U box gene transcriptions
Associate Editor(s)-in-Chief: Henry A. Hoff
"The U box is a domain of ∼70 amino acids that is present in proteins from yeast to humans."[1]
"The prototype U box protein, yeast Ufd2, was identified as a ubiquitin chain assembly factor that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin-protein ligase (E3) to catalyze ubiquitin chain formation on artificial substrates."[1]
"The UFD2 protein and its homologs in other eukaryotes share a conserved domain designated the ‘U box’."[2]
"The U box mediates the interaction of UFD2 with ubiquitin conjugated proteins [...] the U box is a derived version of the RING-finger domain that lacks the hallmark metal-chelating residues of the latter [5,6] but is likely to function similarly to the RING-finger in mediating ubiquitin-conjugation of protein substrates."[2]
See also
References
- ↑ 1.0 1.1 Shigetsugu Hatakeyama, Masayoshi Yada, Masaki Matsumoto, Noriko Ishida and Kei-Ichi Nakayama (2001). "U Box Proteins as a New Family of Ubiquitin-Protein Ligases". The Journal of Biological Chemistry. 276: 33111–20. doi:10.1074/jbc.M102755200. Retrieved 2014-06-16. Unknown parameter
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ignored (help)CS1 maint: Multiple names: authors list (link) - ↑ 2.0 2.1 L. Aravind and Eugene V. Koonin (2000). "The U box is a modified RING finger — a common domain in ubiquitination". Current Biology. 10 (4): R132–4.
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