Cholecystokinin B receptor

Cholecystokinin B receptor
PDB rendering based on 1l4t.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1l4t​
Identifiers
Symbols	CCKBR ; CCK-B; GASR
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7258
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cholecystokinin B receptor, also known as CCKBR, is a human gene.

This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.

See also

• Cholecystokinin receptor
• Cholecystokinin antagonist

Further reading

• Herget T, Sethi T, Wu SV; et al. (1994). "Cholecystokinin stimulates Ca2+ mobilization and clonal growth in small cell lung cancer through CCKA and CCKB/gastrin receptors". Ann. N. Y. Acad. Sci. 713: 283–97. PMID 8185170.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pisegna JR, de Weerth A, Huppi K, Wank SA (1992). "Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization". Biochem. Biophys. Res. Commun. 189 (1): 296–303. PMID 1280419.CS1 maint: Multiple names: authors list (link)
• Lee YM, Beinborn M, McBride EW; et al. (1993). "The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization". J. Biol. Chem. 268 (11): 8164–9. PMID 7681836.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ito M, Iwata N, Taniguchi T; et al. (1995). "Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: a preferential splice donor site in the human receptor gene". Cell Growth Differ. 5 (10): 1127–35. PMID 7848914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyake A (1995). "A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon". Biochem. Biophys. Res. Commun. 208 (1): 230–7. doi:10.1006/bbrc.1995.1328. PMID 7887934.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Zimonjic DB, Popescu NC, Matsui T; et al. (1993). "Localization of the human cholecystokinin-B/gastrin receptor gene (CCKBR) to chromosome 11p15.5-->p15.4 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 65 (3): 184–5. PMID 8222757.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Weerth A, Pisegna JR, Huppi K, Wank SA (1993). "Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor". Biochem. Biophys. Res. Commun. 194 (2): 811–8. PMID 8343165.CS1 maint: Multiple names: authors list (link)
• Ito M, Matsui T, Taniguchi T; et al. (1993). "Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin". J. Biol. Chem. 268 (24): 18300–5. PMID 8349705.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Song I, Brown DR, Wiltshire RN; et al. (1993). "The human gastrin/cholecystokinin type B receptor gene: alternative splice donor site in exon 4 generates two variant mRNAs". Proc. Natl. Acad. Sci. U.S.A. 90 (19): 9085–9. PMID 8415658.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beinborn M, Lee YM, McBride EW; et al. (1993). "A single amino acid of the cholecystokinin-B/gastrin receptor determines specificity for non-peptide antagonists". Nature. 362 (6418): 348–50. doi:10.1038/362348a0. PMID 8455720.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Silvente-Poirot S, Wank SA (1996). "A segment of five amino acids in the second extracellular loop of the cholecystokinin-B receptor is essential for selectivity of the peptide agonist gastrin". J. Biol. Chem. 271 (25): 14698–706. PMID 8663021.
• Tarasova NI, Wank SA, Hudson EA; et al. (1997). "Endocytosis of gastrin in cancer cells expressing gastrin/CCK-B receptor". Cell Tissue Res. 287 (2): 325–33. PMID 8995203.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• O'Briant KC, Ali SY, Weier HU, Bepler G (1999). "An 84-kilobase physical map and repeat polymorphisms of the gastrin/cholecystokinin brain receptor region at the junction of chromosome segments 11p15.4 and 15.5". Chromosome Res. 6 (5): 415–8. PMID 9872672.CS1 maint: Multiple names: authors list (link)
• Monstein HJ, Nilsson I, Ellnebo-Svedlund K, Svensson SP (1999). "Cloning and characterization of 5'-end alternatively spliced human cholecystokinin-B receptor mRNAs". Recept. Channels. 6 (3): 165–77. PMID 10100325.CS1 maint: Multiple names: authors list (link)
• Daulhac L, Kowalski-Chauvel A, Pradayrol L; et al. (1999). "Src-family tyrosine kinases in activation of ERK-1 and p85/p110-phosphatidylinositol 3-kinase by G/CCKB receptors". J. Biol. Chem. 274 (29): 20657–63. PMID 10400698.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Silvente-Poirot S, Escrieut C, Galès C; et al. (1999). "Evidence for a direct interaction between the penultimate aspartic acid of cholecystokinin and histidine 207, located in the second extracellular loop of the cholecystokinin B receptor". J. Biol. Chem. 274 (33): 23191–7. PMID 10438490.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kulaksiz H, Arnold R, Göke B; et al. (2000). "Expression and cell-specific localization of the cholecystokinin B/gastrin receptor in the human stomach". Cell Tissue Res. 299 (2): 289–98. PMID 10741470.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.