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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Neurotensin receptor type 2''' is a [[protein]] that in humans is encoded by the ''NTSR2'' [[gene]].<ref name="pmid8647296">{{cite journal | vauthors = Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D | title = Molecular cloning of a levocabastine-sensitive neurotensin binding site | journal = FEBS Letters | volume = 386 | issue = 2-3 | pages = 91–4 | date = May 1996 | pmid = 8647296 | pmc =  | doi = 10.1016/0014-5793(96)00397-3 }}</ref><ref name="pmid9851594">{{cite journal | vauthors = Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P | title = Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells | journal = European Journal of Pharmacology | volume = 360 | issue = 2-3 | pages = 265–72 | date = Nov 1998 | pmid = 9851594 | pmc = | doi = 10.1016/S0014-2999(98)00678-5 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NTSR2 neurotensin receptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23620| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Neurotensin receptor 2
| HGNCid = 8040
| Symbol = NTSR2
| AltSymbols =; NTR2
| OMIM = 605538
| ECnumber = 
| Homologene = 7452
| MGIid = 108018
| GeneAtlas_image1 = PBB_GE_NTSR2_206899_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0016492 |text = neurotensin receptor activity, G-protein coupled}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007600 |text = sensory perception}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23620
    | Hs_Ensembl = ENSG00000169006
    | Hs_RefseqProtein = XP_001129997
    | Hs_RefseqmRNA = XM_001129997
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 11715756
    | Hs_GenLoc_end = 11727706
    | Hs_Uniprot = O95665
    | Mm_EntrezGene = 18217
    | Mm_Ensembl = ENSMUSG00000020591
    | Mm_RefseqmRNA = NM_008747
    | Mm_RefseqProtein = NP_032773
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 16678980
    | Mm_GenLoc_end = 16685673
    | Mm_Uniprot = Q8VIF4
  }}
}}
'''Neurotensin receptor 2''', also known as '''NTSR2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NTSR2 neurotensin receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23620| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, [[levocabastine]], a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.<ref name="entrez">{{cite web | title = Entrez Gene: NTSR2 neurotensin receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23620| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Neurotensin receptor]]
* [[Neurotensin receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|33em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Vincent JP, Mazella J, Kitabgi P | title = Neurotensin and neurotensin receptors | journal = Trends in Pharmacological Sciences | volume = 20 | issue = 7 | pages = 302–9 | date = Jul 1999 | pmid = 10390649 | doi = 10.1016/S0165-6147(99)01357-7 }}
| citations =
* {{cite journal | vauthors = Mazella J, Botto JM, Guillemare E, Coppola T, Sarret P, Vincent JP | title = Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain | journal = The Journal of Neuroscience | volume = 16 | issue = 18 | pages = 5613–20 | date = Sep 1996 | pmid = 8795617 | doi =  }}
*{{cite journal | author=Vincent JP, Mazella J, Kitabgi P |title=Neurotensin and neurotensin receptors. |journal=Trends Pharmacol. Sci. |volume=20 |issue= 7 |pages= 302-9 |year= 1999 |pmid= 10390649 |doi= }}
* {{cite journal | vauthors = Ramez M, Bagot M, Nikolova M, Boumsell L, Vita N, Chalon P, Caput D, Ferrara P, Bensussan A | title = Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes | journal = The Journal of Investigative Dermatology | volume = 117 | issue = 3 | pages = 687–93 | date = Sep 2001 | pmid = 11564178 | doi = 10.1046/j.0022-202x.2001.01439.x }}
*{{cite journal  | author=Chalon P, Vita N, Kaghad M, ''et al.'' |title=Molecular cloning of a levocabastine-sensitive neurotensin binding site. |journal=FEBS Lett. |volume=386 |issue= 2-3 |pages= 91-4 |year= 1996 |pmid= 8647296 |doi=  }}
* {{cite journal | vauthors = Martin S, Vincent JP, Mazella J | title = Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue | journal = Journal of Cell Science | volume = 115 | issue = Pt 1 | pages = 165–73 | date = Jan 2002 | pmid = 11801734 | doi =  }}
*{{cite journal | author=Mazella J, Botto JM, Guillemare E, ''et al.'' |title=Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain. |journal=J. Neurosci. |volume=16 |issue= 18 |pages= 5613-20 |year= 1996 |pmid= 8795617 |doi=  }}
* {{cite journal | vauthors = Bourcier T, Rondeau N, Paquet S, Forgez P, Lombet A, Pouzaud F, Rostène W, Borderie V, Laroche L | title = Expression of neurotensin receptors in human corneal keratocytes | journal = Investigative Ophthalmology & Visual Science | volume = 43 | issue = 6 | pages = 1765–71 | date = Jun 2002 | pmid = 12036977 | doi =  }}
*{{cite journal | author=Vita N, Oury-Donat F, Chalon P, ''et al.'' |title=Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells. |journal=Eur. J. Pharmacol. |volume=360 |issue= 2-3 |pages= 265-72 |year= 1999 |pmid= 9851594 |doi=  }}
* {{cite journal | vauthors = Leyton J, Garcia-Marin L, Jensen RT, Moody TW | title = Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells | journal = European Journal of Pharmacology | volume = 442 | issue = 3 | pages = 179–86 | date = May 2002 | pmid = 12065070 | doi = 10.1016/S0014-2999(02)01539-X }}
*{{cite journal  | author=Ramez M, Bagot M, Nikolova M, ''et al.'' |title=Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes. |journal=J. Invest. Dermatol. |volume=117 |issue= 3 |pages= 687-93 |year= 2001 |pmid= 11564178 |doi= 10.1046/j.0022-202x.2001.01439.x }}
* {{cite journal | vauthors = Somaï S, Gompel A, Rostène W, Forgez P | title = Neurotensin counteracts apoptosis in breast cancer cells | journal = Biochemical and Biophysical Research Communications | volume = 295 | issue = 2 | pages = 482–8 | date = Jul 2002 | pmid = 12150975 | doi = 10.1016/S0006-291X(02)00703-9 }}
*{{cite journal | author=Martin S, Vincent JP, Mazella J |title=Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue. |journal=J. Cell. Sci. |volume=115 |issue= Pt 1 |pages= 165-73 |year= 2002 |pmid= 11801734 |doi=  }}
* {{cite journal | vauthors = Holst B, Holliday ND, Bach A, Elling CE, Cox HM, Schwartz TW | title = Common structural basis for constitutive activity of the ghrelin receptor family | journal = The Journal of Biological Chemistry | volume = 279 | issue = 51 | pages = 53806–17 | date = Dec 2004 | pmid = 15383539 | doi = 10.1074/jbc.M407676200 }}
*{{cite journal | author=Bourcier T, Rondeau N, Paquet S, ''et al.'' |title=Expression of neurotensin receptors in human corneal keratocytes. |journal=Invest. Ophthalmol. Vis. Sci. |volume=43 |issue= 6 |pages= 1765-71 |year= 2002 |pmid= 12036977 |doi=  }}
*{{cite journal | author=Leyton J, Garcia-Marin L, Jensen RT, Moody TW |title=Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells. |journal=Eur. J. Pharmacol. |volume=442 |issue= 3 |pages= 179-86 |year= 2002 |pmid= 12065070 |doi= }}
*{{cite journal | author=Somaï S, Gompel A, Rostène W, Forgez P |title=Neurotensin counteracts apoptosis in breast cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 2 |pages= 482-8 |year= 2002 |pmid= 12150975 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Holst B, Holliday ND, Bach A, ''et al.'' |title=Common structural basis for constitutive activity of the ghrelin receptor family. |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53806-17 |year= 2005 |pmid= 15383539 |doi= 10.1074/jbc.M407676200 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors|g1}}
{{Neuropeptidergics}}
 
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3005 | title = Neurotensin Receptors: NTS<sub>2</sub> | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
 
 
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{WikiDoc Sources}}
 
{{transmembranereceptor-stub}}

Revision as of 00:59, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.[1][2][3]

Function

The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.[3]

See also

References

  1. ↑ Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D (May 1996). "Molecular cloning of a levocabastine-sensitive neurotensin binding site". FEBS Letters. 386 (2–3): 91–4. doi:10.1016/0014-5793(96)00397-3. PMID 8647296.
  2. ↑ Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P (Nov 1998). "Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells". European Journal of Pharmacology. 360 (2–3): 265–72. doi:10.1016/S0014-2999(98)00678-5. PMID 9851594.
  3. ↑ 3.0 3.1 "Entrez Gene: NTSR2 neurotensin receptor 2".

Further reading

  • Vincent JP, Mazella J, Kitabgi P (Jul 1999). "Neurotensin and neurotensin receptors". Trends in Pharmacological Sciences. 20 (7): 302–9. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649.
  • Mazella J, Botto JM, Guillemare E, Coppola T, Sarret P, Vincent JP (Sep 1996). "Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain". The Journal of Neuroscience. 16 (18): 5613–20. PMID 8795617.
  • Ramez M, Bagot M, Nikolova M, Boumsell L, Vita N, Chalon P, Caput D, Ferrara P, Bensussan A (Sep 2001). "Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes". The Journal of Investigative Dermatology. 117 (3): 687–93. doi:10.1046/j.0022-202x.2001.01439.x. PMID 11564178.
  • Martin S, Vincent JP, Mazella J (Jan 2002). "Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue". Journal of Cell Science. 115 (Pt 1): 165–73. PMID 11801734.
  • Bourcier T, Rondeau N, Paquet S, Forgez P, Lombet A, Pouzaud F, Rostène W, Borderie V, Laroche L (Jun 2002). "Expression of neurotensin receptors in human corneal keratocytes". Investigative Ophthalmology & Visual Science. 43 (6): 1765–71. PMID 12036977.
  • Leyton J, Garcia-Marin L, Jensen RT, Moody TW (May 2002). "Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells". European Journal of Pharmacology. 442 (3): 179–86. doi:10.1016/S0014-2999(02)01539-X. PMID 12065070.
  • Somaï S, Gompel A, Rostène W, Forgez P (Jul 2002). "Neurotensin counteracts apoptosis in breast cancer cells". Biochemical and Biophysical Research Communications. 295 (2): 482–8. doi:10.1016/S0006-291X(02)00703-9. PMID 12150975.
  • Holst B, Holliday ND, Bach A, Elling CE, Cox HM, Schwartz TW (Dec 2004). "Common structural basis for constitutive activity of the ghrelin receptor family". The Journal of Biological Chemistry. 279 (51): 53806–17. doi:10.1074/jbc.M407676200. PMID 15383539.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


External links

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