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{{Infobox_gene}}
'''Frizzled-10''' is a [[protein]] that in humans is encoded by the ''FZD10'' [[gene]].<ref name="pmid10448064">{{cite journal | vauthors = Koike J, Takagi A, Miwa T, Hirai M, Terada M, Katoh M | title = Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family | journal = Biochemical and Biophysical Research Communications | volume = 262 | issue = 1 | pages = 39–43 | date = Aug 1999 | pmid = 10448064 | pmc =  | doi = 10.1006/bbrc.1999.1161 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FZD10 frizzled homolog 10 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11211| accessdate = }}</ref> FZD10 has also been designated as '''CD350''' ([[cluster of differentiation]] 350).


== Function ==


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This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.<ref name="entrez" />
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Frizzled homolog 10 (Drosophila)
| HGNCid = 4039
| Symbol = FZD10
| AltSymbols =; FZ-10; FzE7; hFz10
| OMIM = 606147
| ECnumber = 
| Homologene = 21411
| MGIid = 2136761
| GeneAtlas_image1 = PBB_GE_FZD10_219764_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004926 |text = non-G-protein coupled 7TM receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0042813 |text = Wnt receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007222 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11211
    | Hs_Ensembl = ENSG00000111432
    | Hs_RefseqProtein = NP_009128
    | Hs_RefseqmRNA = NM_007197
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 129212957
    | Hs_GenLoc_end = 129216237
    | Hs_Uniprot = Q9ULW2
    | Mm_EntrezGene = 93897
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_974070
    | Mm_RefseqProtein = XP_979164
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Frizzled homolog 10 (Drosophila)''', also known as '''FZD10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FZD10 frizzled homolog 10 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11211| accessdate = }}</ref> FZD10 has also been designated as '''CD350''' ([[cluster of differentiation]] 350).
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.<ref name="entrez">{{cite web | title = Entrez Gene: FZD10 frizzled homolog 10 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11211| accessdate = }}</ref>
}}
 
==See also==
* [[Frizzled]]
* [[Frizzled]]


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS | title = Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 13 | pages = 6770–5 | date = Jun 1997 | pmid = 9192640 | pmc = 21233 | doi = 10.1073/pnas.94.13.6770 }}
| citations =
* {{cite journal | vauthors = Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K | title = A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 17 | pages = 10164–9 | date = Aug 1998 | pmid = 9707618 | pmc = 21479 | doi = 10.1073/pnas.95.17.10164 }}
*{{cite journal | author=Finch PW, He X, Kelley MJ, ''et al.'' |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770-5 |year= 1997 |pmid= 9192640 |doi= }}
* {{cite journal | vauthors = Kumar S, Connor JR, Dodds RA, Halsey W, Van Horn M, Mao J, Sathe G, Mui P, Agarwal P, Badger AM, Lee JC, Gowen M, Lark MW | title = Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries | journal = Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society | volume = 9 | issue = 7 | pages = 641–53 | date = Oct 2001 | pmid = 11597177 | doi = 10.1053/joca.2001.0421 }}
*{{cite journal | author=Tanaka S, Akiyoshi T, Mori M, ''et al.'' |title=A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10164-9 |year= 1998 |pmid= 9707618 |doi= }}
* {{cite journal | vauthors = Terasaki H, Saitoh T, Shiokawa K, Katoh M | title = Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway | journal = International Journal of Molecular Medicine | volume = 9 | issue = 2 | pages = 107–12 | date = Feb 2002 | pmid = 11786918 | doi = 10.3892/ijmm.9.2.107 }}
*{{cite journal  | author=Koike J, Takagi A, Miwa T, ''et al.'' |title=Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 1 |pages= 39-43 |year= 1999 |pmid= 10448064 |doi= 10.1006/bbrc.1999.1161 }}
* {{cite journal | vauthors = Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y | title = Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) | journal = Ophthalmic Genetics | volume = 25 | issue = 2 | pages = 81–90 | date = Jun 2004 | pmid = 15370539 | doi = 10.1080/13816810490514270 }}
*{{cite journal | author=Kumar S, Connor JR, Dodds RA, ''et al.'' |title=Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries. |journal=Osteoarthr. Cartil. |volume=9 |issue= 7 |pages= 641-53 |year= 2001 |pmid= 11597177 |doi= 10.1053/joca.2001.0421 }}
*{{cite journal | author=Terasaki H, Saitoh T, Shiokawa K, Katoh M |title=Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway. |journal=Int. J. Mol. Med. |volume=9 |issue= 2 |pages= 107-12 |year= 2002 |pmid= 11786918 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Omoto S, Hayashi T, Kitahara K, ''et al.'' |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81-90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3068 | title = Frizzled Receptors: FZD<sub>10</sub> | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
* {{MeshName|FZD10+protein,+human}}
* {{MeshName|FZD10+protein,+human}}


{{transmembranereceptor-stub}}
{{NLM content}}
{{NLM content}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors|g4}}


[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
[[Category:G protein coupled receptors]]
[[Category:G protein-coupled receptors]]
 
{{WH}}
{{WS}}

Latest revision as of 18:00, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Frizzled-10 is a protein that in humans is encoded by the FZD10 gene.[1][2] FZD10 has also been designated as CD350 (cluster of differentiation 350).

Function

This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.[2]

See also

References

  1. ↑ Koike J, Takagi A, Miwa T, Hirai M, Terada M, Katoh M (Aug 1999). "Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family". Biochemical and Biophysical Research Communications. 262 (1): 39–43. doi:10.1006/bbrc.1999.1161. PMID 10448064.
  2. ↑ 2.0 2.1 "Entrez Gene: FZD10 frizzled homolog 10 (Drosophila)".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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