C-EBP box gene transcriptions

Associate Editor(s)-in-Chief: Henry A. Hoff

"ATF4 regulates transcription of its target genes through the formation of homodimers or heterooligomers with the transcription factors Jun, AP-1 and C/EBP^38,39 that bind to CARE (C/EBP-ATF) responsive elements having the consensus sequence XTTXCATCA (where X = G, A or T).³⁹ In the region from -625 to -618 bp relative to the SESN2 translation start codon (from -228 to -221 bp relative to the transcription start site) we found a candidate sequence for the ATF4 binding site TTTTCATCA."^[1]

Consensus sequences

The consensus sequence for the CCAAT-enhancer-binding site (C/EBP) is TAGCATT (Yao).^[2]

"TTAGGACAT [Misra] is the C/EBP box".^[3]

Hypotheses

A1BG has no A boxes in either promoter.
A1BG is not transcribed by an ATA box.
AGCE1 does not participate in the transcription of A1BG.

C/EBP boxes samplings

TTAGGACAT (Misra) is a C/EBP box that does not occur in either promoter of A1BG using "⌘F".

For the Basic programs testing consensus sequence 5'-TTAGGACAT-3' (starting with SuccessablesAAA.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:

negative strand, negative direction, looking for 5'-TTAGGACAT-3', 0.
negative strand, positive direction, looking for 5'-TTAGGACAT-3', 0.
positive strand, negative direction, looking for 5'-TTAGGACAT-3', 0.
positive strand, positive direction, looking for 5'-TTAGGACAT-3', 0.
complement, negative strand, negative direction, looking for 5'-AATCCTGTA-3', 0.
complement, negative strand, positive direction, looking for 5'-AATCCTGTA-3', 0.
complement, positive strand, negative direction, looking for 5'-AATCCTGTA-3', 0.
complement, positive strand, positive direction, looking for 5'-AATCCTGTA-3', 0.
inverse complement, negative strand, negative direction, looking for 5'-ATGTCCTAA-3', 0.
inverse complement, negative strand, positive direction, looking for 5'-ATGTCCTAA-3', 0.
inverse complement, positive strand, negative direction, looking for 5'-ATGTCCTAA-3', 0.
inverse complement, positive strand, positive direction, looking for 5'-ATGTCCTAA-3', 0.
inverse negative strand, negative direction, looking for 5'-TACAGGATT-3', 0.
inverse negative strand, positive direction, looking for 5'-TACAGGATT-3', 0.
inverse positive strand, negative direction, looking for 5'-TACAGGATT-3', 0.
inverse positive strand, positive direction, looking for 5'-TACAGGATT-3', 0.

TAGCATT (Yao) is a C/EBP box that does not occur in either promoter of A1BG using "⌘F".

For the Basic programs testing consensus sequence 5'-TAGCATT-3' (starting with SuccessablesAAA.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:

negative strand, negative direction, looking for 5'-TAGCATT-3', 0.
negative strand, positive direction, looking for 5'-TAGCATT-3', 0.
positive strand, negative direction, looking for 5'-TAGCATT-3', 0.
positive strand, positive direction, looking for 5'-TAGCATT-3', 0.
complement, negative strand, negative direction, looking for 5'-ATCGTAA-3', 0.
complement, negative strand, positive direction, looking for 5'-ATCGTAA-3', 0.
complement, positive strand, negative direction, looking for 5'-ATCGTAA-3', 0.
complement, positive strand, positive direction, looking for 5'-ATCGTAA-3', 0.
inverse complement, negative strand, negative direction, looking for 5'-AATGCTA-3', 0.
inverse complement, negative strand, positive direction, looking for 5'-AATGCTA-3', 0.
inverse complement, positive strand, negative direction, looking for 5'-AATGCTA-3', 0.
inverse complement, positive strand, positive direction, looking for 5'-AATGCTA-3', 0.
inverse negative strand, negative direction, looking for 5'-TTACGAT-3', 0.
inverse negative strand, positive direction, looking for 5'-TTACGAT-3', 0.
inverse positive strand, negative direction, looking for 5'-TTACGAT-3', 0.
inverse positive strand, positive direction, looking for 5'-TTACGAT-3', 0.

Acknowledgements

The content on this page was first contributed by: Henry A. Hoff.

References

↑ Alisa A. Garaeva, Irina E. Kovaleva, Peter M. Chumakov & Alexandra G. Evstafieva (15 January 2016). "Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4". Cell Cycle. 15 (1): 64–71. doi:10.1080/15384101.2015.1120929. PMID 26771712. Retrieved 5 September 2020.
↑ Yao EF, Denison MS (June 1992). "DNA sequence determinants for binding of transformed Ah receptor to a dioxin-responsive enhancer". Biochemistry. 31 (21): 5060–7. doi:10.1021/bi00136a019. PMID 1318077.
↑ Ravi P. Misra, Azad Bonni, Cindy K. Miranti, Victor M. Rivera, Morgan Sheng, and Michael E.Greenberg (14 October 1994). "L-type Voltage-sensitive Calcium Channel Activation Stimulates Gene Expression by a Serum Response Factor-dependent Pathway" (PDF). The Journal of Biological Chemistry. 269 (41): 25483–25493. PMID 7929249. Retrieved 7 December 2019.

External links

[Garaeva-1] Alisa A. Garaeva, Irina E. Kovaleva, Peter M. Chumakov & Alexandra G. Evstafieva (15 January 2016). "Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4". Cell Cycle. 15 (1): 64–71. doi:10.1080/15384101.2015.1120929. PMID 26771712. Retrieved 5 September 2020.

[Yao-2] Yao EF, Denison MS (June 1992). "DNA sequence determinants for binding of transformed Ah receptor to a dioxin-responsive enhancer". Biochemistry. 31 (21): 5060–7. doi:10.1021/bi00136a019. PMID 1318077.

[Misra-3] Ravi P. Misra, Azad Bonni, Cindy K. Miranti, Victor M. Rivera, Morgan Sheng, and Michael E.Greenberg (14 October 1994). "L-type Voltage-sensitive Calcium Channel Activation Stimulates Gene Expression by a Serum Response Factor-dependent Pathway" (PDF). The Journal of Biological Chemistry. 269 (41): 25483–25493. PMID 7929249. Retrieved 7 December 2019.

[1]

[2]

[3]

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transcriptions Shoot specific element gene transcriptions Sip4p gene transcriptions Smp1p gene transcriptions Sp1 gene transcriptions Spaceflight gene expressions Specificity protein gene transcriptions STAT gene transcriptions Ste12p gene transcriptions Sterol response element gene transcriptions Sucrose box gene transcriptions Synaptic Activity-Responsive Elements TACTAAC box gene transcriptions TAGteam gene transcriptions Tapetum box gene transcriptions TATA binding protein associated factor gene transcriptions TATA binding protein gene transcriptions TATA box actin/cytoskeleton/contractile family TATA box albumin family TATA box aldolase family TATA box alkaline phosphatase family TATA box annexin family TATA box cytochrome superfamily TATA box gene transcriptions TATA box heat shock family TATA box histone family TATA box human genes TATA box keratin family TATA box lipase family TATA box peptidase family TATA box platelet-derived growth factor family TATA box selenium-binding 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