Galanin receptor 3: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Galanin receptor 3''' ('''GAL<sub>3</sub>''') is a [[G-protein coupled receptor]] encoded by the '''GALR3''' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GALR3 galanin receptor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8484| accessdate = }}</ref>
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Galanin receptor 3
| HGNCid = 4134
| Symbol = GALR3
| AltSymbols =;
| OMIM = 603692
| ECnumber = 
| Homologene = 20798
| MGIid = 1329003
| GeneAtlas_image1 = PBB_GE_GALR3_33579_i_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004966 |text = galanin receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007194 |text = negative regulation of adenylate cyclase activity}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007611 |text = learning and/or memory}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8484
    | Hs_Ensembl = ENSG00000128310
    | Hs_RefseqProtein = NP_003605
    | Hs_RefseqmRNA = NM_003614
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 36549335
    | Hs_GenLoc_end = 36551448
    | Hs_Uniprot = O60755
    | Mm_EntrezGene = 14429
    | Mm_Ensembl = ENSMUSG00000047429
    | Mm_RefseqmRNA = XM_001001042
    | Mm_RefseqProtein = XP_001001042
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 78869187
    | Mm_GenLoc_end = 78870728
    | Mm_Uniprot = O88853
  }}
}}
'''Galanin receptor 3''', also known as '''GALR3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GALR3 galanin receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8484| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior.  The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways.  GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior.  The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways.  GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts<ref name="entrez">{{cite web | title = Entrez Gene: GALR3 galanin receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8484| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Galanin receptor]]
* [[Galanin receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|33em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Smith KE, Walker MW, Artymyshyn R, Bard J, Borowsky B, Tamm JA, Yao WJ, Vaysse PJ, Branchek TA, Gerald C, Jones KA | title = Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels | journal = The Journal of Biological Chemistry | volume = 273 | issue = 36 | pages = 23321–6 | date = Sep 1998 | pmid = 9722565 | doi = 10.1074/jbc.273.36.23321 }}
| citations =
* {{cite journal | vauthors = Kolakowski LF, O'Neill GP, Howard AD, Broussard SR, Sullivan KA, Feighner SD, Sawzdargo M, Nguyen T, Kargman S, Shiao LL, Hreniuk DL, Tan CP, Evans J, Abramovitz M, Chateauneuf A, Coulombe N, Ng G, Johnson MP, Tharian A, Khoshbouei H, George SR, Smith RG, O'Dowd BF | title = Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3 | journal = Journal of Neurochemistry | volume = 71 | issue = 6 | pages = 2239–51 | date = Dec 1998 | pmid = 9832121 | doi = 10.1046/j.1471-4159.1998.71062239.x }}
*{{cite journal | author=Smith KE, Walker MW, Artymyshyn R, ''et al.'' |title=Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23321-6 |year= 1998 |pmid= 9722565 |doi= }}
* {{cite journal | vauthors = Iismaa TP, Fathi Z, Hort YJ, Iben LG, Dutton JL, Baker E, Sutherland GR, Shine J | title = Structural organization and chromosomal localization of three human galanin receptor genes | journal = Annals of the New York Academy of Sciences | volume = 863 | issue =  | pages = 56–63 | date = Dec 1998 | pmid = 9928159 | doi = 10.1111/j.1749-6632.1998.tb10683.x }}
*{{cite journal | author=Kolakowski LF, O'Neill GP, Howard AD, ''et al.'' |title=Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3. |journal=J. Neurochem. |volume=71 |issue= 6 |pages= 2239-51 |year= 1998 |pmid= 9832121 |doi= }}
* {{cite journal | vauthors = Lapsys NM, Furler SM, Henderson NK, Dutton JL, Hort YJ, Eisman JA, Shine J, Iismaa TP | title = A polymorphism in the human GALR3 galanin receptor gene (GALNR3) | journal = Molecular and Cellular Probes | volume = 13 | issue = 4 | pages = 325–7 | date = Aug 1999 | pmid = 10441207 | doi = 10.1006/mcpr.1999.0254 }}
*{{cite journal | author=Iismaa TP, Fathi Z, Hort YJ, ''et al.'' |title=Structural organization and chromosomal localization of three human galanin receptor genes. |journal=Ann. N. Y. Acad. Sci. |volume=863 |issue=  |pages= 56-63 |year= 1999 |pmid= 9928159 |doi= }}
* {{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | date = Dec 1999 | pmid = 10591208 | doi = 10.1038/990031 }}
*{{cite journal | author=Lapsys NM, Furler SM, Henderson NK, ''et al.'' |title=A polymorphism in the human GALR3 galanin receptor gene (GALNR3). |journal=Mol. Cell. Probes |volume=13 |issue= 4 |pages= 325-7 |year= 1999 |pmid= 10441207 |doi= 10.1006/mcpr.1999.0254 }}
* {{cite journal | vauthors = Berger A, Tuechler C, Almer D, Kogner P, Ratschek M, Kerbl R, Iismaa TP, Jones N, Sperl W, Kofler B | title = Elevated expression of galanin receptors in childhood neuroblastic tumors | journal = Neuroendocrinology | volume = 75 | issue = 2 | pages = 130–8 | date = Feb 2002 | pmid = 11867941 | doi = 10.1159/000048229 }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
* {{cite journal | vauthors = Belfer I, Hipp H, Bollettino A, McKnight C, Evans C, Virkkunen M, Albaugh B, Max MB, Goldman D, Enoch MA | title = Alcoholism is associated with GALR3 but not two other galanin receptor genes | journal = Genes, Brain, and Behavior | volume = 6 | issue = 5 | pages = 473–81 | date = Jul 2007 | pmid = 17083333 | doi = 10.1111/j.1601-183X.2006.00275.x }}
*{{cite journal | author=Berger A, Tuechler C, Almer D, ''et al.'' |title=Elevated expression of galanin receptors in childhood neuroblastic tumors. |journal=Neuroendocrinology |volume=75 |issue= 2 |pages= 130-8 |year= 2002 |pmid= 11867941 |doi= }}
* {{cite journal | vauthors = Runesson J, Sollenberg UE, Jurkowski W, Yazdi S, Eriksson EE, Elofsson A, Langel U | title = Determining receptor-ligand interaction of human galanin receptor type 3 | journal = Neurochemistry International | volume = 57 | issue = 7 | pages = 804–11 | date = Dec 2010 | pmid = 20817064 | doi = 10.1016/j.neuint.2010.08.018 }}
*{{cite journal | author=Belfer I, Hipp H, Bollettino A, ''et al.'' |title=Alcoholism is associated with GALR3 but not two other galanin receptor genes. |journal=Genes Brain Behav. |volume=6 |issue= 5 |pages= 473-81 |year= 2007 |pmid= 17083333 |doi= 10.1111/j.1601-183X.2006.00275.x }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2983 | title = Galanin Receptors: GAL<sub>3</sub> | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
 
{{transmembranereceptor-stub}}
{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors|g1}}
[[Category:G protein coupled receptors]]
{{Neuropeptidergics}}
{{WikiDoc Sources}}
 
[[Category:G protein-coupled receptors]]

Latest revision as of 12:25, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Galanin receptor 3 (GAL3) is a G-protein coupled receptor encoded by the GALR3 gene.[1]

Function

The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: GALR3 galanin receptor 3".

Further reading

  • Smith KE, Walker MW, Artymyshyn R, Bard J, Borowsky B, Tamm JA, Yao WJ, Vaysse PJ, Branchek TA, Gerald C, Jones KA (Sep 1998). "Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels". The Journal of Biological Chemistry. 273 (36): 23321–6. doi:10.1074/jbc.273.36.23321. PMID 9722565.
  • Kolakowski LF, O'Neill GP, Howard AD, Broussard SR, Sullivan KA, Feighner SD, Sawzdargo M, Nguyen T, Kargman S, Shiao LL, Hreniuk DL, Tan CP, Evans J, Abramovitz M, Chateauneuf A, Coulombe N, Ng G, Johnson MP, Tharian A, Khoshbouei H, George SR, Smith RG, O'Dowd BF (Dec 1998). "Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3". Journal of Neurochemistry. 71 (6): 2239–51. doi:10.1046/j.1471-4159.1998.71062239.x. PMID 9832121.
  • Iismaa TP, Fathi Z, Hort YJ, Iben LG, Dutton JL, Baker E, Sutherland GR, Shine J (Dec 1998). "Structural organization and chromosomal localization of three human galanin receptor genes". Annals of the New York Academy of Sciences. 863: 56–63. doi:10.1111/j.1749-6632.1998.tb10683.x. PMID 9928159.
  • Lapsys NM, Furler SM, Henderson NK, Dutton JL, Hort YJ, Eisman JA, Shine J, Iismaa TP (Aug 1999). "A polymorphism in the human GALR3 galanin receptor gene (GALNR3)". Molecular and Cellular Probes. 13 (4): 325–7. doi:10.1006/mcpr.1999.0254. PMID 10441207.
  • Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  • Berger A, Tuechler C, Almer D, Kogner P, Ratschek M, Kerbl R, Iismaa TP, Jones N, Sperl W, Kofler B (Feb 2002). "Elevated expression of galanin receptors in childhood neuroblastic tumors". Neuroendocrinology. 75 (2): 130–8. doi:10.1159/000048229. PMID 11867941.
  • Belfer I, Hipp H, Bollettino A, McKnight C, Evans C, Virkkunen M, Albaugh B, Max MB, Goldman D, Enoch MA (Jul 2007). "Alcoholism is associated with GALR3 but not two other galanin receptor genes". Genes, Brain, and Behavior. 6 (5): 473–81. doi:10.1111/j.1601-183X.2006.00275.x. PMID 17083333.
  • Runesson J, Sollenberg UE, Jurkowski W, Yazdi S, Eriksson EE, Elofsson A, Langel U (Dec 2010). "Determining receptor-ligand interaction of human galanin receptor type 3". Neurochemistry International. 57 (7): 804–11. doi:10.1016/j.neuint.2010.08.018. PMID 20817064.

External links

  • "Galanin Receptors: GAL3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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