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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Neuropeptide Y receptor type 1''' is a [[protein]] that in humans is encoded by the ''NPY1R'' [[gene]].<ref name="pmid8095935">{{cite journal | vauthors = Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J | title = Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor | journal = The Journal of Biological Chemistry | volume = 268 | issue = 9 | pages = 6703–7 | date = Mar 1993 | pmid = 8095935 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NPY1R neuropeptide Y receptor Y1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4886| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Selective ligands ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Neuropeptide Y receptor Y1
| HGNCid = 7956
| Symbol = NPY1R
| AltSymbols =; NPYR
| OMIM = 162641
| ECnumber = 
| Homologene = 700
| MGIid = 104963
| GeneAtlas_image1 = PBB_GE_NPY1R_205440_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0001601 |text = peptide YY receptor activity}} {{GNF_GO|id=GO:0001602 |text = pancreatic polypeptide receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004983 |text = neuropeptide Y receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006006 |text = glucose metabolic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007193 |text = G-protein signaling, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0019233 |text = sensory perception of pain}} {{GNF_GO|id=GO:0040014 |text = regulation of body size}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4886
    | Hs_Ensembl = ENSG00000164128
    | Hs_RefseqProtein = NP_000900
    | Hs_RefseqmRNA = NM_000909
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 164464567
    | Hs_GenLoc_end = 164473198
    | Hs_Uniprot = P25929
    | Mm_EntrezGene = 18166
    | Mm_Ensembl = ENSMUSG00000036437
    | Mm_RefseqmRNA = NM_010934
    | Mm_RefseqProtein = NP_035064
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 69632837
    | Mm_GenLoc_end = 69635097
    | Mm_Uniprot = Q3V1K5
  }}
}}
'''Neuropeptide Y receptor Y1''', also known as '''NPY1R''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NPY1R neuropeptide Y receptor Y1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4886| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
=== Agonists ===
{{PBB_Summary
* [[Neuropeptide Y]] (endogenous agonist, non subtype selective)
| section_title =  
* [[Peptide YY]]
| summary_text =
}}


==See also==
=== Antagonists ===
;Peptide
* BVD-10 (selective NPY<sub>1</sub> antagonist, CAS# 262418-00-8)
* GR-231,118 (mixed NPY<sub>1</sub> antagonist / NPY<sub>4</sub> agonist, CAS# 158859-98-4)
 
;Non-peptide
* BIBO-3304 (CAS# 191868-14-1)
* [[BIBP-3226]] (CAS# 159013-54-4)
* PD-160,170 (CAS# 181468-88-2)
 
== See also ==
* [[Neuropeptide Y receptor]]
* [[Neuropeptide Y receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|33em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wan CP, Lau BH | title = Neuropeptide Y receptor subtypes | journal = Life Sciences | volume = 56 | issue = 13 | pages = 1055–64 | date = Feb 1995 | pmid = 9001438 | doi = 10.1016/0024-3205(95)00041-4 }}
| citations =
* {{cite journal | vauthors = Parker E, Van Heek M, Stamford A | title = Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status | journal = European Journal of Pharmacology | volume = 440 | issue = 2-3 | pages = 173–87 | date = Apr 2002 | pmid = 12007534 | doi = 10.1016/S0014-2999(02)01427-9 }}
*{{cite journal | author=Wan CP, Lau BH |title=Neuropeptide Y receptor subtypes. |journal=Life Sci. |volume=56 |issue= 13 |pages= 1055-64 |year= 1997 |pmid= 9001438 |doi= }}
* {{cite journal | vauthors = Bettio A, Beck-Sickinger AG | title = Biophysical methods to study ligand-receptor interactions of neuropeptide Y | journal = Biopolymers | volume = 60 | issue = 6 | pages = 420–37 | year = 2002 | pmid = 12209475 | doi = 10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W }}
*{{cite journal | author=Parker E, Van Heek M, Stamford A |title=Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status. |journal=Eur. J. Pharmacol. |volume=440 |issue= 2-3 |pages= 173-87 |year= 2002 |pmid= 12007534 |doi= }}
* {{cite journal | vauthors = Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlested C | title = Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type | journal = The Journal of Biological Chemistry | volume = 267 | issue = 16 | pages = 10935–8 | date = Jun 1992 | pmid = 1317848 | doi =  }}
*{{cite journal | author=Bettio A, Beck-Sickinger AG |title=Biophysical methods to study ligand-receptor interactions of neuropeptide Y. |journal=Biopolymers |volume=60 |issue= 6 |pages= 420-37 |year= 2002 |pmid= 12209475 |doi= 10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W }}
* {{cite journal | vauthors = Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA | title = Cloned human neuropeptide Y receptor couples to two different second messenger systems | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 13 | pages = 5794–8 | date = Jul 1992 | pmid = 1321422 | pmc = 402104 | doi = 10.1073/pnas.89.13.5794 }}
*{{cite journal | author=Larhammar D, Blomqvist AG, Yee F, ''et al.'' |title=Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. |journal=J. Biol. Chem. |volume=267 |issue= 16 |pages= 10935-8 |year= 1992 |pmid= 1317848 |doi=  }}
* {{cite journal | vauthors = Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R | title = Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor | journal = The Journal of Biological Chemistry | volume = 270 | issue = 39 | pages = 22661–4 | date = Sep 1995 | pmid = 7559383 | doi = 10.1074/jbc.270.39.22661 }}
*{{cite journal | author=Herzog H, Hort YJ, Ball HJ, ''et al.'' |title=Cloned human neuropeptide Y receptor couples to two different second messenger systems. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 13 |pages= 5794-8 |year= 1992 |pmid= 1321422 |doi= }}
* {{cite journal | vauthors = Gicquiaux H, Lecat S, Gaire M, Dieterlen A, Mély Y, Takeda K, Bucher B, Galzi JL | title = Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 8 | pages = 6645–55 | date = Feb 2002 | pmid = 11741903 | doi = 10.1074/jbc.M107224200 }}
*{{cite journal | author=Rose PM, Fernandes P, Lynch JS, ''et al.'' |title=Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. |journal=J. Biol. Chem. |volume=270 |issue= 39 |pages= 22661-4 |year= 1995 |pmid= 7559383 |doi= }}
* {{cite journal | vauthors = Sheriff S, F Qureshy A, T Chance W, Kasckow JW, Balasubramaniam A | title = Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected] | journal = Peptides | volume = 23 | issue = 1 | pages = 87–96 | date = Jan 2002 | pmid = 11814622 | doi = 10.1016/S0196-9781(01)00583-6 }}
*{{cite journal  | author=Herzog H, Baumgartner M, Vivero C, ''et al.'' |title=Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor. |journal=J. Biol. Chem. |volume=268 |issue= 9 |pages= 6703-7 |year= 1993 |pmid= 8095935 |doi=  }}
* {{cite journal | vauthors = Cox HM, Tough IR | title = Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa | journal = British Journal of Pharmacology | volume = 135 | issue = 6 | pages = 1505–12 | date = Mar 2002 | pmid = 11906964 | pmc = 1573267 | doi = 10.1038/sj.bjp.0704604 }}
*{{cite journal | author=Gicquiaux H, Lecat S, Gaire M, ''et al.'' |title=Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6645-55 |year= 2002 |pmid= 11741903 |doi= 10.1074/jbc.M107224200 }}
* {{cite journal | vauthors = Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L | title = Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues | journal = Peptides | volume = 23 | issue = 5 | pages = 927–34 | date = May 2002 | pmid = 12084524 | doi = 10.1016/S0196-9781(02)00003-7 }}
*{{cite journal | author=Sheriff S, F Qureshy A, T Chance W, ''et al.'' |title=Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]. |journal=Peptides |volume=23 |issue= 1 |pages= 87-96 |year= 2002 |pmid= 11814622 |doi= }}
* {{cite journal | vauthors = Cantó Soler MV, Gallo JE, Dodds RA, Hökfelt T, Villar MJ, Suburo AM | title = Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina | journal = Glia | volume = 39 | issue = 3 | pages = 320–4 | date = Sep 2002 | pmid = 12203398 | doi = 10.1002/glia.10107 }}
*{{cite journal | author=Cox HM, Tough IR |title=Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa. |journal=Br. J. Pharmacol. |volume=135 |issue= 6 |pages= 1505-12 |year= 2002 |pmid= 11906964 |doi= 10.1038/sj.bjp.0704604 }}
* {{cite journal | vauthors = Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR | title = The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 306 | issue = 1 | pages = 147–56 | date = Jul 2003 | pmid = 12665544 | doi = 10.1124/jpet.103.051227 }}
*{{cite journal | author=Uddman R, Möller S, Nilsson T, ''et al.'' |title=Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues. |journal=Peptides |volume=23 |issue= 5 |pages= 927-34 |year= 2003 |pmid= 12084524 |doi= }}
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = Jul 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
*{{cite journal | author=Cantó Soler MV, Gallo JE, Dodds RA, ''et al.'' |title=Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina. |journal=Glia |volume=39 |issue= 3 |pages= 320-4 |year= 2002 |pmid= 12203398 |doi= 10.1002/glia.10107 }}
* {{cite journal | vauthors = Körner M, Waser B, Reubi JC | title = High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia | journal = Clinical Cancer Research | volume = 10 | issue = 24 | pages = 8426–33 | date = Dec 2004 | pmid = 15623622 | doi = 10.1158/1078-0432.CCR-04-0821 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Berglund MM, Schober DA, Statnick MA, ''et al.'' |title=The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction. |journal=J. Pharmacol. Exp. Ther. |volume=306 |issue= 1 |pages= 147-56 |year= 2003 |pmid= 12665544 |doi= 10.1124/jpet.103.051227 }}
*{{cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Körner M, Waser B, Reubi JC |title=High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia. |journal=Clin. Cancer Res. |volume=10 |issue= 24 |pages= 8426-33 |year= 2005 |pmid= 15623622 |doi= 10.1158/1078-0432.CCR-04-0821 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
== External links ==
{{G protein-coupled receptors}}
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2366 | title = Neuropeptide Y Receptors: Y<sub>1</sub> | accessdate = | author = | authorlink = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
 
{{transmembranereceptor-stub}}
{{G protein-coupled receptors|g1}}
{{Neuropeptidergics}}
 
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{WikiDoc Sources}}

Revision as of 00:57, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.[1][2]

Selective ligands

Agonists

Antagonists

Peptide
  • BVD-10 (selective NPY1 antagonist, CAS# 262418-00-8)
  • GR-231,118 (mixed NPY1 antagonist / NPY4 agonist, CAS# 158859-98-4)
Non-peptide
  • BIBO-3304 (CAS# 191868-14-1)
  • BIBP-3226 (CAS# 159013-54-4)
  • PD-160,170 (CAS# 181468-88-2)

See also

References

  1. ↑ Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (Mar 1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor". The Journal of Biological Chemistry. 268 (9): 6703–7. PMID 8095935.
  2. ↑ "Entrez Gene: NPY1R neuropeptide Y receptor Y1".

Further reading

External links

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