Hypocretin (orexin) receptor 1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Orexin receptor type 1''' ('''Ox1R''' or '''OX<sub>1</sub>'''), also known as  '''hypocretin receptor type 1''' ('''HcrtR1'''), is a [[protein]] that in humans is encoded by the '''HCRTR1''' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HCRTR1 hypocretin (orexin) receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3061| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Hypocretin (orexin) receptor 1
| HGNCid = 4848
| Symbol = HCRTR1
| AltSymbols =; OX1R
| OMIM = 602392
| ECnumber = 
| Homologene = 37492
| MGIid = 2385650
| GeneAtlas_image1 = PBB_GE_HCRTR1_207619_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0016499 |text = orexin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3061
    | Hs_Ensembl = ENSG00000121764
    | Hs_RefseqProtein = NP_001516
    | Hs_RefseqmRNA = NM_001525
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 31857228
    | Hs_GenLoc_end = 31870706
    | Hs_Uniprot = O43613
    | Mm_EntrezGene = 230777
    | Mm_Ensembl = ENSMUSG00000028778
    | Mm_RefseqmRNA = XM_983697
    | Mm_RefseqProtein = XP_988791
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 129633145
    | Mm_GenLoc_end = 129639932
    | Mm_Uniprot = Q0VDP5
  }}
}}
'''Hypocretin (orexin) receptor 1''', also known as '''HCRTR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HCRTR1 hypocretin (orexin) receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3061| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The orexin 1 receptor (OX<sub>1</sub>), is a [[G-protein coupled receptor]] that is heavily expressed in projections from the [[lateral hypothalamus]] and is involved in the regulation of feeding behaviour.  OX<sub>1</sub> selectively binds the [[orexin-A]] neuropeptide.  It shares 64% identity with [[Hypocretin (orexin) receptor 2|OX<sub>2</sub>]].<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = HCRTR1, or orexin 1 receptor (OX1R), is a G-protein coupled receptor expressed in the hypothalamus and involved in the regulation of feeding behaviour.  HCRTR1 selectively binds the orexin A neuropeptide.  It shares 64% identity with HCRTR2.<ref name="entrez">{{cite web | title = Entrez Gene: HCRTR1 hypocretin (orexin) receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3061| accessdate = }}</ref>
}}


==See also==
==Ligands==
 
===Agonists===
* [[Orexin-A]]
 
===Antagonists===
{{Further|Orexin antagonist}}
* [[RTIOX-276]] - Selective OX<sub>1</sub> antagonist
* [[ACT-335827]] - Selective OX<sub>1</sub> antagonist
* [[Almorexant]] - Dual OX<sub>1</sub> and [[Hypocretin (orexin) receptor 2|OX<sub>2</sub>]] [[receptor antagonist|antagonist]]
* [[Lemborexant]] - Dual OX<sub>1</sub> and [[Hypocretin (orexin) receptor 2|OX<sub>2</sub>]] [[receptor antagonist|antagonist]]<ref>{{cite web|url=http://www.marketwatch.com/story/eisai-demonstrates-efficacy-of-investigational-dual-orexin-receptor-antagonist-e2006-in-sleep-initiation-and-maintenance-data-from-phase-ii-clinical-trial-for-insomnia-2014-12-10}}</ref>
* [[Nemorexant]] - Dual OX<sub>1</sub> and OX<sub>2</sub> antagonist
* [[SB-334,867]] - Selective OX<sub>1</sub> antagonist
* [[SB-408,124]] - Selective OX<sub>1</sub> antagonist
* [[SB-649,868]] - Dual OX<sub>1</sub> and [[Hypocretin (orexin) receptor 2|OX<sub>2</sub>]] [[receptor antagonist|antagonist]]
* [[Suvorexant]] - Dual OX<sub>1</sub> and [[Hypocretin (orexin) receptor 2|OX<sub>2</sub>]] [[receptor antagonist|antagonist]]
 
== See also ==
* [[Orexin receptor]]
* [[Orexin receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}
 
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3012 | title = Orexin Receptors: OX<sub>1</sub> | accessdate = | author = | authorlink = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Flier JS, Maratos-Flier E | title = Obesity and the hypothalamus: novel peptides for new pathways | journal = Cell | volume = 92 | issue = 4 | pages = 437–40 | date = Feb 1998 | pmid = 9491885 | doi = 10.1016/S0092-8674(00)80937-X }}
| citations =
* {{cite journal | vauthors = Willie JT, Chemelli RM, Sinton CM, Yanagisawa M | title = To eat or to sleep? Orexin in the regulation of feeding and wakefulness | journal = Annual Review of Neuroscience | volume = 24 | issue =  | pages = 429–58 | year = 2001 | pmid = 11283317 | doi = 10.1146/annurev.neuro.24.1.429 }}
*{{cite journal | author=Flier JS, Maratos-Flier E |title=Obesity and the hypothalamus: novel peptides for new pathways. |journal=Cell |volume=92 |issue= 4 |pages= 437-40 |year= 1998 |pmid= 9491885 |doi= }}
* {{cite journal | vauthors = Hungs M, Mignot E | title = Hypocretin/orexin, sleep and narcolepsy | journal = BioEssays | volume = 23 | issue = 5 | pages = 397–408 | date = May 2001 | pmid = 11340621 | doi = 10.1002/bies.1058 }}
*{{cite journal | author=Willie JT, Chemelli RM, Sinton CM, Yanagisawa M |title=To eat or to sleep? Orexin in the regulation of feeding and wakefulness. |journal=Annu. Rev. Neurosci. |volume=24 |issue=  |pages= 429-58 |year= 2001 |pmid= 11283317 |doi= 10.1146/annurev.neuro.24.1.429 }}
* {{cite journal | vauthors = de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG | title = The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 1 | pages = 322–7 | date = Jan 1998 | pmid = 9419374 | pmc = 18213 | doi = 10.1073/pnas.95.1.322 }}
*{{cite journal | author=Hungs M, Mignot E |title=Hypocretin/orexin, sleep and narcolepsy. |journal=Bioessays |volume=23 |issue= 5 |pages= 397-408 |year= 2001 |pmid= 11340621 |doi= 10.1002/bies.1058 }}
* {{cite journal | vauthors = Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M | title = Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior | journal = Cell | volume = 92 | issue = 4 | pages = 573–85 | date = Feb 1998 | pmid = 9491897 | doi = 10.1016/S0092-8674(00)80949-6 | url = http://www.gghjournal.com/pdf/volume_14/14-3/14_3_leptin_ab2.pdf | format = PDF }}
*{{cite journal | author=de Lecea L, Kilduff TS, Peyron C, ''et al.'' |title=The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 1 |pages= 322-7 |year= 1998 |pmid= 9419374 |doi= }}
* {{cite journal | vauthors = Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M | title = Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior | journal = Cell | volume = 92 | issue = 5 | pages = 1 page following 696 | date = Mar 1998 | pmid = 9527442 | doi = 10.1016/S0092-8674(02)09256-5 }}
*{{cite journal | author=Sakurai T, Amemiya A, Ishii M, ''et al.'' |title=Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. |journal=Cell |volume=92 |issue= 4 |pages= 573-85 |year= 1998 |pmid= 9491897 |doi= }}
* {{cite journal | vauthors = Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E | title = A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains | journal = Nature Medicine | volume = 6 | issue = 9 | pages = 991–7 | date = Sep 2000 | pmid = 10973318 | doi = 10.1038/79690 }}
*{{cite journal | author=Sakurai T, Amemiya A, Ishii M, ''et al.'' |title=Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. |journal=Cell |volume=92 |issue= 5 |pages= 1 page following 696 |year= 1998 |pmid= 9527442 |doi= }}
* {{cite journal | vauthors = Blanco M, López M, GarcIa-Caballero T, Gallego R, Morel G, SeñarIs R, Casanueva F, Diéguez C, Beiras A | title = Cellular localization of orexin receptors in human pituitary | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 86 | issue = 7 | pages = 1616–9 | date = Jul 2001 | pmid = 11443222 | doi = 10.1210/jc.86.7.3444 }}
*{{cite journal | author=Peyron C, Faraco J, Rogers W, ''et al.'' |title=A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. |journal=Nat. Med. |volume=6 |issue= 9 |pages= 991-7 |year= 2000 |pmid= 10973318 |doi= 10.1038/79690 }}
* {{cite journal | vauthors = Olafsdóttir BR, Rye DB, Scammell TE, Matheson JK, Stefánsson K, Gulcher JR | title = Polymorphisms in hypocretin/orexin pathway genes and narcolepsy | journal = Neurology | volume = 57 | issue = 10 | pages = 1896–9 | date = Nov 2001 | pmid = 11723285 | doi = 10.1212/wnl.57.10.1896 }}
*{{cite journal | author=Blanco M, López M, GarcIa-Caballero T, ''et al.'' |title=Cellular localization of orexin receptors in human pituitary. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 7 |pages= 1616-9 |year= 2001 |pmid= 11443222 |doi= }}
* {{cite journal | vauthors = Wieland HA, Söll RM, Doods HN, Stenkamp D, Hurnaus R, Lämmle B, Beck-Sickinger AG | title = The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor | journal = European Journal of Biochemistry / FEBS | volume = 269 | issue = 4 | pages = 1128–35 | date = Feb 2002 | pmid = 11856342 | doi = 10.1046/j.0014-2956.2001.02739.x }}
*{{cite journal | author=Olafsdóttir BR, Rye DB, Scammell TE, ''et al.'' |title=Polymorphisms in hypocretin/orexin pathway genes and narcolepsy. |journal=Neurology |volume=57 |issue= 10 |pages= 1896-9 |year= 2002 |pmid= 11723285 |doi= }}
* {{cite journal | vauthors = Hilairet S, Bouaboula M, Carrière D, Le Fur G, Casellas P | title = Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 26 | pages = 23731–7 | date = Jun 2003 | pmid = 12690115 | doi = 10.1074/jbc.M212369200 }}
*{{cite journal | author=Wieland HA, Söll RM, Doods HN, ''et al.'' |title=The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor. |journal=Eur. J. Biochem. |volume=269 |issue= 4 |pages= 1128-35 |year= 2002 |pmid= 11856342 |doi= }}
* {{cite journal | vauthors = Karteris E, Chen J, Randeva HS | title = Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 89 | issue = 4 | pages = 1957–62 | date = Apr 2004 | pmid = 15070969 | doi = 10.1210/jc.2003-031778 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Holmqvist T, Johansson L, Ostman M, Ammoun S, Akerman KE, Kukkonen JP | title = OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms | journal = The Journal of Biological Chemistry | volume = 280 | issue = 8 | pages = 6570–9 | date = Feb 2005 | pmid = 15611118 | doi = 10.1074/jbc.M407397200 }}
*{{cite journal | author=Hilairet S, Bouaboula M, Carrière D, ''et al.'' |title=Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716. |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 23731-7 |year= 2003 |pmid= 12690115 |doi= 10.1074/jbc.M212369200 }}
* {{cite journal | vauthors = Spinazzi R, Rucinski M, Neri G, Malendowicz LK, Nussdorfer GG | title = Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 90 | issue = 6 | pages = 3544–9 | date = Jun 2005 | pmid = 15797953 | doi = 10.1210/jc.2004-2385 }}
*{{cite journal | author=Karteris E, Chen J, Randeva HS |title=Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 4 |pages= 1957-62 |year= 2004 |pmid= 15070969 |doi= }}
* {{cite journal | vauthors = Meerabux J, Iwayama Y, Sakurai T, Ohba H, Toyota T, Yamada K, Nagata R, Irukayama-Tomobe Y, Shimizu H, Yoshitsugu K, Ohta K, Yoshikawa T | title = Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects | journal = Biological Psychiatry | volume = 58 | issue = 5 | pages = 401–7 | date = Sep 2005 | pmid = 15978554 | doi = 10.1016/j.biopsych.2005.04.015 }}
*{{cite journal | author=Holmqvist T, Johansson L, Ostman M, ''et al.'' |title=OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms. |journal=J. Biol. Chem. |volume=280 |issue= 8 |pages= 6570-9 |year= 2005 |pmid= 15611118 |doi= 10.1074/jbc.M407397200 }}
* {{cite journal | vauthors = Ziolkowska A, Spinazzi R, Albertin G, Nowak M, Malendowicz LK, Tortorella C, Nussdorfer GG | title = Orexins stimulate glucocorticoid secretion from cultured rat and human adrenocortical cells, exclusively acting via the OX1 receptor | journal = The Journal of Steroid Biochemistry and Molecular Biology | volume = 96 | issue = 5 | pages = 423–9 | date = Sep 2005 | pmid = 16157481 | doi = 10.1016/j.jsbmb.2005.05.003 }}
*{{cite journal | author=Spinazzi R, Rucinski M, Neri G, ''et al.'' |title=Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 6 |pages= 3544-9 |year= 2005 |pmid= 15797953 |doi= 10.1210/jc.2004-2385 }}
*{{cite journal | author=Meerabux J, Iwayama Y, Sakurai T, ''et al.'' |title=Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. |journal=Biol. Psychiatry |volume=58 |issue= 5 |pages= 401-7 |year= 2005 |pmid= 15978554 |doi= 10.1016/j.biopsych.2005.04.015 }}
*{{cite journal | author=Ziolkowska A, Spinazzi R, Albertin G, ''et al.'' |title=Orexins stimulate glucocorticoid secretion from cultured rat and human adrenocortical cells, exclusively acting via the OX1 receptor. |journal=J. Steroid Biochem. Mol. Biol. |volume=96 |issue= 5 |pages= 423-9 |year= 2006 |pmid= 16157481 |doi= 10.1016/j.jsbmb.2005.05.003 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
{{Neuropeptidergics}}
{{WikiDoc Sources}}
 
 
[[Category:G protein-coupled receptors]]
{{transmembranereceptor-stub}}

Latest revision as of 18:01, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

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n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene.[1]

Function

The orexin 1 receptor (OX1), is a G-protein coupled receptor that is heavily expressed in projections from the lateral hypothalamus and is involved in the regulation of feeding behaviour. OX1 selectively binds the orexin-A neuropeptide. It shares 64% identity with OX2.[1]

Ligands

Agonists

Antagonists

Further information: Orexin antagonist

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: HCRTR1 hypocretin (orexin) receptor 1".
  2. ↑ http://www.marketwatch.com/story/eisai-demonstrates-efficacy-of-investigational-dual-orexin-receptor-antagonist-e2006-in-sleep-initiation-and-maintenance-data-from-phase-ii-clinical-trial-for-insomnia-2014-12-10. Missing or empty |title= (help)

External links

  • "Orexin Receptors: OX1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

  • Flier JS, Maratos-Flier E (Feb 1998). "Obesity and the hypothalamus: novel peptides for new pathways". Cell. 92 (4): 437–40. doi:10.1016/S0092-8674(00)80937-X. PMID 9491885.
  • Willie JT, Chemelli RM, Sinton CM, Yanagisawa M (2001). "To eat or to sleep? Orexin in the regulation of feeding and wakefulness". Annual Review of Neuroscience. 24: 429–58. doi:10.1146/annurev.neuro.24.1.429. PMID 11283317.
  • Hungs M, Mignot E (May 2001). "Hypocretin/orexin, sleep and narcolepsy". BioEssays. 23 (5): 397–408. doi:10.1002/bies.1058. PMID 11340621.
  • de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG (Jan 1998). "The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity". Proceedings of the National Academy of Sciences of the United States of America. 95 (1): 322–7. doi:10.1073/pnas.95.1.322. PMC 18213. PMID 9419374.
  • Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (Feb 1998). "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior" (PDF). Cell. 92 (4): 573–85. doi:10.1016/S0092-8674(00)80949-6. PMID 9491897.
  • Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (Mar 1998). "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior". Cell. 92 (5): 1 page following 696. doi:10.1016/S0092-8674(02)09256-5. PMID 9527442.
  • Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E (Sep 2000). "A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains". Nature Medicine. 6 (9): 991–7. doi:10.1038/79690. PMID 10973318.
  • Blanco M, López M, GarcIa-Caballero T, Gallego R, Morel G, SeñarIs R, Casanueva F, Diéguez C, Beiras A (Jul 2001). "Cellular localization of orexin receptors in human pituitary". The Journal of Clinical Endocrinology and Metabolism. 86 (7): 1616–9. doi:10.1210/jc.86.7.3444. PMID 11443222.
  • Olafsdóttir BR, Rye DB, Scammell TE, Matheson JK, Stefánsson K, Gulcher JR (Nov 2001). "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy". Neurology. 57 (10): 1896–9. doi:10.1212/wnl.57.10.1896. PMID 11723285.
  • Wieland HA, Söll RM, Doods HN, Stenkamp D, Hurnaus R, Lämmle B, Beck-Sickinger AG (Feb 2002). "The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor". European Journal of Biochemistry / FEBS. 269 (4): 1128–35. doi:10.1046/j.0014-2956.2001.02739.x. PMID 11856342.
  • Hilairet S, Bouaboula M, Carrière D, Le Fur G, Casellas P (Jun 2003). "Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716". The Journal of Biological Chemistry. 278 (26): 23731–7. doi:10.1074/jbc.M212369200. PMID 12690115.
  • Karteris E, Chen J, Randeva HS (Apr 2004). "Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system". The Journal of Clinical Endocrinology and Metabolism. 89 (4): 1957–62. doi:10.1210/jc.2003-031778. PMID 15070969.
  • Holmqvist T, Johansson L, Ostman M, Ammoun S, Akerman KE, Kukkonen JP (Feb 2005). "OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms". The Journal of Biological Chemistry. 280 (8): 6570–9. doi:10.1074/jbc.M407397200. PMID 15611118.
  • Spinazzi R, Rucinski M, Neri G, Malendowicz LK, Nussdorfer GG (Jun 2005). "Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells". The Journal of Clinical Endocrinology and Metabolism. 90 (6): 3544–9. doi:10.1210/jc.2004-2385. PMID 15797953.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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