Antioxidant-electrophile responsive element gene transcriptions

Associate Editor(s)-in-Chief: Henry A. Hoff

The "perfect ARE sequence [GCTGAGTCA] is strongly conserved across mammals [...]."^[1]

Consensus sequences

5'-GTGAGGTCGC-3'^[2]

5'-GCTGAGT-3', 5'-GCAGGCT-3' of 5'-GC(A/C/T)(A/G/T)(A/G/T)(C/G/T)T(A/C)A-3'^[1], an antioxidant response element (ARE).

Hypotheses

A1BG has no Antioxidant-electrophile responsive element in either promoter.
A1BG is not transcribed by an Antioxidant-electrophile responsive element.
Antioxidant-electrophile responsive element does not participate in the transcription of A1BG.

AERE (Otsuki) samplings

Copying an antioxidant-electrophile responsive elements consensus sequence 5'-GTGAGGTCGC-3' and putting the sequence in "⌘F" finds no location between ZNF497 and A1BG or none locations between ZSCAN22 and A1BG as can be found by the computer programs.

For the Basic programs testing consensus sequence 5'-GTGAGGTCGC-3' (starting with SuccessablesAERE.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:

negative strand, negative direction, looking for 5'-GTGAGGTCGC-3', 0.
negative strand, positive direction, looking for 5'-GTGAGGTCGC-3', 0.
positive strand, negative direction, looking for 5'-GTGAGGTCGC-3', 0.
positive strand, positive direction, looking for 5'-GTGAGGTCGC-3', 0.
complement, negative strand, negative direction, looking for 5'-CACTCCAGCG-3', 0.
complement, negative strand, positive direction, looking for 5'-CACTCCAGCG-3', 0.
complement, positive strand, negative direction, looking for 5'-CACTCCAGCG-3', 0.
complement, positive strand, positive direction, looking for 5'-CACTCCAGCG-3', 0.
inverse complement, negative strand, negative direction, looking for 5'-GCGACCTCAC-3', 0.
inverse complement, negative strand, positive direction, looking for 5'-GCGACCTCAC-3', 0.
inverse complement, positive strand, negative direction, looking for 5'-GCGACCTCAC-3', 0.
inverse complement, positive strand, positive direction, looking for 5'-GCGACCTCAC-3', 0.
inverse negative strand, negative direction, looking for 5'-CGCTGGAGTG-3', 0.
inverse negative strand, positive direction, looking for 5'-CGCTGGAGTG-3', 0.
inverse positive strand, negative direction, looking for 5'-CGCTGGAGTG-3', 0.
inverse positive strand, positive direction, looking for 5'-CGCTGGAGTG-3', 0.

AERE (Lacher) samplings

Copying 5'-GCTGAGT-3', 5'-GCAGGCT-3' of 5'-GC(A/C/T)(A/G/T)(A/G/T)(C/G/T)T(A/C)A-3' and putting the sequence in "⌘F" finds no location between ZNF497 and A1BG or none locations between ZSCAN22 and A1BG as can be found by the computer programs.

For the Basic programs testing consensus sequence 5'-GTGAGGTCGC-3' (starting with SuccessablesAERE.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:

negative strand, negative direction, looking for 5'-GTGAGGTCGC-3', 0.
negative strand, positive direction, looking for 5'-GTGAGGTCGC-3', 0.
positive strand, negative direction, looking for 5'-GTGAGGTCGC-3', 0.
positive strand, positive direction, looking for 5'-GTGAGGTCGC-3', 0.
complement, negative strand, negative direction, looking for 5'-CACTCCAGCG-3', 0.
complement, negative strand, positive direction, looking for 5'-CACTCCAGCG-3', 0.
complement, positive strand, negative direction, looking for 5'-CACTCCAGCG-3', 0.
complement, positive strand, positive direction, looking for 5'-CACTCCAGCG-3', 0.
inverse complement, negative strand, negative direction, looking for 5'-GCGACCTCAC-3', 0.
inverse complement, negative strand, positive direction, looking for 5'-GCGACCTCAC-3', 0.
inverse complement, positive strand, negative direction, looking for 5'-GCGACCTCAC-3', 0.
inverse complement, positive strand, positive direction, looking for 5'-GCGACCTCAC-3', 0.
inverse negative strand, negative direction, looking for 5'-CGCTGGAGTG-3', 0.
inverse negative strand, positive direction, looking for 5'-CGCTGGAGTG-3', 0.
inverse positive strand, negative direction, looking for 5'-CGCTGGAGTG-3', 0.
inverse positive strand, positive direction, looking for 5'-CGCTGGAGTG-3', 0.

AERE (Lacher) core promoters

AERE (Lacher) proximal promoters

AERE (Lacher) distal promoters

References

↑ ^1.0 ^1.1 Sarah E. Lacher, Daniel C. Levings, Samuel Freeman, Matthew Slattery (October 2018). "Identification of a functional antioxidant response element at the HIF1A locus". Redox Biology. 19: 401–411. doi:10.1016/j.redox.2018.08.014. Retrieved 6 October 2020.
↑ Akihito Otsuki, Mikiko Suzuki, Fumiki Katsuoka, Kouhei Tsuchida, Hiromi Suda, Masanobu Morita, Ritsuko Shimizu, Masayuki Yamamoto (February 2016). "Unique cistrome defined as CsMBE is strictly required for Nrf2-sMaf heterodimer function in cytoprotection". Free Radical Biology and Medicine. 91: 45–57. doi:10.1016/j.freeradbiomed.2015.12.005. PMID 26677805. Retrieved 21 August 2020.

Acknowledgements

The content on this page was first contributed by: Henry A. Hoff.

External links

[Lacher-1] 1.0 ^1.1 Sarah E. Lacher, Daniel C. Levings, Samuel Freeman, Matthew Slattery (October 2018). "Identification of a functional antioxidant response element at the HIF1A locus". Redox Biology. 19: 401–411. doi:10.1016/j.redox.2018.08.014. Retrieved 6 October 2020.

[Otsuki-2] Akihito Otsuki, Mikiko Suzuki, Fumiki Katsuoka, Kouhei Tsuchida, Hiromi Suda, Masanobu Morita, Ritsuko Shimizu, Masayuki Yamamoto (February 2016). "Unique cistrome defined as CsMBE is strictly required for Nrf2-sMaf heterodimer function in cytoprotection". Free Radical Biology and Medicine. 91: 45–57. doi:10.1016/j.freeradbiomed.2015.12.005. PMID 26677805. Retrieved 21 August 2020.

[1]

[2]

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Downstream promoter element gene transcriptions Downstream TFIIB recognition element gene transcriptions DREB box gene transcriptions E2 box gene transcriptions EIF4E basal element gene transcriptions EIN3 binding site gene transcriptions Enhancer activity copy gene transcriptions E box gene transcriptions Element gene transcriptions Endoplasmic reticulum stress response element gene transcriptions Endosperm expression gene transcriptions Enhancer box gene transcriptions Estrogen response element gene transcriptions Ethylene responsive element gene transcriptions Families of TATA box genes F box gene transcriptions Focused promoter gene transcriptions Forkhead box gene transcriptions Fur box gene transcriptions GAAC element gene transcriptions Gal4p gene transcriptions Γ-interferon activated sequence gene transcriptions GARE gene transcriptions GA responsive complex gene transcriptions GATA gene transcriptions G box gene transcriptions GC box gene transcriptions GCC box gene 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transcriptions HMG box gene transcriptions HNF gene transcriptions Homeobox gene transcriptions Hsf1p gene transcriptions HY box gene transcriptions Hybrid C, A boxes Hybrid C, G boxes Hybrid C, T boxes Hypoxia-inducible factor gene transcriptions Hypoxia response elements I box gene transcriptions Immunoglobulin like domain containing family Initiator element gene transcriptions Initiator-like element gene transcriptions Inositol/choline-responsive elements Interaction gene transcriptions Interferon regulatory factors Inverse copy gene transcriptions Jasmonic acid-responsive element gene transcriptions K-boxes Kozak sequence gene transcriptions Kruppel-associated box gene transcriptions Krüppel-like factor gene transcriptions L box gene transcriptions Leu3 gene transcriptions M35 box gene transcriptions MADS box gene transcriptions Maf recognition element gene transcriptions M box gene transcriptions M-CAT boxes Mcm1 regulatory factor gene transcriptions Met3 gene transcriptions 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box lipase family TATA box peptidase family TATA box platelet-derived growth factor family TATA box selenium-binding family TATA box serine protease family TATA box serpin superfamily TATA box transforming growth factor superfamily TATA box trefoil family TATA box tumor necrosis factor superfamily TATA box zinc metalloenzyme family TAT box gene transcriptions TATC box gene transcriptions Tbf1 regulatory factor gene transcriptions T box gene transcriptions TCCACCATA element gene transcriptions TC element gene transcriptions TCT gene transcriptions TEA consensus sequence gene transcriptions Tec1p gene transcriptions Telomeric repeat DNA-binding factor gene transcriptions Tetradecanoylphorbol-13-acetate response element gene transcriptions TGF-β control elements (TCEs) TGF-β inhibitory elements (TIEs) Thyroid hormone response element gene transcriptions Transcriptional regulation Transcription bubble gene transcriptions Transcription factor gene transcriptions Transcription factor 3 gene transcriptions Transcription factory gene transcriptions Transcription start site gene transcriptions Translational control sequence gene transcriptions Tryptophan residue U box gene transcriptions Unfolded protein response element gene transcriptions Upstream repressor site 1 Upstream response element gene transcriptions Upstream stimulatory factor gene transcriptions UTR promoter gene transcriptions V and P box gene transcriptions V box gene transcriptions Vhr1p gene transcriptions Vitamin D response element gene transcriptions W box gene transcriptions X box gene transcriptions Xbp1p gene transcriptions X core promoter element gene transcriptions Xenobiotic response element gene transcriptions Xenobiotic responsive element gene transcriptions Yap1p,2p gene transcriptions Y box gene transcriptions YY1 gene transcriptions Zap1p gene transcriptions Z box gene transcriptions Zinc responsive element gene transcriptions

Antioxidant-electrophile responsive element gene transcriptions

Contents

Consensus sequences

Hypotheses

AERE (Otsuki) samplings

AERE (Lacher) samplings

AERE (Lacher) core promoters

AERE (Lacher) proximal promoters

AERE (Lacher) distal promoters

See also

References

Acknowledgements

External links

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Antioxidant-electrophile responsive element gene transcriptions

Consensus sequences

Hypotheses

AERE (Otsuki) samplings

AERE (Lacher) samplings

AERE (Lacher) core promoters

AERE (Lacher) proximal promoters

AERE (Lacher) distal promoters

See also

References

Acknowledgements

External links

Navigation menu

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