Unfolded protein response element gene transcriptions: Difference between revisions
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The consensus sequence for UPRE is 5'-TGACGTG(G/A)-3'.<ref name=So/> | The consensus sequence for UPRE is 5'-TGACGTG(G/A)-3'.<ref name=So/> | ||
== | ==UPRE samplings== | ||
Copying the consensus UPRE: | Copying the consensus UPRE: TGACGTG(G/A) and putting the sequence in "⌘F" finds no locations between ZNF497 and A1BG or between ZSCAN22 and A1BG as can be found by the computer programs. | ||
For the Basic programs testing consensus sequence TGACGTG(G/A) (starting with SuccessablesUPR.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found: | |||
# negative strand, negative direction, looking for TGACGTG(G/A), 0. | |||
# positive strand, negative direction, looking for AAAAAAAA, 0. | |||
# positive strand, positive direction, looking for AAAAAAAA, 0. | |||
# negative strand, positive direction, looking for AAAAAAAA, 0. | |||
# complement, negative strand, negative direction, looking for ACTGCAC(C/T), 0. | |||
# complement, positive strand, negative direction, looking for TTTTTTTT, 0. | |||
# complement, positive strand, positive direction, looking for TTTTTTTT, 0. | |||
# complement, negative strand, positive direction, looking for TTTTTTTT, 0. | |||
# inverse complement, negative strand, negative direction, looking for (C/T)CACGTCA, 0. | |||
# inverse complement, positive strand, negative direction, looking for TTTTTTTT, 0. | |||
# inverse complement, positive strand, positive direction, looking for TTTTTTTT, 0. | |||
# inverse complement, negative strand, positive direction, looking for TTTTTTTT, 0. | |||
# inverse negative strand, negative direction, looking for (A/G)GTGCAGT, 0. | |||
# inverse positive strand, negative direction, looking for AAAAAAAA, 0. | |||
# inverse positive strand, positive direction, looking for AAAAAAAA, 0. | |||
# inverse negative strand, positive direction, looking for AAAAAAAA, 0. | |||
===UPRE UTRs=== | |||
{{main|UTR promoter gene transcriptions}} | |||
===UPRE core promoters=== | |||
{{main|Core promoter gene transcriptions}} | |||
===UPRE proximal promoters=== | |||
{{main|Proximal promoter gene transcriptions}} | |||
===UPRE distal promoters=== | |||
{{main|Distal promoter gene transcriptions}} | |||
==See also== | ==See also== |
Revision as of 02:30, 8 March 2021
Associate Editor(s)-in-Chief: Henry A. Hoff
X-box binding protein 1s "XBP1s binds to the [unfolded protein response] UPR element (UPRE) containing the consensus sequence TGACGTGG/A and regulates the transcription of target genes in a cell type- and condition-specific manner (Yamamoto et al., 2004)."[1]
Human genes
Consensus sequences
The consensus sequence for UPRE is 5'-TGACGTG(G/A)-3'.[1]
UPRE samplings
Copying the consensus UPRE: TGACGTG(G/A) and putting the sequence in "⌘F" finds no locations between ZNF497 and A1BG or between ZSCAN22 and A1BG as can be found by the computer programs.
For the Basic programs testing consensus sequence TGACGTG(G/A) (starting with SuccessablesUPR.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:
- negative strand, negative direction, looking for TGACGTG(G/A), 0.
- positive strand, negative direction, looking for AAAAAAAA, 0.
- positive strand, positive direction, looking for AAAAAAAA, 0.
- negative strand, positive direction, looking for AAAAAAAA, 0.
- complement, negative strand, negative direction, looking for ACTGCAC(C/T), 0.
- complement, positive strand, negative direction, looking for TTTTTTTT, 0.
- complement, positive strand, positive direction, looking for TTTTTTTT, 0.
- complement, negative strand, positive direction, looking for TTTTTTTT, 0.
- inverse complement, negative strand, negative direction, looking for (C/T)CACGTCA, 0.
- inverse complement, positive strand, negative direction, looking for TTTTTTTT, 0.
- inverse complement, positive strand, positive direction, looking for TTTTTTTT, 0.
- inverse complement, negative strand, positive direction, looking for TTTTTTTT, 0.
- inverse negative strand, negative direction, looking for (A/G)GTGCAGT, 0.
- inverse positive strand, negative direction, looking for AAAAAAAA, 0.
- inverse positive strand, positive direction, looking for AAAAAAAA, 0.
- inverse negative strand, positive direction, looking for AAAAAAAA, 0.
UPRE UTRs
UPRE core promoters
UPRE proximal promoters
UPRE distal promoters
See also
References
- ↑ 1.0 1.1 Jae-Seon So (31 August 2018). "Roles of Endoplasmic Reticulum Stress in Immune Responses". Molecules and Cells. 41 (8): 705–16. doi:10.14348/molcells.2018.0241. PMID 30078231. Retrieved 5 September 2020.