POU2F1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.

Interactions

POU2F1 has been shown to interact with:

• EPRS,
• Glucocorticoid receptor,
• Glyceraldehyde 3-phosphate dehydrogenase,
• Host cell factor C1,
• Ku80,
• MNAT1
• NPAT,
• Nuclear receptor co-repressor 2,
• POU2AF1,
• RELA,
• Retinoid X receptor alpha,
• SNAPC4,
• Sp1 transcription factor, and
• TATA binding protein.

See also

• Octamer transcription factor

Further reading

• Hsieh CL, Sturm R, Herr W, Francke U (1990). "The gene for the ubiquitous octamer-binding protein Oct–1 is on human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on mouse chromosome 1". Genomics. 6 (4): 666–72. doi:10.1016/0888-7543(90)90502-L. PMID 2341156.
• Sturm RA, Das G, Herr W (1989). "The ubiquitous octamer-binding protein Oct–1 contains a POU domain with a homeo box subdomain". Genes Dev. 2 (12A): 1582–99. doi:10.1101/gad.2.12a.1582. PMID 2905684.
• Nakshatri H, Nakshatri P, Currie RA (1995). "Interaction of Oct–1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter". J. Biol. Chem. 270 (33): 19613–23. doi:10.1074/jbc.270.33.19613. PMID 7642649.
• Cox M, van Tilborg PJ, de Laat W, Boelens R, van Leeuwen HC, van der Vliet PC, Kaptein R (1995). "Solution structure of the Oct–1 POU homeodomain determined by NMR and restrained molecular dynamics". J. Biomol. NMR. 6 (1): 23–32. doi:10.1007/BF00417488. PMID 7663141.
• Jeang KT, Chun R, Lin NH, Gatignol A, Glabe CG, Fan H (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". J. Virol. 67 (10): 6224–33. PMC 238044. PMID 7690421.
• Zwilling S, König H, Wirth T (1995). "High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors". EMBO J. 14 (6): 1198–208. PMC 398197. PMID 7720710.
• Sturm RA, Eyre HJ, Baker E, Sutherland GR (1995). "The human OTF1 locus which overlaps the CD3Z gene is located at 1q22→q23". Cytogenet. Cell Genet. 68 (3–4): 231–2. doi:10.1159/000133919. PMID 7842742.
• Klemm JD, Rould MA, Aurora R, Herr W, Pabo CO (1994). "Crystal structure of the Oct–1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules". Cell. 77 (1): 21–32. doi:10.1016/0092-8674(94)90231-3. PMID 8156594.
• Zwilling S, Annweiler A, Wirth T (1994). "The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP". Nucleic Acids Res. 22 (9): 1655–62. doi:10.1093/nar/22.9.1655. PMC 308045. PMID 8202368.
• Kristie TM, Sharp PA (1993). "Purification of the cellular C1 factor required for the stable recognition of the Oct–1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)". J. Biol. Chem. 268 (9): 6525–34. PMID 8454622.
• Assa-Munt N, Mortishire-Smith RJ, Aurora R, Herr W, Wright PE (1993). "The solution structure of the Oct–1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain". Cell. 73 (1): 193–205. doi:10.1016/0092-8674(93)90171-L. PMID 8462099.
• Dekker N, Cox M, Boelens R, Verrijzer CP, van der Vliet PC, Kaptein R (1993). "Solution structure of the POU-specific DNA-binding domain of Oct–1". Nature. 362 (6423): 852–5. doi:10.1038/362852a0. PMID 8479524.
• Ström AC, Forsberg M, Lillhager P, Westin G (1996). "The transcription factors Sp1 and Oct–1 interact physically to regulate human U2 snRNA gene expression". Nucleic Acids Res. 24 (11): 1981–6. doi:10.1093/nar/24.11.1981. PMC 145891. PMID 8668525.
• Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG (1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors". J. Biol. Chem. 272 (47): 29852–8. doi:10.1074/jbc.272.47.29852. PMID 9368058.
• Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (1998). "The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct–1". Mol. Cell. Biol. 18 (1): 368–77. doi:10.1128/mcb.18.1.368. PMC 121507. PMID 9418884.
• Nie J, Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T (1998). "Interaction of Oct–1 and automodification domain of poly(ADP-ribose) synthetase". FEBS Lett. 424 (1–2): 27–32. doi:10.1016/S0014-5793(98)00131-8. PMID 9537509.
• Préfontaine GG, Lemieux ME, Giffin W, Schild-Poulter C, Pope L, LaCasse E, Walker P, Haché RJ (1998). "Recruitment of Octamer Transcription Factors to DNA by Glucocorticoid Receptor". Mol. Cell. Biol. 18 (6): 3416–30. PMC 108923. PMID 9584182.
• La Boissière S, Hughes T, O'Hare P (1999). "HCF-dependent nuclear import of VP16". EMBO J. 18 (2): 480–9. doi:10.1093/emboj/18.2.480. PMC 1171141. PMID 9889203.

External links

• POU2F1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)