Calcitriol

Calcitriol is the active form of vitamin D, normally made in the kidney.^[1]^[2]^[3] It is also known as 1,25-dihydroxycholecalciferol. It is a hormone which binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes.^[4] Calcitriol increases blood calcium (Ca²⁺) mainly by increasing the uptake of calcium from the intestines.^[5]

References

↑ Plum LA, DeLuca HF (December 2010). "Vitamin D, disease and therapeutic opportunities". Nature Reviews. Drug Discovery. 9 (12): 941–955. doi:10.1038/nrd3318. PMID 21119732.
↑ Encyclopedia of Endocrine Diseases. Academic Press. 2018. p. 344. ISBN 9780128122006.
↑ "Office of Dietary Supplements - Vitamin D". ods.od.nih.gov. 9 October 2020. Retrieved 31 October 2020.
↑ Norman AW (August 2008). "From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health". The American Journal of Clinical Nutrition. 88 (2): 491S–499S. doi:10.1093/ajcn/88.2.491S. PMID 18689389.
↑ "Calcitriol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 9 April 2019.

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