P53 response element gene transcriptions

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Associate Editor(s)-in-Chief: Henry A. Hoff

"The p53 REs are defined by two closely spaced decameric half-sites [consensus sequence: 5′-(RRRCWWGYYY)n(RRRCWWGYYY)-3′; R = A,G; W = A,T; Y = C,T; n = spacer of length 0–20 base pairs (bp)], and hundreds of them have been validated in human and mouse (1)."[1]

Human genes

Consensus sequences

An apparent consensus sequence for the p53RE is (A/G)(A/G)(A/G)C(A/T)(A/T)G(C/T)(C/T)(C/T).

Samplings

Copying an apparent consensus sequence for the p53RE (GGGCATGCCT) and putting it in "⌘F" finds none located between ZSCAN22 and none between ZNF497 and A1BG as can be found by the computer programs.

See also

References

  1. Xiaojun Zhang, Ana Carolina Dantas Machado, Yuan Ding, Yongheng Chen, Yan Lu, Yankun Duan, Kenneth W. Tham, Lin Chen, Remo Rohs, Peter Z. Qin (1 February 2014). "Conformations of p53 response elements in solution deduced using site-directed spin labeling and Monte Carlo sampling". Nucleic Acids Research. 42 (4): 2789–2797. doi:10.1093/nar/gkt1219. PMID 24293651. Retrieved 28 August 2020.

External links