Antioxidant-electrophile responsive element gene transcriptions: Difference between revisions
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|accessdate=6 October 2020 }}</ref>, an antioxidant response element (ARE). | |accessdate=6 October 2020 }}</ref>, an antioxidant response element (ARE). | ||
==Hypotheses== | |||
{{main|Hypotheses}} | |||
# A1BG has no Antioxidant-electrophile responsive element in either promoter. | |||
# A1BG is not transcribed by an Antioxidant-electrophile responsive element. | |||
# Antioxidant-electrophile responsive element does not participate in the transcription of A1BG. | |||
==Samplings== | ==Samplings== | ||
Copying an antioxidant-electrophile responsive elements consensus sequence 5'-GTGAGGTCGC-3' and putting the sequence in "⌘F" finds no location between ZNF497 and A1BG or none locations between ZSCAN22 and A1BG as can be found by the computer programs. Copying 5'-GCTGAGT-3', 5'-GCAGGCT-3' of 5'-GC(A/C/T)(A/G/T)(A/G/T)(C/G/T)T(A/C)A-3' and putting the sequence in "⌘F" finds no location between ZNF497 and A1BG or none locations between ZSCAN22 and A1BG as can be found by the computer programs. | Copying an antioxidant-electrophile responsive elements consensus sequence 5'-GTGAGGTCGC-3' and putting the sequence in "⌘F" finds no location between ZNF497 and A1BG or none locations between ZSCAN22 and A1BG as can be found by the computer programs. Copying 5'-GCTGAGT-3', 5'-GCAGGCT-3' of 5'-GC(A/C/T)(A/G/T)(A/G/T)(C/G/T)T(A/C)A-3' and putting the sequence in "⌘F" finds no location between ZNF497 and A1BG or none locations between ZSCAN22 and A1BG as can be found by the computer programs. | ||
For the Basic programs testing consensus sequence 5'-GCTGAGTCA-3' (starting with SuccessablesAERE.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found: | |||
# negative strand, negative direction, looking for 5'-GCTGAGTCA-3', 0. | |||
# negative strand, positive direction, looking for 5'-GCTGAGTCA-3', 0. | |||
# positive strand, negative direction, looking for 5'-GCTGAGTCA-3', 0. | |||
# positive strand, positive direction, looking for 5'-GCTGAGTCA-3', 0. | |||
# complement, negative strand, negative direction, looking for 5'-TTTTTTTT-3', 0. | |||
# complement, negative strand, positive direction, looking for 5'-TTTTTTTT-3', 0. | |||
# complement, positive strand, negative direction, looking for 5'-TTTTTTTT-3', 0. | |||
# complement, positive strand, positive direction, looking for 5'-TTTTTTTT-3', 0. | |||
# inverse complement, negative strand, negative direction, looking for 5'-TTTTTTTT-3', 0. | |||
# inverse complement, negative strand, positive direction, looking for 5'-TTTTTTTT-3', 0. | |||
# inverse complement, positive strand, negative direction, looking for 5'-TTTTTTTT-3', 0. | |||
# inverse complement, positive strand, positive direction, looking for 5'-TTTTTTTT-3', 0. | |||
# inverse negative strand, negative direction, looking for 5'-AAAAAAAA-3', 0. | |||
# inverse negative strand, positive direction, looking for 5'-AAAAAAAA-3', 0. | |||
# inverse positive strand, negative direction, looking for 5'-AAAAAAAA-3', 0. | |||
# inverse positive strand, positive direction, looking for 5'-AAAAAAAA-3', 0. | |||
===AAA core promoters=== | |||
{{main|Core promoter gene transcriptions}} | |||
===AAA proximal promoters=== | |||
{{main|Proximal promoter gene transcriptions}} | |||
===AAA distal promoters=== | |||
{{main|Distal promoter gene transcriptions}} | |||
==See also== | ==See also== | ||
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[[Category:Resources last modified in | [[Category:Resources last modified in November 2020]] |
Revision as of 06:06, 4 November 2020
Associate Editor(s)-in-Chief: Henry A. Hoff
The "perfect ARE sequence [GCTGAGTCA] is strongly conserved across mammals [...]."[1]
Consensus sequences
5'-GTGAGGTCGC-3'[2]
5'-GCTGAGT-3', 5'-GCAGGCT-3' of 5'-GC(A/C/T)(A/G/T)(A/G/T)(C/G/T)T(A/C)A-3'[1], an antioxidant response element (ARE).
Hypotheses
- A1BG has no Antioxidant-electrophile responsive element in either promoter.
- A1BG is not transcribed by an Antioxidant-electrophile responsive element.
- Antioxidant-electrophile responsive element does not participate in the transcription of A1BG.
Samplings
Copying an antioxidant-electrophile responsive elements consensus sequence 5'-GTGAGGTCGC-3' and putting the sequence in "⌘F" finds no location between ZNF497 and A1BG or none locations between ZSCAN22 and A1BG as can be found by the computer programs. Copying 5'-GCTGAGT-3', 5'-GCAGGCT-3' of 5'-GC(A/C/T)(A/G/T)(A/G/T)(C/G/T)T(A/C)A-3' and putting the sequence in "⌘F" finds no location between ZNF497 and A1BG or none locations between ZSCAN22 and A1BG as can be found by the computer programs.
For the Basic programs testing consensus sequence 5'-GCTGAGTCA-3' (starting with SuccessablesAERE.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:
- negative strand, negative direction, looking for 5'-GCTGAGTCA-3', 0.
- negative strand, positive direction, looking for 5'-GCTGAGTCA-3', 0.
- positive strand, negative direction, looking for 5'-GCTGAGTCA-3', 0.
- positive strand, positive direction, looking for 5'-GCTGAGTCA-3', 0.
- complement, negative strand, negative direction, looking for 5'-TTTTTTTT-3', 0.
- complement, negative strand, positive direction, looking for 5'-TTTTTTTT-3', 0.
- complement, positive strand, negative direction, looking for 5'-TTTTTTTT-3', 0.
- complement, positive strand, positive direction, looking for 5'-TTTTTTTT-3', 0.
- inverse complement, negative strand, negative direction, looking for 5'-TTTTTTTT-3', 0.
- inverse complement, negative strand, positive direction, looking for 5'-TTTTTTTT-3', 0.
- inverse complement, positive strand, negative direction, looking for 5'-TTTTTTTT-3', 0.
- inverse complement, positive strand, positive direction, looking for 5'-TTTTTTTT-3', 0.
- inverse negative strand, negative direction, looking for 5'-AAAAAAAA-3', 0.
- inverse negative strand, positive direction, looking for 5'-AAAAAAAA-3', 0.
- inverse positive strand, negative direction, looking for 5'-AAAAAAAA-3', 0.
- inverse positive strand, positive direction, looking for 5'-AAAAAAAA-3', 0.
AAA core promoters
AAA proximal promoters
AAA distal promoters
See also
References
- ↑ 1.0 1.1 Sarah E. Lacher, Daniel C. Levings, Samuel Freeman, Matthew Slattery (October 2018). "Identification of a functional antioxidant response element at the HIF1A locus". Redox Biology. 19: 401–411. doi:10.1016/j.redox.2018.08.014. Retrieved 6 October 2020.
- ↑ Akihito Otsuki, Mikiko Suzuki, Fumiki Katsuoka, Kouhei Tsuchida, Hiromi Suda, Masanobu Morita, Ritsuko Shimizu, Masayuki Yamamoto (February 2016). "Unique cistrome defined as CsMBE is strictly required for Nrf2-sMaf heterodimer function in cytoprotection". Free Radical Biology and Medicine. 91: 45–57. doi:10.1016/j.freeradbiomed.2015.12.005. PMID 26677805. Retrieved 21 August 2020.
Acknowledgements
The content on this page was first contributed by: Henry A. Hoff.