Cholecystokinin receptor

Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin.^[1] There are two different subtypes CCK_A and CCK_B which are ~50% homologous:^[2] Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide.

protein	gene	tissue distribution	preferred ligand	function
CCK_A (CCK₁)	CCKAR	primarily gastrointestinal tract, lesser amounts in the CNS	sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK	stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility
CCK_B (CCK₂)	CCKBR	primarily CNS, lesser amounts in the gastrointestinal tract	gastrin ≈ CCK (receptor does not discriminate between sulfated and nonsulfated peptides)	regulation of nociception, anxiety, memory and hunger

References

↑ Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, Roques BP (December 1999). "International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors". Pharmacological Reviews. 51 (4): 745–81. PMID 10581329.
↑ Dufresne M, Seva C, Fourmy D (2006). "Cholecystokinin and gastrin receptors". Physiol. Rev. 86 (3): 805–47. doi:10.1152/physrev.00014.2005. PMID 16816139.

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