Unfolded protein response element gene transcriptions: Difference between revisions
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# complement, positive strand, positive direction, looking for ACTGCAC(C/T), 0. | # complement, positive strand, positive direction, looking for ACTGCAC(C/T), 0. | ||
# complement, negative strand, positive direction, looking for ACTGCAC(C/T), 2, ACTGCACC at 4343, ACTGCACC at 3322. | # complement, negative strand, positive direction, looking for ACTGCAC(C/T), 2, ACTGCACC at 4343, ACTGCACC at 3322. | ||
# inverse complement, negative strand, negative direction, looking for (C/T)CACGTCA, | # inverse complement, negative strand, negative direction, looking for (C/T)CACGTCA, 2, CCACGTCA at 2083, TCACGTCA at 1472. | ||
# inverse complement, positive strand, negative direction, looking for | # inverse complement, positive strand, negative direction, looking for (C/T)CACGTCA, 0. | ||
# inverse complement, positive strand, positive direction, looking for | # inverse complement, positive strand, positive direction, looking for (C/T)CACGTCA, 2, TCACGTCA at 2328, TCACGTCA at 2065. | ||
# inverse complement, negative strand, positive direction, looking for | # inverse complement, negative strand, positive direction, looking for (C/T)CACGTCA, 0. | ||
# inverse negative strand, negative direction, looking for (A/G)GTGCAGT, 0. | # inverse negative strand, negative direction, looking for (A/G)GTGCAGT, 0. | ||
# inverse positive strand, negative direction, looking for | # inverse positive strand, negative direction, looking for (A/G)GTGCAGT, 2, GGTGCAGT at 2083, AGTGCAGT at 1472. | ||
# inverse positive strand, positive direction, looking for | # inverse positive strand, positive direction, looking for (A/G)GTGCAGT, 0. | ||
# inverse negative strand, positive direction, looking for | # inverse negative strand, positive direction, looking for (A/G)GTGCAGT, 2, AGTGCAGT at 2328, AGTGCAGT at 2065. | ||
===UPRE UTRs=== | ===UPRE UTRs=== | ||
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{{main|Distal promoter gene transcriptions}} | {{main|Distal promoter gene transcriptions}} | ||
Negative strand, negative direction: TGACGTGA at 2426, TGACGTGA at 2000. | Negative strand, negative direction: TGACGTGA at 2426, TGACGTGA at 2000. | ||
Positive strand, negative direction: GGTGCAGT at 2083, AGTGCAGT at 1472. | |||
Negative strand, positive direction: AGTGCAGT at 2328, AGTGCAGT at 2065. | |||
Positive strand, positive direction: TGACGTGG at 3322. | Positive strand, positive direction: TGACGTGG at 3322. |
Revision as of 04:56, 8 March 2021
Associate Editor(s)-in-Chief: Henry A. Hoff
X-box binding protein 1s "XBP1s binds to the [unfolded protein response] UPR element (UPRE) containing the consensus sequence TGACGTGG/A and regulates the transcription of target genes in a cell type- and condition-specific manner (Yamamoto et al., 2004)."[1]
Human genes
Consensus sequences
The consensus sequence for UPRE is 5'-TGACGTG(G/A)-3'.[1]
UPRE samplings
Copying the consensus UPRE: TGACGTG(G/A) and putting the sequence in "⌘F" finds no locations between ZNF497 and A1BG or between ZSCAN22 and A1BG as can be found by the computer programs.
For the Basic programs testing consensus sequence TGACGTG(G/A) (starting with SuccessablesUPR.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:
- negative strand, negative direction, looking for TGACGTG(G/A), 4, TGACGTGA at 4340, TGACGTGG at 2761, TGACGTGA at 2426, TGACGTGA at 2000.
- positive strand, negative direction, looking for TGACGTG(G/A), 0.
- positive strand, positive direction, looking for TGACGTG(G/A), 2, TGACGTGG at 4343, TGACGTGG at 3322.
- negative strand, positive direction, looking for TGACGTG(G/A), 0.
- complement, negative strand, negative direction, looking for ACTGCAC(C/T), 0.
- complement, positive strand, negative direction, looking for ACTGCAC(C/T), 4, ACTGCACT at 4340, ACTGCACC at 2761, ACTGCACT at 2426, ACTGCACT at 2000.
- complement, positive strand, positive direction, looking for ACTGCAC(C/T), 0.
- complement, negative strand, positive direction, looking for ACTGCAC(C/T), 2, ACTGCACC at 4343, ACTGCACC at 3322.
- inverse complement, negative strand, negative direction, looking for (C/T)CACGTCA, 2, CCACGTCA at 2083, TCACGTCA at 1472.
- inverse complement, positive strand, negative direction, looking for (C/T)CACGTCA, 0.
- inverse complement, positive strand, positive direction, looking for (C/T)CACGTCA, 2, TCACGTCA at 2328, TCACGTCA at 2065.
- inverse complement, negative strand, positive direction, looking for (C/T)CACGTCA, 0.
- inverse negative strand, negative direction, looking for (A/G)GTGCAGT, 0.
- inverse positive strand, negative direction, looking for (A/G)GTGCAGT, 2, GGTGCAGT at 2083, AGTGCAGT at 1472.
- inverse positive strand, positive direction, looking for (A/G)GTGCAGT, 0.
- inverse negative strand, positive direction, looking for (A/G)GTGCAGT, 2, AGTGCAGT at 2328, AGTGCAGT at 2065.
UPRE UTRs
Negative strand, negative direction: TGACGTGA at 4340.
UPRE core promoters
Positive strand, positive direction: TGACGTGG at 4343.
UPRE proximal promoters
Negative strand, negative direction: TGACGTGG at 2761.
UPRE distal promoters
Negative strand, negative direction: TGACGTGA at 2426, TGACGTGA at 2000.
Positive strand, negative direction: GGTGCAGT at 2083, AGTGCAGT at 1472.
Negative strand, positive direction: AGTGCAGT at 2328, AGTGCAGT at 2065.
Positive strand, positive direction: TGACGTGG at 3322.
Acknowledgements
The content on this page was first contributed by: Henry A. Hoff.
See also
References
- ↑ 1.0 1.1 Jae-Seon So (31 August 2018). "Roles of Endoplasmic Reticulum Stress in Immune Responses". Molecules and Cells. 41 (8): 705–16. doi:10.14348/molcells.2018.0241. PMID 30078231. Retrieved 5 September 2020.