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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Galanin receptor 1''' ('''GAL<sub>1</sub>''') is a [[G-protein coupled receptor]] encoded by the '''GALR1''' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GALR1 galanin receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2587| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Galanin receptor 1
| HGNCid = 4132
| Symbol = GALR1
| AltSymbols =; GALNR; GALNR1
| OMIM = 600377
| ECnumber = 
| Homologene = 74396
| MGIid = 1096364
| GeneAtlas_image1 = PBB_GE_GALR1_220821_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004966 |text = galanin receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007194 |text = negative regulation of adenylate cyclase activity}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007586 |text = digestion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2587
    | Hs_Ensembl = ENSG00000166573
    | Hs_RefseqProtein = NP_001471
    | Hs_RefseqmRNA = NM_001480
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 73090721
    | Hs_GenLoc_end = 73111081
    | Hs_Uniprot = P47211
    | Mm_EntrezGene = 14427
    | Mm_Ensembl = ENSMUSG00000024553
    | Mm_RefseqmRNA = NM_008082
    | Mm_RefseqProtein = NP_032108
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 82527585
    | Mm_GenLoc_end = 82540899
    | Mm_Uniprot = P56479
  }}
}}
'''Galanin receptor 1''', also known as '''GALR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GALR1 galanin receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2587| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors.  Galanin receptors are seven-trans membrane proteins shown to activate a variety of intracellular second-messenger pathways.  GALR1 inhibits adenylyl cyclase via a G protein of the GI/GO family.  GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.<ref name="entrez">{{cite web | title = Entrez Gene: GALR1 galanin receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2587| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors.  Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways.  GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family.  GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.<ref name="entrez">{{cite web | title = Entrez Gene: GALR1 galanin receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2587| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Galanin receptor]]
* [[Galanin receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|33em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Habert-Ortoli E, Amiranoff B, Loquet I, Laburthe M, Mayaux JF | title = Molecular cloning of a functional human galanin receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 21 | pages = 9780–3 | date = Oct 1994 | pmid = 7524088 | pmc = 44900 | doi = 10.1073/pnas.91.21.9780 }}
| citations =
* {{cite journal | vauthors = Walli R, Schäfer H, Morys-Wortmann C, Paetzold G, Nustede R, Schmidt WE | title = Identification and biochemical characterization of the human brain galanin receptor | journal = Journal of Molecular Endocrinology | volume = 13 | issue = 3 | pages = 347–56 | date = Dec 1994 | pmid = 7534460 | doi = 10.1677/jme.0.0130347 }}
*{{cite journal | author=Habert-Ortoli E, Amiranoff B, Loquet I, ''et al.'' |title=Molecular cloning of a functional human galanin receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 21 |pages= 9780-3 |year= 1994 |pmid= 7524088 |doi= }}
* {{cite journal | vauthors = Kask K, Berthold M, Kahl U, Nordvall G, Bartfai T | title = Delineation of the peptide binding site of the human galanin receptor | journal = The EMBO Journal | volume = 15 | issue = 2 | pages = 236–44 | date = Jan 1996 | pmid = 8617199 | pmc = 449938 | doi =  }}
*{{cite journal | author=Walli R, Schäfer H, Morys-Wortmann C, ''et al.'' |title=Identification and biochemical characterization of the human brain galanin receptor. |journal=J. Mol. Endocrinol. |volume=13 |issue= 3 |pages= 347-56 |year= 1995 |pmid= 7534460 |doi= }}
* {{cite journal | vauthors = Lorimer DD, Benya RV | title = Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human gastrointestinal tract | journal = Biochemical and Biophysical Research Communications | volume = 222 | issue = 2 | pages = 379–85 | date = May 1996 | pmid = 8670213 | doi = 10.1006/bbrc.1996.0752 }}
*{{cite journal | author=Kask K, Berthold M, Kahl U, ''et al.'' |title=Delineation of the peptide binding site of the human galanin receptor. |journal=EMBO J. |volume=15 |issue= 2 |pages= 236-44 |year= 1996 |pmid= 8617199 |doi=  }}
* {{cite journal | vauthors = Nicholl J, Kofler B, Sutherland GR, Shine J, Iismaa TP | title = Assignment of the gene encoding human galanin receptor (GALNR) to 18q23 by in situ hybridization | journal = Genomics | volume = 30 | issue = 3 | pages = 629–30 | date = Dec 1995 | pmid = 8825658 | doi = 10.1006/geno.1995.1292 }}
*{{cite journal | author=Lorimer DD, Benya RV |title=Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human gastrointestinal tract. |journal=Biochem. Biophys. Res. Commun. |volume=222 |issue= 2 |pages= 379-85 |year= 1996 |pmid= 8670213 |doi= 10.1006/bbrc.1996.0752 }}
* {{cite journal | vauthors = Sullivan KA, Shiao LL, Cascieri MA | title = Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors | journal = Biochemical and Biophysical Research Communications | volume = 233 | issue = 3 | pages = 823–8 | date = Apr 1997 | pmid = 9168941 | doi = 10.1006/bbrc.1997.6542 }}
*{{cite journal | author=Nicholl J, Kofler B, Sutherland GR, ''et al.'' |title=Assignment of the gene encoding human galanin receptor (GALNR) to 18q23 by in situ hybridization. |journal=Genomics |volume=30 |issue= 3 |pages= 629-30 |year= 1997 |pmid= 8825658 |doi= 10.1006/geno.1995.1292 }}
* {{cite journal | vauthors = Jacoby AS, Webb GC, Liu ML, Kofler B, Hort YJ, Fathi Z, Bottema CD, Shine J, Iismaa TP | title = Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene | journal = Genomics | volume = 45 | issue = 3 | pages = 496–508 | date = Nov 1997 | pmid = 9367674 | doi = 10.1006/geno.1997.4960 }}
*{{cite journal | author=Sullivan KA, Shiao LL, Cascieri MA |title=Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors. |journal=Biochem. Biophys. Res. Commun. |volume=233 |issue= 3 |pages= 823-8 |year= 1997 |pmid= 9168941 |doi= 10.1006/bbrc.1997.6542 }}
* {{cite journal | vauthors = Lorimer DD, Matkowskj K, Benya RV | title = Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R) | journal = Biochemical and Biophysical Research Communications | volume = 241 | issue = 2 | pages = 558–64 | date = Dec 1997 | pmid = 9425310 | doi = 10.1006/bbrc.1997.7838 }}
*{{cite journal | author=Jacoby AS, Webb GC, Liu ML, ''et al.'' |title=Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene. |journal=Genomics |volume=45 |issue= 3 |pages= 496-508 |year= 1998 |pmid= 9367674 |doi= 10.1006/geno.1997.4960 }}
* {{cite journal | vauthors = Fitzgerald LW, Patterson JP, Conklin DS, Horlick R, Largent BL | title = Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 287 | issue = 2 | pages = 448–56 | date = Nov 1998 | pmid = 9808667 | doi =  }}
*{{cite journal | author=Lorimer DD, Matkowskj K, Benya RV |title=Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R). |journal=Biochem. Biophys. Res. Commun. |volume=241 |issue= 2 |pages= 558-64 |year= 1998 |pmid= 9425310 |doi= 10.1006/bbrc.1997.7838 }}
* {{cite journal | vauthors = Henson BS, Neubig RR, Jang I, Ogawa T, Zhang Z, Carey TE, D'Silva NJ | title = Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma | journal = The Journal of Biological Chemistry | volume = 280 | issue = 24 | pages = 22564–71 | date = Jun 2005 | pmid = 15767248 | doi = 10.1074/jbc.M414589200 }}
*{{cite journal | author=Fitzgerald LW, Patterson JP, Conklin DS, ''et al.'' |title=Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides. |journal=J. Pharmacol. Exp. Ther. |volume=287 |issue= 2 |pages= 448-56 |year= 1998 |pmid= 9808667 |doi=  }}
* {{cite journal | vauthors = Schäuble N, Reichwald K, Grassl W, Bechstein H, Müller HC, Scherag A, Geller F, Utting M, Siegfried W, Goldschmidt H, Blundell J, Lawton C, Alam R, Whybrow S, Stubbs J, Platzer M, Hebebrand J, Hinney A | title = Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity | journal = The Journal of Nutrition | volume = 135 | issue = 6 | pages = 1387–92 | date = Jun 2005 | pmid = 15930442 | doi =  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Belfer I, Hipp H, Bollettino A, McKnight C, Evans C, Virkkunen M, Albaugh B, Max MB, Goldman D, Enoch MA | title = Alcoholism is associated with GALR3 but not two other galanin receptor genes | journal = Genes, Brain, and Behavior | volume = 6 | issue = 5 | pages = 473–81 | date = Jul 2007 | pmid = 17083333 | doi = 10.1111/j.1601-183X.2006.00275.x }}
*{{cite journal  | author=Henson BS, Neubig RR, Jang I, ''et al.'' |title=Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma. |journal=J. Biol. Chem. |volume=280 |issue= 24 |pages= 22564-71 |year= 2005 |pmid= 15767248 |doi= 10.1074/jbc.M414589200 }}
*{{cite journal | author=Schäuble N, Reichwald K, Grassl W, ''et al.'' |title=Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity. |journal=J. Nutr. |volume=135 |issue= 6 |pages= 1387-92 |year= 2005 |pmid= 15930442 |doi=  }}
*{{cite journal | author=Belfer I, Hipp H, Bollettino A, ''et al.'' |title=Alcoholism is associated with GALR3 but not two other galanin receptor genes. |journal=Genes Brain Behav. |volume=6 |issue= 5 |pages= 473-81 |year= 2007 |pmid= 17083333 |doi= 10.1111/j.1601-183X.2006.00275.x }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2981 | title = Galanin Receptors: GAL<sub>1</sub> | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
 
{{transmembranereceptor-stub}}
{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors|g1}}
[[Category:G protein coupled receptors]]
{{Neuropeptidergics}}
{{WikiDoc Sources}}
 
[[Category:G protein-coupled receptors]]
[[sr:Galaninski receptor 3]]

Latest revision as of 09:02, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Galanin receptor 1 (GAL1) is a G-protein coupled receptor encoded by the GALR1 gene.[1]

Function

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-trans membrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the GI/GO family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: GALR1 galanin receptor 1".

Further reading

  • Habert-Ortoli E, Amiranoff B, Loquet I, Laburthe M, Mayaux JF (Oct 1994). "Molecular cloning of a functional human galanin receptor". Proceedings of the National Academy of Sciences of the United States of America. 91 (21): 9780–3. doi:10.1073/pnas.91.21.9780. PMC 44900. PMID 7524088.
  • Walli R, Schäfer H, Morys-Wortmann C, Paetzold G, Nustede R, Schmidt WE (Dec 1994). "Identification and biochemical characterization of the human brain galanin receptor". Journal of Molecular Endocrinology. 13 (3): 347–56. doi:10.1677/jme.0.0130347. PMID 7534460.
  • Kask K, Berthold M, Kahl U, Nordvall G, Bartfai T (Jan 1996). "Delineation of the peptide binding site of the human galanin receptor". The EMBO Journal. 15 (2): 236–44. PMC 449938. PMID 8617199.
  • Lorimer DD, Benya RV (May 1996). "Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human gastrointestinal tract". Biochemical and Biophysical Research Communications. 222 (2): 379–85. doi:10.1006/bbrc.1996.0752. PMID 8670213.
  • Nicholl J, Kofler B, Sutherland GR, Shine J, Iismaa TP (Dec 1995). "Assignment of the gene encoding human galanin receptor (GALNR) to 18q23 by in situ hybridization". Genomics. 30 (3): 629–30. doi:10.1006/geno.1995.1292. PMID 8825658.
  • Sullivan KA, Shiao LL, Cascieri MA (Apr 1997). "Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors". Biochemical and Biophysical Research Communications. 233 (3): 823–8. doi:10.1006/bbrc.1997.6542. PMID 9168941.
  • Jacoby AS, Webb GC, Liu ML, Kofler B, Hort YJ, Fathi Z, Bottema CD, Shine J, Iismaa TP (Nov 1997). "Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene". Genomics. 45 (3): 496–508. doi:10.1006/geno.1997.4960. PMID 9367674.
  • Lorimer DD, Matkowskj K, Benya RV (Dec 1997). "Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R)". Biochemical and Biophysical Research Communications. 241 (2): 558–64. doi:10.1006/bbrc.1997.7838. PMID 9425310.
  • Fitzgerald LW, Patterson JP, Conklin DS, Horlick R, Largent BL (Nov 1998). "Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides". The Journal of Pharmacology and Experimental Therapeutics. 287 (2): 448–56. PMID 9808667.
  • Henson BS, Neubig RR, Jang I, Ogawa T, Zhang Z, Carey TE, D'Silva NJ (Jun 2005). "Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma". The Journal of Biological Chemistry. 280 (24): 22564–71. doi:10.1074/jbc.M414589200. PMID 15767248.
  • Schäuble N, Reichwald K, Grassl W, Bechstein H, Müller HC, Scherag A, Geller F, Utting M, Siegfried W, Goldschmidt H, Blundell J, Lawton C, Alam R, Whybrow S, Stubbs J, Platzer M, Hebebrand J, Hinney A (Jun 2005). "Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity". The Journal of Nutrition. 135 (6): 1387–92. PMID 15930442.
  • Belfer I, Hipp H, Bollettino A, McKnight C, Evans C, Virkkunen M, Albaugh B, Max MB, Goldman D, Enoch MA (Jul 2007). "Alcoholism is associated with GALR3 but not two other galanin receptor genes". Genes, Brain, and Behavior. 6 (5): 473–81. doi:10.1111/j.1601-183X.2006.00275.x. PMID 17083333.

External links

  • "Galanin Receptors: GAL1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

sr:Galaninski receptor 3

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