Calcineurin-responsive transcription factor gene transcriptions: Difference between revisions

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Created page with "{{AE}} Henry A. Hoff ==Human genes== ==Interactions== ==Consensus sequences== The upstream activating sequence for the calcineurin-responsive transcription factor (Crz1p)..."
 
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==Human genes==
==Human genes==
Gene ID: 1827 is RCAN1 regulator of calcineurin 1 on 21q22.12: "The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants."<ref name=RefSeq1827>{{ cite web
|author=RefSeq
|title=RCAN1 regulator of calcineurin 1 [ Homo sapiens (human) ]
|publisher=National Center for Biotechnology Information, U.S. National Library of Medicine
|location=8600 Rockville Pike, Bethesda MD, 20894 USA
|date=November 2013
|url=https://www.ncbi.nlm.nih.gov/gene/1827
|accessdate=6 November 2020 }}</ref>
# NP_001272318.1 calcipressin-1 isoform d: "Transcript Variant: This variant (4) uses an alternate 5' exon compared to variant 1. The resulting isoform (d) has a distinct N-terminus compared to isoform a."<ref name=RefSeq1827/>
# NP_001272320.2 calcipressin-1 isoform e: "Transcript Variant: This variant (5) uses an alternate promoter and 5' exon compared to variant 1. The resulting isoform (e) has a distinct N-terminus compared to isoform a."<ref name=RefSeq1827/>
# NP_001272321.1 calcipressin-1 isoform b: "Transcript Variant: This variant (6) uses an alternate promoter and 5' exon compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a."<ref name=RefSeq1827/>
# NP_001272322.1 calcipressin-1 isoform b: "Transcript Variant: This variant (7) uses an alternate promoter and 5' exon compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a."<ref name=RefSeq1827/>
# NP_001317945.1 calcipressin-1 isoform f.<ref name=RefSeq1827/>
# NP_004405.3 calcipressin-1 isoform a: "Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a)."<ref name=RefSeq1827/>
# NP_981962.1 calcipressin-1 isoform b: "Transcript Variant: This variant (2) uses an alternate 5' exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a."<ref name=RefSeq1827/>
# NP_981963.1 calcipressin-1 isoform c: "Transcript Variant: This variant (3) uses an alternate 5' exon compared to variant 1. The resulting isoform (c) has a distinct N-terminus compared to isoform a."<ref name=RefSeq1827/>


==Interactions==
==Interactions==

Revision as of 23:13, 6 November 2020

Associate Editor(s)-in-Chief: Henry A. Hoff

Human genes

Gene ID: 1827 is RCAN1 regulator of calcineurin 1 on 21q22.12: "The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants."[1]

  1. NP_001272318.1 calcipressin-1 isoform d: "Transcript Variant: This variant (4) uses an alternate 5' exon compared to variant 1. The resulting isoform (d) has a distinct N-terminus compared to isoform a."[1]
  2. NP_001272320.2 calcipressin-1 isoform e: "Transcript Variant: This variant (5) uses an alternate promoter and 5' exon compared to variant 1. The resulting isoform (e) has a distinct N-terminus compared to isoform a."[1]
  3. NP_001272321.1 calcipressin-1 isoform b: "Transcript Variant: This variant (6) uses an alternate promoter and 5' exon compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a."[1]
  4. NP_001272322.1 calcipressin-1 isoform b: "Transcript Variant: This variant (7) uses an alternate promoter and 5' exon compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a."[1]
  5. NP_001317945.1 calcipressin-1 isoform f.[1]
  6. NP_004405.3 calcipressin-1 isoform a: "Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a)."[1]
  7. NP_981962.1 calcipressin-1 isoform b: "Transcript Variant: This variant (2) uses an alternate 5' exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a."[1]
  8. NP_981963.1 calcipressin-1 isoform c: "Transcript Variant: This variant (3) uses an alternate 5' exon compared to variant 1. The resulting isoform (c) has a distinct N-terminus compared to isoform a."[1]

Interactions

Consensus sequences

The upstream activating sequence for the calcineurin-responsive transcription factor (Crz1p) is 5'-TG(A/C)GCCNC-3'.[2]

Samplings

Copying 5'-TGCGCCCC-3' in "⌘F" yields none between ZSCAN22 and A1BG and none between ZNF497 and A1BG as can be found by the computer programs.

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 RefSeq (November 2013). "RCAN1 regulator of calcineurin 1 [ Homo sapiens (human) ]". 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 6 November 2020.
  2. Hongting Tang, Yanling Wu, Jiliang Deng, Nanzhu Chen, Zhaohui Zheng, Yongjun Wei, Xiaozhou Luo, and Jay D. Keasling (6 August 2020). "Promoter Architecture and Promoter Engineering in Saccharomyces cerevisiae". Metabolites. 10 (8): 320–39. doi:10.3390/metabo10080320. PMID 32781665 Check |pmid= value (help). Retrieved 18 September 2020.

External links