Forkhead box gene transcriptions

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Associate Editor(s)-in-Chief: Henry A. Hoff

"Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional regulators, which control a wide spectrum of biological processes."[1]

Human genes

Interactions

Consensus sequences

"Most paralogous FOX proteins bind to the canonical DNA response element 5′-RYAAAYA-3′ (R = A or G, Y = C or T)11–13."[2]

"Forkhead box protein O1 (FOXO1), a master transcriptional factor for gluconeogenesis in the liver, directly regulates TXNIP expression through the binding of the promoter region of TXNIP which contains a conserved consensus sequence, ′GTAAACAA′, of the FOXO binding site [100,101]."[3]

Samplings

Copying an apparent consensus sequence of 5'-(A/G)(C/T)AAA(C/T)A-3' and putting it in "⌘F" finds none located between ZSCAN22 and A1BG and none between ZNF497 and A1BG as can be found by the computer programs.

Diseases

The "deregulation of Fox family transcription factors has a crucial role in the development and progression of cancer".[1]

See also

References

  1. 1.0 1.1 Stephen S. Myatt & Eric W. -F. Lam (2007). "The emerging roles of forkhead box (Fox) proteins in cancer". Nature Reviews Cancer. 7: 847–859. doi:10.1038/nrc2223. Retrieved 2017-02-13. Unknown parameter |month= ignored (help)
  2. Jun Li, Ana Carolina Dantas Machado, Ming Guo, Jared M. Sagendorf, Zhan Zhou, Longying Jiang, Xiaojuan Chen, Daichao Wu, Lingzhi Qu, Zhuchu Chen, Lin Chen, Remo Rohs, and Yongheng Chen (25 July 2017). "Structure of the forkhead domain of FOXA2 bound to a complete DNA consensus site". Biochemistry. 56 (29): 3745–3753. doi:10.1021/acs.biochem.7b00211. PMID 28644006. Retrieved 28 August 2020.
  3. Eiji Yoshihara (18 August 2020). "TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis". Antioxidants. 9 (8): 765–84. doi:10.3390/antiox9080765. PMID 32824669 Check |pmid= value (help). Retrieved 5 September 2020.

External links