen F, Vanderford T, Derdeyn CA, Silvestri G, Paiardini M, Collman RG | title = Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIV | journal = Journal of Virology | volume = 89 | issue = 18 | pages = 9252–61 | date = September 2015 | pmid = 26109719 | doi = 10.1128/JVI.01236-15 | pmc=4542357}}</ref> CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
  | Name = Chemokine (C-X-C motif) receptor 6
  | HGNCid = 16647
| Symbol = CXCR6
| AltSymbols =; BONZO; CD186; STRL33; TYMSTR
| OMIM = 605163
| ECnumber = 
| Homologene = 38197
| MGIid = 1934582
| GeneAtlas_image1 = PBB_GE_CXCR6_206974_at_tn.png
| GeneAtlas_image2 = PBB_GE_CXCR6_211469_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0015026 |text = coreceptor activity}} {{GNF_GO|id=GO:0016493 |text = C-C chemokine receptor activity}} {{GNF_GO|id=GO:0016494 |text = C-X-C chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0019079 |text = viral genome replication}}  
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10663
    | Hs_Ensembl = ENSG00000172215
    | Hs_RefseqProtein = NP_006555
    | Hs_RefseqmRNA = NM_006564
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 45957429
    | Hs_GenLoc_end = 45964833
    | Hs_Uniprot = O00574
    | Mm_EntrezGene = 80901
    | Mm_Ensembl = ENSMUSG00000048521
    | Mm_RefseqmRNA = NM_030712
    | Mm_RefseqProtein = NP_109637
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 123655197
    | Mm_GenLoc_end = 123660458
    | Mm_Uniprot = 
  }}
}}
'''Chemokine (C-X-C motif) receptor 6''', also known as '''CXCR6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CXCR6 chemokine (C-X-C motif) receptor 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10663| accessdate = }}</ref>


CXCR6 has also recently been designated '''CD186''' ([[cluster of differentiation]] 186).
== References ==
{{reflist}}


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== Further reading ==
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| summary_text =
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==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM | title = HIV-1 infection and chemokine receptor modulation | journal = Current HIV Research | volume = 2 | issue = 1 | pages = 39–50 | date = January 2004 | pmid = 15053339 | doi = 10.2174/1570162043484997 }}
| citations =
* {{cite journal | vauthors = Loetscher M, Amara A, Oberlin E, Brass N, Legler D, Loetscher P, D'Apuzzo M, Meese E, Rousset D, Virelizier JL, Baggiolini M, Arenzana-Seisdedos F, Moser B | title = TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function | journal = Current Biology | volume = 7 | issue = 9 | pages = 652–60 | date = September 1997 | pmid = 9285716 | doi = 10.1016/S0960-9822(06)00292-2 }}
*{{cite journal | author=Ruibal-Ares BH, Belmonte L, Baré PC, ''et al.'' |title=HIV-1 infection and chemokine receptor modulation. |journal=Curr. HIV Res. |volume=2 |issue= 1 |pages= 39-50 |year= 2004 |pmid= 15053339 |doi=  }}
* {{cite journal | vauthors = Hoffman TL, Stephens EB, Narayan O, Doms RW | title = HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 19 | pages = 11360–5 | date = September 1998 | pmid = 9736741 | pmc = 21647 | doi = 10.1073/pnas.95.19.11360 }}
*{{cite journal  | author=Liao F, Alkhatib G, Peden KW, ''et al.'' |title=STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. |journal=J. Exp. Med. |volume=185 |issue= 11 |pages= 2015-23 |year= 1997 |pmid= 9166430 |doi=  }}
* {{cite journal | vauthors = Schramm B, Penn ML, Speck RF, Chan SY, De Clercq E, Schols D, Connor RI, Goldsmith MA | title = Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease | journal = Journal of Virology | volume = 74 | issue = 1 | pages = 184–92 | date = January 2000 | pmid = 10590105 | pmc = 111527 | doi = 10.1128/JVI.74.1.184-192.2000 }}
*{{cite journal  | author=Deng HK, Unutmaz D, KewalRamani VN, Littman DR |title=Expression cloning of new receptors used by simian and human immunodeficiency viruses. |journal=Nature |volume=388 |issue= 6639 |pages= 296-300 |year= 1997 |pmid= 9230441 |doi= 10.1038/40894 }}
* {{cite journal | vauthors = Tscherning-Casper C, Vödrös D, Menu E, Aperia K, Fredriksson R, Dolcini G, Chaouat G, Barré-Sinoussi F, Albert J, Fenyö EM | title = Coreceptor usage of HIV-1 isolates representing different genetic subtypes obtained from pregnant Cameroonian women. European Network for In Utero Transmission of HIV-1 | journal = Journal of Acquired Immune Deficiency Syndromes | volume = 24 | issue = 1 | pages = 1–9 | date = May 2000 | pmid = 10877489 | doi = 10.1097/00126334-200005010-00001 }}
*{{cite journal | author=Loetscher M, Amara A, Oberlin E, ''et al.'' |title=TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function. |journal=Curr. Biol. |volume=7 |issue= 9 |pages= 652-60 |year= 1998 |pmid= 9285716 |doi= }}
* {{cite journal | vauthors = Ignatius R, Wei Y, Beaulieu S, Gettie A, Steinman RM, Pope M, Mojsov S | title = The immunodeficiency virus coreceptor, Bonzo/STRL33/TYMSTR, is expressed by macaque and human skin- and blood-derived dendritic cells | journal = AIDS Research and Human Retroviruses | volume = 16 | issue = 11 | pages = 1055–9 | date = July 2000 | pmid = 10933620 | doi = 10.1089/08892220050075318 }}
*{{cite journal | author=Hoffman TL, Stephens EB, Narayan O, Doms RW |title=HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11360-5 |year= 1998 |pmid= 9736741 |doi= }}
* {{cite journal | vauthors = Unutmaz D, Xiang W, Sunshine MJ, Campbell J, Butcher E, Littman DR | title = The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse | journal = Journal of Immunology | volume = 165 | issue = 6 | pages = 3284–92 | date = September 2000 | pmid = 10975845 | doi = 10.4049/jimmunol.165.6.3284 }}
*{{cite journal | author=Schramm B, Penn ML, Speck RF, ''et al.'' |title=Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease. |journal=J. Virol. |volume=74 |issue= 1 |pages= 184-92 |year= 2000 |pmid= 10590105 |doi= }}
* {{cite journal | vauthors = Matloubian M, David A, Engel S, Ryan JE, Cyster JG | title = A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo | journal = Nature Immunology | volume = 1 | issue = 4 | pages = 298–304 | date = October 2000 | pmid = 11017100 | doi = 10.1038/79738 }}
*{{cite journal | author=Tscherning-Casper C, Vödrös D, Menu E, ''et al.'' |title=Coreceptor usage of HIV-1 isolates representing different genetic subtypes obtained from pregnant Cameroonian women. European Network for In Utero Transmission of HIV-1. |journal=J. Acquir. Immune Defic. Syndr. |volume=24 |issue= 1 |pages= 1-9 |year= 2000 |pmid= 10877489 |doi= }}
* {{cite journal | vauthors = Wilbanks A, Zondlo SC, Murphy K, Mak S, Soler D, Langdon P, Andrew DP, Wu L, Briskin M | title = Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines | journal = Journal of Immunology | volume = 166 | issue = 8 | pages = 5145–54 | date = April 2001 | pmid = 11290797 | doi = 10.4049/jimmunol.166.8.5145 }}
*{{cite journal | author=Ignatius R, Wei Y, Beaulieu S, ''et al.'' |title=The immunodeficiency virus coreceptor, Bonzo/STRL33/TYMSTR, is expressed by macaque and human skin- and blood-derived dendritic cells. |journal=AIDS Res. Hum. Retroviruses |volume=16 |issue= 11 |pages= 1055-9 |year= 2000 |pmid= 10933620 |doi= 10.1089/08892220050075318 }}
* {{cite journal | vauthors = Lee B, Leslie G, Soilleux E, O'Doherty U, Baik S, Levroney E, Flummerfelt K, Swiggard W, Coleman N, Malim M, Doms RW | title = cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor | journal = Journal of Virology | volume = 75 | issue = 24 | pages = 12028–38 | date = December 2001 | pmid = 11711593 | pmc = 116098 | doi = 10.1128/JVI.75.24.12028-12038.2001 }}
*{{cite journal | author=Unutmaz D, Xiang W, Sunshine MJ, ''et al.'' |title=The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse. |journal=J. Immunol. |volume=165 |issue= 6 |pages= 3284-92 |year= 2000 |pmid= 10975845 |doi= }}
* {{cite journal | vauthors = Calabresi PA, Yun SH, Allie R, Whartenby KA | title = Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells | journal = Journal of Neuroimmunology | volume = 127 | issue = 1-2 | pages = 96–105 | date = June 2002 | pmid = 12044980 | doi = 10.1016/S0165-5728(02)00106-6 }}
*{{cite journal | author=Matloubian M, David A, Engel S, ''et al.'' |title=A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. |journal=Nat. Immunol. |volume=1 |issue= 4 |pages= 298-304 |year= 2001 |pmid= 11017100 |doi= 10.1038/79738 }}
* {{cite journal | vauthors = Kim CH, Johnston B, Butcher EC | title = Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity | journal = Blood | volume = 100 | issue = 1 | pages = 11–6 | date = July 2002 | pmid = 12070001 | doi = 10.1182/blood-2001-12-0196 }}
*{{cite journal | author=Wilbanks A, Zondlo SC, Murphy K, ''et al.'' |title=Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines. |journal=J. Immunol. |volume=166 |issue= 8 |pages= 5145-54 |year= 2001 |pmid= 11290797 |doi= }}
* {{cite journal | vauthors = Duggal P, An P, Beaty TH, Strathdee SA, Farzadegan H, Markham RB, Johnson L, O'Brien SJ, Vlahov D, Winkler CA | title = Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans | journal = Genes and Immunity | volume = 4 | issue = 4 | pages = 245–50 | date = June 2003 | pmid = 12761559 | doi = 10.1038/sj.gene.6363950 }}
*{{cite journal | author=Lee B, Leslie G, Soilleux E, ''et al.'' |title=cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor. |journal=J. Virol. |volume=75 |issue= 24 |pages= 12028-38 |year= 2001 |pmid= 11711593 |doi= 10.1128/JVI.75.24.12028-12038.2001 }}
* {{cite journal | vauthors = Koprak S, Matheravidathu S, Springer M, Gould S, Dumont FJ | title = Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin | journal = Cellular Immunology | volume = 223 | issue = 1 | pages = 1–12 | date = May 2003 | pmid = 12914753 | doi = 10.1016/S0008-8749(03)00130-8 }}
*{{cite journal | author=Calabresi PA, Yun SH, Allie R, Whartenby KA |title=Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells. |journal=J. Neuroimmunol. |volume=127 |issue= 1-2 |pages= 96-105 |year= 2002 |pmid= 12044980 |doi= }}
* {{cite journal | vauthors = Shimaoka T, Nakayama T, Fukumoto N, Kume N, Takahashi S, Yamaguchi J, Minami M, Hayashida K, Kita T, Ohsumi J, Yoshie O, Yonehara S | title = Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells | journal = Journal of Leukocyte Biology | volume = 75 | issue = 2 | pages = 267–74 | date = February 2004 | pmid = 14634054 | doi = 10.1189/jlb.1003465 }}
*{{cite journal | author=Kim CH, Johnston B, Butcher EC |title=Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity. |journal=Blood |volume=100 |issue= 1 |pages= 11-6 |year= 2002 |pmid= 12070001 |doi= 10.1182/blood-2001-12-0196 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Duggal P, An P, Beaty TH, ''et al.'' |title=Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans. |journal=Genes Immun. |volume=4 |issue= 4 |pages= 245-50 |year= 2004 |pmid= 12761559 |doi= 10.1038/sj.gene.6363950 }}
*{{cite journal | author=Koprak S, Matheravidathu S, Springer M, ''et al.'' |title=Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin. |journal=Cell. Immunol. |volume=223 |issue= 1 |pages= 1-12 |year= 2003 |pmid= 12914753 |doi= }}
*{{cite journal | author=Shimaoka T, Nakayama T, Fukumoto N, ''et al.'' |title=Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells. |journal=J. Leukoc. Biol. |volume=75 |issue= 2 |pages= 267-74 |year= 2004 |pmid= 14634054 |doi= 10.1189/jlb.1003465 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2873 | title = Chemokine Receptors: CXCR6 | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
* {{UCSC gene info|CXCR6}}


{{NLM content}}
{{NLM content}}
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{{Chemokine receptors}}
{{Chemokine receptors}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
{{Chemokine receptor modulators}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
[[Category:Chemokine receptors]]
[[Category:Chemokine receptors]]
{{WikiDoc Sources}}
 
 
{{transmembranereceptor-stub}}

Latest revision as of 10:12, 30 August 2017

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene.[1][2][3] CXCR6 has also recently been designated CD186 (cluster of differentiation 186).

CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.[1][2][3][4] It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor.[4] CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.

References

  1. ↑ 1.0 1.1 Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM (June 1997). "STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1". The Journal of Experimental Medicine. 185 (11): 2015–23. doi:10.1084/jem.185.11.2015. PMC 2196334. PMID 9166430.
  2. ↑ 2.0 2.1 Deng HK, Unutmaz D, KewalRamani VN, Littman DR (July 1997). "Expression cloning of new receptors used by simian and human immunodeficiency viruses". Nature. 388 (6639): 296–300. doi:10.1038/40894. PMID 9230441.
  3. ↑ 3.0 3.1 "Entrez Gene: CXCR6 chemokine (C-X-C motif) receptor 6".
  4. ↑ 4.0 4.1 Elliott ST, Wetzel KS, Francella N, Bryan S, Romero DC, Riddick NE, Shaheen F, Vanderford T, Derdeyn CA, Silvestri G, Paiardini M, Collman RG (September 2015). "Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIV". Journal of Virology. 89 (18): 9252–61. doi:10.1128/JVI.01236-15. PMC 4542357. PMID 26109719.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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