Cholecystokinin A receptor

Cholecystokinin A receptor
PDB rendering based on 1d6g.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1d6g​
Identifiers
Symbols	CCKAR ; CCK-A; CCK1-R; CCKRA
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37337
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cholecystokinin A receptor, also known as CCKAR, is a human gene.

This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine.

See also

• Cholecystokinin receptor
• Cholecystokinin antagonist

Further reading

• Varga G, Bálint A, Burghardt B, D'Amato M (2004). "Involvement of endogenous CCK and CCK1 receptors in colonic motor function". Br. J. Pharmacol. 141 (8): 1275–84. doi:10.1038/sj.bjp.0705769. PMID 15100163.CS1 maint: Multiple names: authors list (link)
• Miller LJ, Holicky EL, Ulrich CD, Wieben ED (1995). "Abnormal processing of the human cholecystokinin receptor gene in association with gallstones and obesity". Gastroenterology. 109 (4): 1375–80. PMID 7557108.CS1 maint: Multiple names: authors list (link)
• Huppi K, Siwarski D, Pisegna JR, Wank S (1995). "Chromosomal localization of the gastric and brain receptors for cholecystokinin (CCKAR and CCKBR) in human and mouse". Genomics. 25 (3): 727–9. PMID 7759110.CS1 maint: Multiple names: authors list (link)
• de Weerth A, Pisegna JR, Huppi K, Wank SA (1993). "Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor". Biochem. Biophys. Res. Commun. 194 (2): 811–8. PMID 8343165.CS1 maint: Multiple names: authors list (link)
• Ulrich CD, Ferber I, Holicky E; et al. (1993). "Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor". Biochem. Biophys. Res. Commun. 193 (1): 204–11. doi:10.1006/bbrc.1993.1610. PMID 8503909.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kennedy K, Gigoux V, Escrieut C; et al. (1997). "Identification of two amino acids of the human cholecystokinin-A receptor that interact with the N-terminal moiety of cholecystokinin". J. Biol. Chem. 272 (5): 2920–6. PMID 9006937.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inoue H, Iannotti CA, Welling CM; et al. (1997). "Human cholecystokinin type A receptor gene: cytogenetic localization, physical mapping, and identification of two missense variants in patients with obesity and non-insulin-dependent diabetes mellitus (NIDDM)". Genomics. 42 (2): 331–5. doi:10.1006/geno.1997.4749. PMID 9192855.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gigoux V, Escrieut C, Silvente-Poirot S; et al. (1998). "Met-195 of the cholecystokinin-A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor transition to high affinity state". J. Biol. Chem. 273 (23): 14380–6. PMID 9603948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Funakoshi A, Fukamizu Y, Miyasaka K (2000). "Mechanism of cholecystokinin-A- receptor antagonist on human pancreatic exocrine secretion. Localization of CCK-A receptor in the human duodenum". Digestion. 60 Suppl 1: 75–80. PMID 10026437.CS1 maint: Multiple names: authors list (link)
• Gigoux V, Escrieut C, Fehrentz JA; et al. (1999). "Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin". J. Biol. Chem. 274 (29): 20457–64. PMID 10400673.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pellegrini M, Mierke DF (1999). "Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy". Biochemistry. 38 (45): 14775–83. PMID 10555959.
• Gigoux V, Maigret B, Escrieut C; et al. (2000). "Arginine 197 of the cholecystokinin-A receptor binding site interacts with the sulfate of the peptide agonist cholecystokinin". Protein Sci. 8 (11): 2347–54. PMID 10595537.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Funakoshi A, Miyasaka K, Matsumoto H; et al. (2000). "Gene structure of human cholecystokinin (CCK) type-A receptor: body fat content is related to CCK type-A receptor gene promoter polymorphism". FEBS Lett. 466 (2–3): 264–6. PMID 10682840.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tachikawa H, Harada S, Kawanishi Y; et al. (2000). "Novel polymorphisms of the human cholecystokinin A receptor gene: an association analysis with schizophrenia". Am. J. Med. Genet. 96 (2): 141–5. PMID 10893485.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Giragossian C, Mierke DF (2001). "Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin A receptor". Biochemistry. 40 (13): 3804–9. PMID 11300760.
• Schmitz F, Schrader H, Otte J; et al. (2002). "Identification of CCK-B/gastrin receptor splice variants in human peripheral blood mononuclear cells". Regul. Pept. 101 (1–3): 25–33. PMID 11495676.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tachikawa H, Harada S, Kawanishi Y; et al. (2002). "Linked polymorphisms (-333G>T and -286A>G) in the promoter region of the CCK-A receptor gene may be associated with schizophrenia". Psychiatry research. 103 (2–3): 147–55. PMID 11549403.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schmitz F, Göke MN, Otte JM; et al. (2002). "Cellular expression of CCK-A and CCK-B/gastrin receptors in human gastric mucosa". Regul. Pept. 102 (2–3): 101–10. PMID 11730982.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okubo T, Harada S, Higuchi S, Matsushita S (2003). "Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism". Alcohol. Clin. Exp. Res. 26 (8 Suppl): 2S–5S. doi:10.1097/01.ALC.0000026826.96191.FB. PMID 12198366.CS1 maint: Multiple names: authors list (link)
• Takata Y, Takeda S, Kawanami T; et al. (2003). "Promoter analysis of human cholecystokinin type-A receptor gene". J. Gastroenterol. 37 (10): 815–20. doi:10.1007/s005350200135. PMID 12424565.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.