GGC triplet gene transcriptions
Associate Editor(s)-in-Chief: Henry A. Hoff
"The transcription factors Uga3, Dal81 and Leu3 belong to the class III family (Zn(II)2Cys6 proteins), and they recognize highly related sequences rich in GGC triplets [15]."[1]
Human genes
Gene expressions
Interactions
Consensus sequences
"Known consensus string Type of motifs LEU3 CCGNNNNCGG or GGCNNNNGCC Gapped motif".[2]
"MEME analysis identified phylogenetically conserved CCGN4CGG motifs in promoters of several [branched-chain amino acid] BCAA biosynthetic genes"[3]
"The promoters of the BCAA biosynthetic leuA and the iron-regulatory hapX genes contain an evolutionary conserved CCGN4CGG motif."[3]
"LeuB is able to bind to the CCGN4CGG motifs in the promoters of gdhA, hapX and leuA."[3]
Binding site for
Enhancer activity
Promoter occurrences
"The regulatory regions of the UGA4 and UGA1 genes contain a UASGABA element (5'- AAAAACCGCCGGCGGCAAT-3') target of Uga3 and Dal81 factors. Within this element there is a consensus site for Leu3 [8, 10, 11, 35]. In contrast, UGA2 has a consensus site for Uga3 (5'-SGCGGNWTT-3') but not a defined UASGABA element or a Leu3 putative site."[1]
Hypotheses
- A1BG has no regulatory elements in either promoter.
- A1BG is not transcribed by a regulatory element.
- No regulatory element participates in the transcription of A1BG.
Samplings
Copying a responsive elements consensus sequence AAAAAAAA and putting the sequence in "⌘F" finds none between ZNF497 and A1BG or none between ZSCAN22 and A1BG as can be found by the computer programs.
For the Basic programs testing consensus sequence AAAAAAAA (starting with SuccessablesAAA.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:
- negative strand, negative direction, looking for AAAAAAAA, 0.
- positive strand, negative direction, looking for AAAAAAAA, 0.
- positive strand, positive direction, looking for AAAAAAAA, 0.
- negative strand, positive direction, looking for AAAAAAAA, 0.
- complement, negative strand, negative direction, looking for TTTTTTTT, 0.
- complement, positive strand, negative direction, looking for TTTTTTTT, 0.
- complement, positive strand, positive direction, looking for TTTTTTTT, 0.
- complement, negative strand, positive direction, looking for TTTTTTTT, 0.
- inverse complement, negative strand, negative direction, looking for TTTTTTTT, 0.
- inverse complement, positive strand, negative direction, looking for TTTTTTTT, 0.
- inverse complement, positive strand, positive direction, looking for TTTTTTTT, 0.
- inverse complement, negative strand, positive direction, looking for TTTTTTTT, 0.
- inverse negative strand, negative direction, looking for AAAAAAAA, 0.
- inverse positive strand, negative direction, looking for AAAAAAAA, 0.
- inverse positive strand, positive direction, looking for AAAAAAAA, 0.
- inverse negative strand, positive direction, looking for AAAAAAAA, 0.
AAA UTRs
AAA core promoters
AAA proximal promoters
AAA distal promoters
Acknowledgements
The content on this page was first contributed by: Henry A. Hoff.
See also
- A1BG gene transcription core promoters
- A1BG gene transcriptions
- A1BG regulatory elements and regions
- A1BG response element gene transcriptions
- A1BG response element negative results
- A1BG response element positive results
- ABA responsive elements
- Activating protein 2
- AhR responsive element
- Antioxidant-electrophile responsive elements
- B-boxes
- B recognition elements
- CadC binding domains
- Calcineurin-responsive transcription factors
- Carbohydrate response elements
- Complex locus A1BG and ZNF497
- Dioxin-responsive elements
- GC boxes
- GCC boxes
- Hex sequences
- Initiator elements
- Krüppel-like factors
- Metal responsive elements
- N-boxes
- ORESARA1
- p53 response elements
- Polycomb response elements
- Glucose transporter gene repressor
- variant RORE motif
- Sp1
- Unfolded protein response element
- Upstream stimulating factors
References
- ↑ 1.0 1.1 Marcos Palavecino-Ruiz, Mariana Bermudez-Moretti and Susana Correa-Garcia (12 October 2017). "Unravelling the transcriptional regulation of Saccharomyces cerevisiae UGA genes: the dual role of transcription factor Leu3" (PDF). Microbiology. 163: 1692–1701. doi:10.1099/mic.0.000560. Retrieved 20 April 2021.
- ↑ Uyyala Srinivasulu Reddy, Michael Arock, A.V. Reddy (20 April 2020). "Discovering of gapped motifs using particle swarm optimisation". International Journal of Computational Intelligence in Bioinformatics and Systems Biology. 2 (1): 1–21. doi:10.1504/IJCIBSB.2020.106858. Retrieved 20 April 2021.
- ↑ 3.0 3.1 3.2 Nanbiao Long, Thomas Orasch, Shizhu Zhang, Lu Gao, Xiaoling Xu, Peter Hortschansky, Jing Ye, Fenli Zhang, Kai Xu, Fabio Gsaller, Maria Straßburger, Ulrike Binder, Thorsten Heinekamp, Axel A. Brakhage, Hubertus Haas, Ling Lu (26 October 2018). "The Zn2Cys6-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus". PLOS Genetics. 14 (10): e1007762. doi:10.1371/journal.pgen.1007762. Retrieved 20 April 2021.