P53 response element gene transcriptions
Associate Editor(s)-in-Chief: Henry A. Hoff
"The p53 REs are defined by two closely spaced decameric half-sites [consensus sequence: 5′-(RRRCWWGYYY)n(RRRCWWGYYY)-3′; R = A,G; W = A,T; Y = C,T; n = spacer of length 0–20 base pairs (bp)], and hundreds of them have been validated in human and mouse (1)."[1]
"According to EMSA binding experiments, all core sequences CAGG and CGTG and their palindrome sequences CCTG and CACG can be bound by p63 [18]. TAACATGTTT or TAACTTGTAT or TAACCTGTAT or TAACGTGTAT bound to p63 much more strongly than AGGCATGATG or GAGCTTGATT or GACCCTGACC or CCCCGTGCAC in EMSA experiments [21]. Therefore, p63 prefers AT-rich flanking sequences rather than general GC rich in purine (Pu) and pyrimidine (Py) bases that comprise the flanking sequence for p53 or p73 [...] [21]."[2]
Human genes
Consensus sequences
An apparent consensus sequence for the p53RE is (A/G)(A/G)(A/G)C(A/T)(A/T)G(C/T)(C/T)(C/T).
Samplings
Copying an apparent consensus sequence for the p53RE (GGGCATGCCT) and putting it in "⌘F" finds none located between ZSCAN22 and none between ZNF497 and A1BG as can be found by the computer programs.
Copying an apparent core consensus sequence for the p53RE (CAGG) and putting it in "⌘F" finds three located between ZSCAN22 and 49 between ZNF497 and A1BG as can be found by the computer programs.
Copying an apparent core consensus sequence for the p53RE (CGTG) and putting it in "⌘F" finds 27 located between ZSCAN22 and eleven between ZNF497 and A1BG as can be found by the computer programs.
Copying an apparent consensus sequence for the p53RE (TAACATGTTT) and putting it in "⌘F" finds none located between ZSCAN22 and none between ZNF497 and A1BG as can be found by the computer programs.
Copying an apparent consensus sequence for the p53RE (TAACTTGTAT) and putting it in "⌘F" finds none located between ZSCAN22 and none between ZNF497 and A1BG as can be found by the computer programs.
Copying an apparent consensus sequence for the p53RE (TAACCTGTAT) and putting it in "⌘F" finds none located between ZSCAN22 and none between ZNF497 and A1BG as can be found by the computer programs.
Copying an apparent consensus sequence for the p53RE (TAACGTGTAT) and putting it in "⌘F" finds none located between ZSCAN22 and none between ZNF497 and A1BG as can be found by the computer programs.
Copying an apparent consensus sequence for the p53RE (AGGCATGATG) and putting it in "⌘F" finds none located between ZSCAN22 and none between ZNF497 and A1BG as can be found by the computer programs.
Copying an apparent consensus sequence for the p53RE (GAGCTTGATT) and putting it in "⌘F" finds none located between ZSCAN22 and none between ZNF497 and A1BG as can be found by the computer programs.
Copying an apparent consensus sequence for the p53RE (GACCCTGACC) and putting it in "⌘F" finds none located between ZSCAN22 and none between ZNF497 and A1BG as can be found by the computer programs.
Copying an apparent consensus sequence for the p53RE (CCCCGTGCAC) and putting it in "⌘F" finds none located between ZSCAN22 and none between ZNF497 and A1BG as can be found by the computer programs.
See also
References
- ↑ Xiaojun Zhang, Ana Carolina Dantas Machado, Yuan Ding, Yongheng Chen, Yan Lu, Yankun Duan, Kenneth W. Tham, Lin Chen, Remo Rohs, Peter Z. Qin (1 February 2014). "Conformations of p53 response elements in solution deduced using site-directed spin labeling and Monte Carlo sampling". Nucleic Acids Research. 42 (4): 2789–2797. doi:10.1093/nar/gkt1219. PMID 24293651. Retrieved 28 August 2020.
- ↑ Bi-He Cai, Chung-Faye Chao, Hsiang-Chi Huang, Hsueh-Yi Lee, Reiji Kannagi, and Jang-Yi Chen (27 July 2019). "Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation". International Journal of Molecular Sciences. 20 (15): 3681–3700. doi:10.3390/ijms20153681. Retrieved 5 October 2020.