GATA gene transcriptions: Difference between revisions
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"A computer search for transcription promoter elements [...] showed the presence of a prominent TATA box 22 nucleotides upstream of the transcription start site and an Sp1 site at position -42 to -33. The 5'-flanking sequence also contains three E boxes with CANNTG consensus sequences at positions -464 to -459, -90 to -85, and -52 to -47 that have been marked as E box, E1 box, and E2 box, respectively [...]. In addition, the 5'-flanking region contains one or more GRE, XRE, GATA-1, GCN-4, PEA-3, AP1, and AP2 consensus motifs and also three imperfect CArG sites [...]."<ref name=Lenka>{{ cite journal | |||
|author=Nibedita Lenka, Aruna Basu, Jayati Mullick, and Narayan G. Avadhani | |||
|title=The role of an E box binding basic helix loop helix protein in the cardiac muscle-specific expression of the rat cytochrome oxidase subunit VIII gene | |||
|journal=The Journal of Biological Chemistry | |||
|date=22 November 1996 | |||
|volume=271 | |||
|issue=47 | |||
|pages=30281–30289 | |||
|url=http://www.jbc.org/content/271/47/30281.full.pdf | |||
|arxiv= | |||
|bibcode= | |||
|doi=10.1074/jbc.271.47.30281 | |||
|pmid= | |||
|accessdate=7 February 2019 }}</ref> | |||
==See also== | ==See also== | ||
Revision as of 03:05, 30 December 2019
Associate Editor(s)-in-Chief: Henry A. Hoff
Although "the P3, P6 substitutions alter the conserved 'GATAAG' I box motif, a 'GATA' motif is present in the introduced EcoRV site. This introduced GATA sequence clearly does not serve as a functional I box [...]."[1]
"The I-box motif, 5'-GGATGAGATAAGA-3', or its shorter version 5'-GATAAG-3', has been found in the promoters of a large number of RBCS genes (Giuliano et al., 1988; Manzara and Gruissem, 1988). A related motif (the GATA box) is present in the promoters of the light-regulated chlorophyll a/b binding protein (CAB) genes of different species (Gidoni et al., 1989), and has been shown to be involved in the activation of an Arabidopsis CAB gene by light and by the circadian clock (Anderson and Kay, 1995). I-box and GATA binding factors have been identified in nuclear extracts from tobacco and tomato leaves and cotyledons (Borello et al., 1993; Giuliano et al., 1988; Manzara et al., 1991; Schindler and Cashmore, 1990). The I-box has therefore been suggested to be involved in light-regulated and/or leaf-specific gene expression of photosynthetic genes (Manzara et al., 1991), but to date no I-box binding protein has been cloned from plants."[2]
SRF is important during the development of the embryo, as it has been linked to the formation of mesoderm.[3][4]
The Serum response factor (SRF) has been shown to interact with GATA4.[5][6]
Cell specific developmental expression is tightly controlled, but, once expressed, require no additional activation -- GATA transcription factor (GATA), hepatocyte nuclear factors (HNF), PIT-1, MyoD, Myf5, Hox, winged-helix transcription factors.
The class of diverse Cys4 zinc fingers includes the family of GATA-factors.
In the diagram on the right, STAT5 may be involved with an erythropoiesis receptor, or Epo Receptor. Murine, members of the subfamily Murinae, Epo Receptor truncations and known functions are included. Erythroid differentiation depends on transcriptional regulator GATA1, zinc finger DNA binding domain binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements. In erythropoiesis, EpoR is best known for inducing survival of progenitors.
Some "putative wound-response elements including AGC box-like sequences28, TCA motif-like sequences28, carrot extensin gene wound-response elements (AT-rich motif, TTTTTTT, TGACGT)29, constitutive PAL footprint and elicitor-inducible PAL footprint31, and proteinase inhibitor II footprint31 have been found in cabch29 promoter. Some cis-elements related to organ and tissue-specific expression such as GATA motif-like sequence, ASF-1 binding site-like elements also existed in 5′ upstream region. Meanwhile, some basic transcriptional regulatory cis-elements including G box-like and GC box-like elements are located in this region."[7]
"A computer search for transcription promoter elements [...] showed the presence of a prominent TATA box 22 nucleotides upstream of the transcription start site and an Sp1 site at position -42 to -33. The 5'-flanking sequence also contains three E boxes with CANNTG consensus sequences at positions -464 to -459, -90 to -85, and -52 to -47 that have been marked as E box, E1 box, and E2 box, respectively [...]. In addition, the 5'-flanking region contains one or more GRE, XRE, GATA-1, GCN-4, PEA-3, AP1, and AP2 consensus motifs and also three imperfect CArG sites [...]."[8]
See also
References
- ↑ Robert G. K. Donald and Anthony R. Cashmore (1990). "Mutation of either G box or I box sequences profoundly affects expression from the Arabidopsis rbcS‐1A promoter". The EMBO Journal. 9 (6): 1717–1726. doi:10.1002/j.1460-2075.1990.tb08295.x. Retrieved 8 November 2018.
- ↑ Annkatrin Rose, Iris Meier and Udo Wienand (28 October 1999). "The tomato I-box binding factor LeMYBI is a member of a novel class of Myb-like proteins". The Plant Journal. 20 (6): 641–652. doi:10.1046/j.1365-313X.1999.00638.x. Retrieved 8 November 2018.
- ↑ Sepulveda JL, Vlahopoulos S, Iyer D, Belaguli N, Schwartz RJ (July 2002). "Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity". J. Biol. Chem. 277 (28): 25775–82. doi:10.1074/jbc.M203122200. PMID 11983708.
- ↑ Barron MR, Belaguli NS, Zhang SX, Trinh M, Iyer D, Merlo X, Lough JW, Parmacek MS, Bruneau BG, Schwartz RJ (March 2005). "Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes". J. Biol. Chem. 280 (12): 11816–28. doi:10.1074/jbc.M412408200. PMID 15591049.
- ↑ Belaguli NS, Sepulveda JL, Nigam V, Charron F, Nemer M, Schwartz RJ (October 2000). "Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators". Mol. Cell. Biol. 20 (20): 7550–8. doi:10.1128/mcb.20.20.7550-7558.2000. PMC 86307. PMID 11003651.
- ↑ Morin S, Paradis P, Aries A, Nemer M (February 2001). "Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor". Mol. Cell. Biol. 21 (4): 1036–44. doi:10.1128/MCB.21.4.1036-1044.2001. PMC 99558. PMID 11158291.
- ↑ Guo Qing Tang, Yong Yan Bai & Shi Wei Loo (1 June 1996). "Functional properties of a cabbage chitinase promoter from cabbage (Brassica oleracea var. capitata)". Cell Research. 6 (9): 75–84. Retrieved 24 March 2019.
- ↑ Nibedita Lenka, Aruna Basu, Jayati Mullick, and Narayan G. Avadhani (22 November 1996). "The role of an E box binding basic helix loop helix protein in the cardiac muscle-specific expression of the rat cytochrome oxidase subunit VIII gene" (PDF). The Journal of Biological Chemistry. 271 (47): 30281–30289. doi:10.1074/jbc.271.47.30281. Retrieved 7 February 2019.