FZD10
| Frizzled homolog 10 (Drosophila) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | FZD10 ; FZ-10; FzE7; hFz10 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 21411 | ||||||||||
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| Orthologs | |||||||||||
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| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Frizzled homolog 10 (Drosophila), also known as FZD10, is a human gene.[1] FZD10 has also been designated as CD350 (cluster of differentiation 350).
This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.[1]
See also
References
Further reading
- Finch PW, He X, Kelley MJ; et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. PMID 9192640.
- Tanaka S, Akiyoshi T, Mori M; et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. PMID 9707618.
- Koike J, Takagi A, Miwa T; et al. (1999). "Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family". Biochem. Biophys. Res. Commun. 262 (1): 39–43. doi:10.1006/bbrc.1999.1161. PMID 10448064.
- Kumar S, Connor JR, Dodds RA; et al. (2001). "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries". Osteoarthr. Cartil. 9 (7): 641–53. doi:10.1053/joca.2001.0421. PMID 11597177.
- Terasaki H, Saitoh T, Shiokawa K, Katoh M (2002). "Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway". Int. J. Mol. Med. 9 (2): 107–12. PMID 11786918.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Omoto S, Hayashi T, Kitahara K; et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
External links
- FZD10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.