Zap1p gene transcriptions

Associate Editor(s)-in-Chief: Henry A. Hoff

"Zinc homeostasis in yeast is controlled primarily through the regulation of zinc uptake. Transcription of the ZRT1 and ZRT2 zinc transporters increases in zinc-limited cells, and this induction is dependent on the ZAP1 gene. [...] Expression of ZAP1 itself increases in zinc-limited cells. [Zinc-responsive elements] (ZREs) [are] in the promoters of the ZRT1, ZRT2, and ZAP1 genes. A ZRE consensus sequence, 5'-ACCYYNAAGGT-3', was identified and found to be both necessary and sufficient for zinc-responsive transcriptional regulation. [...] ZREs are DNA binding sites for ZAP1."^[1]

Human genes

Consensus sequences

The upstream activating sequence (UAS) for Zap1p is 5'-ACC(C/T)(C/T)(A/C/G/T)AAGGT-3' in the promoters of ZRT1 and ZRT2 regarding this zinc-regulated transcription factor [67].^[2]

Hypotheses

A1BG has no regulatory elements in either promoter.
A1BG is not transcribed by a regulatory element.
No regulatory element participates in the transcription of A1BG.

ZAP samplings

Copying the apparent consensus sequence for Zap1p (ACCCTCA) and putting it in "⌘F" finds none located between ZSCAN22 and none between ZNF497 and A1BG as can be found by the computer programs.

For the Basic programs (starting with SuccessablesZAP.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are looking for, and found:

negative strand, negative direction, looking for ACC(C/T)(C/T)NAAGGT, 0.
positive strand, negative direction, looking for ACC(C/T)(C/T)NAAGGT, 0.
positive strand, positive direction, looking for ACC(C/T)(C/T)NAAGGT, 0.
negative strand, positive direction, looking for ACC(C/T)(C/T)NAAGGT, 0.
complement, negative strand, negative direction, looking for TGG(A/G)(A/G)NTTCCA, 0.
complement, positive strand, negative direction, looking for TGG(A/G)(A/G)NTTCCA, 0.
complement, positive strand, positive direction, looking for TGG(A/G)(A/G)NTTCCA, 0.
complement, negative strand, positive direction, looking for TGG(A/G)(A/G)NTTCCA, 0.
inverse complement, negative strand, negative direction, looking for ACCTTN(A/G)(A/G)GGT, 0.
inverse complement, positive strand, negative direction, looking for ACCTTN(A/G)(A/G)GGT, 0.
inverse complement, positive strand, positive direction, looking for ACCTTN(A/G)(A/G)GGT, 0.
inverse complement, negative strand, positive direction, looking for ACCTTN(A/G)(A/G)GGT, 0.
inverse negative strand, negative direction, looking for TGGAAN(C/T)(C/T)CCA, 0.
inverse positive strand, negative direction, looking for TGGAAN(C/T)(C/T)CCA, 0.
inverse positive strand, positive direction, looking for TGGAAN(C/T)(C/T)CCA, 0.
inverse negative strand, positive direction, looking for TGGAAN(C/T)(C/T)CCA, 0.

Acknowledgements

The content on this page was first contributed by: Henry A. Hoff.

References

↑ Hui Zhao, Edward Butler, Jacquelyn Rodgers, Thomas Spizzo, Sara Duesterhoeft and David Eide (30 November 1998). "Regulation of zinc homeostasis in yeast by binding of the ZAP1 transcriptional activator to zinc-responsive promoter elements". Journal of Biological Chemistry. 273 (44): 28713–20. doi:10.1074/jbc.273.44.28713. PMID 9786867. Retrieved 15 March 2021.
↑ Hongting Tang, Yanling Wu, Jiliang Deng, Nanzhu Chen, Zhaohui Zheng, Yongjun Wei, Xiaozhou Luo, and Jay D. Keasling (6 August 2020). "Promoter Architecture and Promoter Engineering in Saccharomyces cerevisiae". Metabolites. 10 (8): 320–39. doi:10.3390/metabo10080320. PMID 32781665 Check |pmid= value (help). Retrieved 18 September 2020.

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