Hypoxia-inducible factor gene transcriptions: Difference between revisions
Jump to navigation
Jump to search
Created page with "{{AE}} Henry A. Hoff "HIF-1 is a heterodimeric transcription factor composed of HIF-1α and HIF-1β [27]."<ref name=Li2020>{{ cite journal |author=Qingliang Li, Rezaul M. Kar..." |
|||
Line 25: | Line 25: | ||
==Samplings== | ==Samplings== | ||
{{main|Model samplings}} | |||
Copying a portion of the consensus sequence for the HIF of GCCCTACGT and putting it in "⌘F" finds none located between ZSCAN22 and A1BG and none between ZNF497 and A1BG as can be found by the computer programs. | |||
For the Basic programs testing consensus sequence GCCCTACGT (starting with SuccessablesHIF.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found: | |||
# negative strand, negative direction, looking for AAAAAAAA, 0. | |||
# negative strand, positive direction, looking for AAAAAAAA, 0. | |||
# positive strand, negative direction, looking for AAAAAAAA, 0. | |||
# positive strand, positive direction, looking for AAAAAAAA, 0. | |||
# complement, negative strand, negative direction, looking for TTTTTTTT, 0. | |||
# complement, negative strand, positive direction, looking for TTTTTTTT, 0. | |||
# complement, positive strand, negative direction, looking for TTTTTTTT, 0. | |||
# complement, positive strand, positive direction, looking for TTTTTTTT, 0. | |||
# inverse complement, negative strand, negative direction, looking for TTTTTTTT, 0. | |||
# inverse complement, negative strand, positive direction, looking for TTTTTTTT, 0. | |||
# inverse complement, positive strand, negative direction, looking for TTTTTTTT, 0. | |||
# inverse complement, positive strand, positive direction, looking for TTTTTTTT, 0. | |||
# inverse negative strand, negative direction, looking for AAAAAAAA, 0. | |||
# inverse negative strand, positive direction, looking for AAAAAAAA, 0. | |||
# inverse positive strand, negative direction, looking for AAAAAAAA, 0. | |||
# inverse positive strand, positive direction, looking for AAAAAAAA, 0. | |||
===HIF core promoters=== | |||
{{main|Core promoter gene transcriptions}} | |||
===HIF proximal promoters=== | |||
{{main|Proximal promoter gene transcriptions}} | |||
===HIF distal promoters=== | |||
{{main|Distal promoter gene transcriptions}} | |||
==See also== | ==See also== |
Revision as of 04:13, 27 January 2021
Associate Editor(s)-in-Chief: Henry A. Hoff
"HIF-1 is a heterodimeric transcription factor composed of HIF-1α and HIF-1β [27]."[1]
Human genes
Interactions
Consensus sequences
The binding site for HIF-1 is GCCCTACGTGCTGTCTCA.[1]
Samplings
Copying a portion of the consensus sequence for the HIF of GCCCTACGT and putting it in "⌘F" finds none located between ZSCAN22 and A1BG and none between ZNF497 and A1BG as can be found by the computer programs.
For the Basic programs testing consensus sequence GCCCTACGT (starting with SuccessablesHIF.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:
- negative strand, negative direction, looking for AAAAAAAA, 0.
- negative strand, positive direction, looking for AAAAAAAA, 0.
- positive strand, negative direction, looking for AAAAAAAA, 0.
- positive strand, positive direction, looking for AAAAAAAA, 0.
- complement, negative strand, negative direction, looking for TTTTTTTT, 0.
- complement, negative strand, positive direction, looking for TTTTTTTT, 0.
- complement, positive strand, negative direction, looking for TTTTTTTT, 0.
- complement, positive strand, positive direction, looking for TTTTTTTT, 0.
- inverse complement, negative strand, negative direction, looking for TTTTTTTT, 0.
- inverse complement, negative strand, positive direction, looking for TTTTTTTT, 0.
- inverse complement, positive strand, negative direction, looking for TTTTTTTT, 0.
- inverse complement, positive strand, positive direction, looking for TTTTTTTT, 0.
- inverse negative strand, negative direction, looking for AAAAAAAA, 0.
- inverse negative strand, positive direction, looking for AAAAAAAA, 0.
- inverse positive strand, negative direction, looking for AAAAAAAA, 0.
- inverse positive strand, positive direction, looking for AAAAAAAA, 0.
HIF core promoters
HIF proximal promoters
HIF distal promoters
See also
References
- ↑ 1.0 1.1 Qingliang Li, Rezaul M. Karim, Mo Cheng, Mousumi Das, Lihong Chen, Chen Zhang, Harshani R. Lawrence, Gary W. Daughdrill, Ernst Schonbrunn, Haitao Ji and Jiandong Chen (July 2020). "Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity". Oncogene. 39 (29): 5187–5200. doi:10.1038/s41388-020-1344-y. PMID 32555331 Check
|pmid=
value (help). Retrieved 29 August 2020.