Spaceflight gene expressions

Associate Editor(s)-in-Chief: Henry A. Hoff

In these images are a Dual Energy X-ray Absorptiometry (DEXA) scans of a human hip bone, left, and a human spine, right. Credit: Thomas Lang, University of California in San Francisco, NASA.

Gene expressions is a suite of genes, and their isoforms, that appear to be biochemically involved in the appearance of a trait.

Space travel changes the way genes are expressed.^[1]

"NASA’s Twins Study preliminary results have revealed that space travel causes an increase in methylation, the process of turning genes on and off, and additional knowledge in how that process works."^[2]

"Some of the most exciting things that we’ve seen from looking at gene expression in space is that we really see an explosion, like fireworks taking off, as soon as the human body gets into space. With this study, we’ve seen thousands and thousands of genes change how they are turned on and turned off. This happens as soon as an astronaut gets into space, and some of the activity persists temporarily upon return to Earth."^[3]

"This study represents one of the most comprehensive views of human biology. It really sets the bedrock for understanding molecular risks for space travel as well as ways to potentially protect and fix those genetic changes."^[3]

The image on the right shows the loss of bone mass apparently due to long-term microgravity on the International Space Station. "[A]stronauts, on average, lost roughly 11 percent of their total hip bone mass over the course of their mission."^[4]

Human genes

Gene ID: 249 ALPL alkaline phosphatase, liver/bone/kidney, alias bone alkaline phosphatase (BAP).

Gene ID: 348 APOE apolipoprotein E, one isoform (the gene itself), 19q13.32. "The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants."^[5]

Gene ID: 1277 COL1A1 collagen type I alpha 1, i.e., type 1 procollagen propeptide, procollagen C-telopeptide.

Gene ID: 5741 PTH parathyroid hormone.

Gene ID: 7415 VCP valosin-containing protein.

Gene ID: 9370 ADIPOQ adiponectin, C1Q and collagen domain containing, i.e., free and bound deoxypyridinoline.

Hypotheses

The transcription of each gene, or its isoforms, is the opportunity to influence under or over expression.

References

↑ Christopher E. Mason (24 October 2017). "NASA Finds Space Travel Changes the Way Genes are Expressed". Washington, DC USA: NASA. Retrieved 2017-10-27.
↑ Amy Blanchett and Laurie Abadie (24 October 2017). "Fireworks in Space: NASA's Twins Study Explores Gene Expression". Washington, DC USA: NASA. Retrieved 2017-10-27.
↑ ^3.0 ^3.1 Christopher E. Mason (24 October 2017). "Fireworks in Space: NASA's Twins Study Explores Gene Expression". Washington, DC USA: NASA. Retrieved 2017-10-27.
↑ Steve Roy (26 February 2007). "How Long Does It Take to Rebuild Bone Lost During Space Flight?". Washington, DC USA: NASA. Retrieved 2018-04-12.
↑ RefSeq (June 2016). "APOE apolipoprotein E [ Homo sapiens (human) ]". 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 27 March 2022.

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Spaceflight gene expressions

Contents

Human genes

Hypotheses

See also

References

External links

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