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{{Infobox gene}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
'''Retinoic acid receptor gamma''' ('''RXR-gamma'''), also known as '''NR2B3''' (nuclear receptor subfamily 2, group B, member 3) is a [[nuclear receptor]] that in humans is encoded by the ''RXRG'' [[gene]].<ref name="pmid8034312">{{cite journal | vauthors = Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM | title = Chromosomal localization of the human retinoid X receptors | journal = Genomics | volume = 20 | issue = 3 | pages = 397–403 | date = April 1994 | pmid = 8034312 | doi = 10.1006/geno.1994.1193 }}</ref><ref name="entrez" />
{{GNF_Protein_box
| image = PBB_Protein_RXRG_image.jpg
| image_source = Crystallographic structure of the [[DNA-binding domain]] of the Retinoid X receptor, gamma.  [[Protein_Data_Bank|PDB]] rendering based on 1by4.
| PDB = {{PDB2|1by4}}, {{PDB2|1dsz}}, {{PDB2|1r0n}}, {{PDB2|1rxr}}, {{PDB2|2gl8}}, {{PDB2|2nll}}
| Name = Retinoid X receptor, gamma
| HGNCid = 10479
| Symbol = RXRG
| AltSymbols =; NR2B3; RXRC
| OMIM = 180247
| ECnumber = 
| Homologene = 21373
| MGIid = 98216
| GeneAtlas_image1 = PBB_GE_RXRG_205954_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0004886 |text = retinoid-X receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016439 |text = tRNA-pseudouridine synthase activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6258
    | Hs_Ensembl = ENSG00000143171
    | Hs_RefseqProtein = NP_001009598
    | Hs_RefseqmRNA = NM_001009598
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 163636778
    | Hs_GenLoc_end = 163681057
    | Hs_Uniprot = P48443
    | Mm_EntrezGene = 20183
    | Mm_Ensembl = ENSMUSG00000015843
    | Mm_RefseqmRNA = NM_009107
    | Mm_RefseqProtein = NP_033133
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 169435059
    | Mm_GenLoc_end = 169476298
    | Mm_Uniprot = Q3V193
  }}
}}
'''Retinoic acid receptor gamma''' ('''RXR-gamma'''), also known as '''NR2B3''' (nuclear receptor subfamily 2, group B, member 3) is a [[nuclear receptor]] encoded by the {{gene|RXRG}} gene.<ref name="entrez" />


This gene encodes a member of the [[retinoid X receptor]] (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of [[retinoic acid]] (RA). This receptor forms homodimers with the [[retinoic acid receptor|retinoic acid]], [[thyroid hormone receptor|thyroid hormone]], and [[calcitriol receptor|vitamin D receptors]], increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. [[Alternative splicing|Alternate transcriptional splice]] variants, encoding different [[protein isoform|isoforms]], have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: RXRG retinoid X receptor, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6258| accessdate = }}</ref>
== Function ==


==See also==
This gene encodes a member of the [[retinoid X receptor]] (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of [[retinoic acid]] (RA). This receptor forms heterodimers with the [[retinoic acid receptor|retinoic acid]], [[thyroid hormone receptor|thyroid hormone]], and [[calcitriol receptor|vitamin D receptors]], increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. [[Alternative splicing|Alternate transcriptional splice]] variants, encoding different [[protein isoform|isoforms]], have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: RXRG retinoid X receptor, gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6258| accessdate = }}</ref>
 
== See also ==
* [[Retinoid X receptor]]
* [[Retinoid X receptor]]


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
Retinoid X receptor gamma has been shown to [[Protein-protein interaction|interact]] with [[ITGB3BP]].<ref name=pmid11713274>{{cite journal | vauthors = Li D, Wang F, Samuels HH | title = Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation | journal = Mol. Cell. Biol. | volume = 21 | issue = 24 | pages = 8371–84 | date = Dec 2001 | pmid = 11713274 | pmc = 100002 | doi = 10.1128/MCB.21.24.8371-8384.2001 }}</ref>
{{refbegin | 2}}
 
{{PBB_Further_reading
== References ==
| citations =  
{{Reflist}}
*{{cite journal  | author=Szanto A, Narkar V, Shen Q, ''et al.'' |title=Retinoid X receptors: X-ploring their (patho)physiological functions. |journal=Cell Death Differ. |volume=11 Suppl 2 |issue= |pages= S126-43 |year= 2005 |pmid= 15608692 |doi= 10.1038/sj.cdd.4401533 }}
{{Clear}}
*{{cite journal  | author=Leid M, Kastner P, Lyons R, ''et al.'' |title=Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. |journal=Cell |volume=68 |issue= 2 |pages= 377-95 |year= 1992 |pmid= 1310259 |doi= }}
 
*{{cite journal | author=Mangelsdorf DJ, Borgmeyer U, Heyman RA, ''et al.'' |title=Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. |journal=Genes Dev. |volume=6 |issue= 3 |pages= 329-44 |year= 1992 |pmid= 1312497 |doi= }}
== Further reading ==
*{{cite journal | author=Nagata T, Weiss EH, Abe K, ''et al.'' |title=Physical mapping of the retinoid X receptor B gene in mouse and human. |journal=Immunogenetics |volume=41 |issue= 2-3 |pages= 83-90 |year= 1995 |pmid= 7806300 |doi= }}
{{Refbegin | 2}}
*{{cite journal | author=Almasan A, Mangelsdorf DJ, Ong ES, ''et al.'' |title=Chromosomal localization of the human retinoid X receptors. |journal=Genomics |volume=20 |issue= 3 |pages= 397-403 |year= 1994 |pmid= 8034312 |doi= 10.1006/geno.1994.1193 }}
* {{cite journal | vauthors = Szanto A, Narkar V, Shen Q, Uray IP, Davies PJ, Nagy L | title = Retinoid X receptors: X-ploring their (patho)physiological functions. | journal = Cell Death Differ. | volume = 11 Suppl 2 | issue = | pages = S126–43 | year = 2005 | pmid = 15608692 | doi = 10.1038/sj.cdd.4401533 }}
*{{cite journal | author=Muscat GE, Mynett-Johnson L, Dowhan D, ''et al.'' |title=Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors. |journal=Nucleic Acids Res. |volume=22 |issue= 4 |pages= 583-91 |year= 1994 |pmid= 8127707 |doi= }}
* {{cite journal | vauthors = Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Garnier JM, Mader S | title = Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. | journal = Cell | volume = 68 | issue = 2 | pages = 377–95 | year = 1992 | pmid = 1310259 | doi = 10.1016/0092-8674(92)90478-U }}
*{{cite journal | author=Kamei Y, Xu L, Heinzel T, ''et al.'' |title=A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. |journal=Cell |volume=85 |issue= 3 |pages= 403-14 |year= 1996 |pmid= 8616895 |doi= }}
* {{cite journal | vauthors = Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A, Evans RM | title = Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. | journal = Genes Dev. | volume = 6 | issue = 3 | pages = 329–44 | year = 1992 | pmid = 1312497 | doi = 10.1101/gad.6.3.329 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Nagata T, Weiss EH, Abe K, Kitagawa K, Ando A, Yara-Kikuti Y, Seldin MF, Ozato K, Inoko H, Taketo M | title = Physical mapping of the retinoid X receptor B gene in mouse and human. | journal = Immunogenetics | volume = 41 | issue = 2–3 | pages = 83–90 | year = 1995 | pmid = 7806300 | doi = 10.1007/BF00182317 }}
*{{cite journal | author=Sanno N, Sugawara A, Teramoto A, ''et al.'' |title=Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas. |journal=Neuroendocrinology |volume=65 |issue= 4 |pages= 299-306 |year= 1997 |pmid= 9143002 |doi= }}
* {{cite journal | vauthors = Muscat GE, Mynett-Johnson L, Dowhan D, Downes M, Griggs R | title = Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors | journal = Nucleic Acids Res. | volume = 22 | issue = 4 | pages = 583–91 | year = 1994 | pmid = 8127707 | pmc = 307847 | doi = 10.1093/nar/22.4.583 }}
*{{cite journal | author=Reichrath J, Mittmann M, Kamradt J, Müller SM |title=Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation. |journal=Histochem. J. |volume=29 |issue= 2 |pages= 127-33 |year= 1997 |pmid= 9147069 |doi= }}
* {{cite journal | vauthors = Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Heyman RA, Rose DW, Glass CK, Rosenfeld MG | title = A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors | journal = Cell | volume = 85 | issue = 3 | pages = 403–14 | year = 1996 | pmid = 8616895 | doi = 10.1016/S0092-8674(00)81118-6 }}
*{{cite journal | author=Xu XC, Sozzi G, Lee JS, ''et al.'' |title=Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development. |journal=J. Natl. Cancer Inst. |volume=89 |issue= 9 |pages= 624-9 |year= 1997 |pmid= 9150186 |doi= }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Yusta B, Alarid ET, Gordon DF, ''et al.'' |title=The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells. |journal=Endocrinology |volume=139 |issue= 11 |pages= 4476-82 |year= 1998 |pmid= 9794455 |doi= }}
* {{cite journal | vauthors = Sanno N, Sugawara A, Teramoto A, Abe Y, Yen PM, Chin WW, Osamura RY | title = Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas | journal = Neuroendocrinology | volume = 65 | issue = 4 | pages = 299–306 | year = 1997 | pmid = 9143002 | doi = 10.1159/000127188 }}
*{{cite journal | author=Ito K, Suzuki T, Moriya T, ''et al.'' |title=Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17 beta-hydroxysteroid dehydrogenase. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 6 |pages= 2721-7 |year= 2001 |pmid= 11397877 |doi= }}
* {{cite journal | vauthors = Reichrath J, Mittmann M, Kamradt J, Müller SM | title = Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation | journal = Histochem. J. | volume = 29 | issue = 2 | pages = 127–33 | year = 1997 | pmid = 9147069 | doi = 10.1023/A:1026481205135 }}
*{{cite journal | author=Kim SW, Kim HJ, Jung DJ, ''et al.'' |title=Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins. |journal=Oncogene |volume=20 |issue= 45 |pages= 6638-42 |year= 2001 |pmid= 11641790 |doi= 10.1038/sj.onc.1204695 }}
* {{cite journal | vauthors = Xu XC, Sozzi G, Lee JS, Lee JJ, Pastorino U, Pilotti S, Kurie JM, Hong WK, Lotan R | title = Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development | journal = J. Natl. Cancer Inst. | volume = 89 | issue = 9 | pages = 624–9 | year = 1997 | pmid = 9150186 | doi = 10.1093/jnci/89.9.624 }}
*{{cite journal | author=Brabender J, Danenberg KD, Metzger R, ''et al.'' |title=The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer. |journal=Clin. Cancer Res. |volume=8 |issue= 2 |pages= 438-43 |year= 2002 |pmid= 11839661 |doi=  }}
* {{cite journal | vauthors = Yusta B, Alarid ET, Gordon DF, Ridgway EC, Mellon PL | title = The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells | journal = Endocrinology | volume = 139 | issue = 11 | pages = 4476–82 | year = 1998 | pmid = 9794455 | doi = 10.1210/en.139.11.4476 }}
*{{cite journal | author=Wansa KD, Harris JM, Muscat GE |title=The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment. |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 33001-11 |year= 2002 |pmid= 12082103 |doi= 10.1074/jbc.M203572200 }}
* {{cite journal | vauthors = Ito K, Suzuki T, Moriya T, Utsunomiya H, Sugawara A, Konno R, Sato S, Sasano H | title = Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17 beta-hydroxysteroid dehydrogenase | journal = J. Clin. Endocrinol. Metab. | volume = 86 | issue = 6 | pages = 2721–7 | year = 2001 | pmid = 11397877 | doi = 10.1210/jc.86.6.2721 }}
*{{cite journal | author=Wang Q, Fujii H, Knipp GT |title=Expression of PPAR and RXR isoforms in the developing rat and human term placentas. |journal=Placenta |volume=23 |issue= 8-9 |pages= 661-71 |year= 2003 |pmid= 12361685 |doi= }}
* {{cite journal | vauthors = Kim SW, Kim HJ, Jung DJ, Lee SK, Kim YS, Kim JH, Kim TS, Lee JW | title = Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins | journal = Oncogene | volume = 20 | issue = 45 | pages = 6638–42 | year = 2001 | pmid = 11641790 | doi = 10.1038/sj.onc.1204695 }}
*{{cite journal | author=Kimura Y, Suzuki T, Kaneko C, ''et al.'' |title=Retinoid receptors in the developing human lung. |journal=Clin. Sci. |volume=103 |issue= 6 |pages= 613-21 |year= 2003 |pmid= 12444914 |doi= 10.1042/ }}
* {{cite journal | vauthors = Brabender J, Danenberg KD, Metzger R, Schneider PM, Lord RV, Groshen S, Tsao-Wei DD, Park J, Salonga D, Hölscher AH, Danenberg PV | title = The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer | journal = Clin. Cancer Res. | volume = 8 | issue = 2 | pages = 438–43 | year = 2002 | pmid = 11839661 | doi =  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Wansa KD, Harris JM, Muscat GE | title = The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment | journal = J. Biol. Chem. | volume = 277 | issue = 36 | pages = 33001–11 | year = 2002 | pmid = 12082103 | doi = 10.1074/jbc.M203572200 }}
*{{cite journal  | author=Alfaro JM, Fraile B, Lobo MV, ''et al.'' |title=Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate. |journal=J. Androl. |volume=24 |issue= 1 |pages= 113-9 |year= 2003 |pmid= 12514092 |doi=  }}
* {{cite journal | vauthors = Wang Q, Fujii H, Knipp GT | title = Expression of PPAR and RXR isoforms in the developing rat and human term placentas | journal = Placenta | volume = 23 | issue = 8–9 | pages = 661–71 | year = 2003 | pmid = 12361685 | doi = 10.1053/plac.2002.0855 }}
}}
* {{cite journal | vauthors = Kimura Y, Suzuki T, Kaneko C, Darnel AD, Moriya T, Suzuki S, Handa M, Ebina M, Nukiwa T, Sasano H | title = Retinoid receptors in the developing human lung | journal = Clin. Sci. | volume = 103 | issue = 6 | pages = 613–21 | year = 2003 | pmid = 12444914 | doi = }}
{{refend}}
* {{cite journal | vauthors = Alfaro JM, Fraile B, Lobo MV, Royuela M, Paniagua R, Arenas MI | title = Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate | journal = J. Androl. | volume = 24 | issue = 1 | pages = 113–9 | year = 2003 | pmid = 12514092 | doi =  }}
{{Refend}}


{{NLM content}}
{{NLM content}}
{{protein-stub}}
{{PDB Gallery|geneid=6258}}
{{Transcription factors}}
{{Transcription factors|g2}}
{{Retinoid receptor modulators}}
 
[[Category:Intracellular receptors]]
[[Category:Intracellular receptors]]
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{Gene-1-stub}}

Latest revision as of 16:57, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

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n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Retinoic acid receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor that in humans is encoded by the RXRG gene.[1][2]

Function

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

See also

Interactions

Retinoid X receptor gamma has been shown to interact with ITGB3BP.[3]

References

  1. ↑ Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM (April 1994). "Chromosomal localization of the human retinoid X receptors". Genomics. 20 (3): 397–403. doi:10.1006/geno.1994.1193. PMID 8034312.
  2. ↑ 2.0 2.1 "Entrez Gene: RXRG retinoid X receptor, gamma".
  3. ↑ Li D, Wang F, Samuels HH (Dec 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. PMC 100002. PMID 11713274.

Further reading

  • Szanto A, Narkar V, Shen Q, Uray IP, Davies PJ, Nagy L (2005). "Retinoid X receptors: X-ploring their (patho)physiological functions". Cell Death Differ. 11 Suppl 2: S126–43. doi:10.1038/sj.cdd.4401533. PMID 15608692.
  • Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Garnier JM, Mader S (1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently". Cell. 68 (2): 377–95. doi:10.1016/0092-8674(92)90478-U. PMID 1310259.
  • Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A, Evans RM (1992). "Characterization of three RXR genes that mediate the action of 9-cis retinoic acid". Genes Dev. 6 (3): 329–44. doi:10.1101/gad.6.3.329. PMID 1312497.
  • Nagata T, Weiss EH, Abe K, Kitagawa K, Ando A, Yara-Kikuti Y, Seldin MF, Ozato K, Inoko H, Taketo M (1995). "Physical mapping of the retinoid X receptor B gene in mouse and human". Immunogenetics. 41 (2–3): 83–90. doi:10.1007/BF00182317. PMID 7806300.
  • Muscat GE, Mynett-Johnson L, Dowhan D, Downes M, Griggs R (1994). "Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors". Nucleic Acids Res. 22 (4): 583–91. doi:10.1093/nar/22.4.583. PMC 307847. PMID 8127707.
  • Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Heyman RA, Rose DW, Glass CK, Rosenfeld MG (1996). "A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors". Cell. 85 (3): 403–14. doi:10.1016/S0092-8674(00)81118-6. PMID 8616895.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Sanno N, Sugawara A, Teramoto A, Abe Y, Yen PM, Chin WW, Osamura RY (1997). "Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas". Neuroendocrinology. 65 (4): 299–306. doi:10.1159/000127188. PMID 9143002.
  • Reichrath J, Mittmann M, Kamradt J, Müller SM (1997). "Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation". Histochem. J. 29 (2): 127–33. doi:10.1023/A:1026481205135. PMID 9147069.
  • Xu XC, Sozzi G, Lee JS, Lee JJ, Pastorino U, Pilotti S, Kurie JM, Hong WK, Lotan R (1997). "Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development". J. Natl. Cancer Inst. 89 (9): 624–9. doi:10.1093/jnci/89.9.624. PMID 9150186.
  • Yusta B, Alarid ET, Gordon DF, Ridgway EC, Mellon PL (1998). "The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells". Endocrinology. 139 (11): 4476–82. doi:10.1210/en.139.11.4476. PMID 9794455.
  • Ito K, Suzuki T, Moriya T, Utsunomiya H, Sugawara A, Konno R, Sato S, Sasano H (2001). "Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17 beta-hydroxysteroid dehydrogenase". J. Clin. Endocrinol. Metab. 86 (6): 2721–7. doi:10.1210/jc.86.6.2721. PMID 11397877.
  • Kim SW, Kim HJ, Jung DJ, Lee SK, Kim YS, Kim JH, Kim TS, Lee JW (2001). "Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins". Oncogene. 20 (45): 6638–42. doi:10.1038/sj.onc.1204695. PMID 11641790.
  • Brabender J, Danenberg KD, Metzger R, Schneider PM, Lord RV, Groshen S, Tsao-Wei DD, Park J, Salonga D, Hölscher AH, Danenberg PV (2002). "The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer". Clin. Cancer Res. 8 (2): 438–43. PMID 11839661.
  • Wansa KD, Harris JM, Muscat GE (2002). "The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment". J. Biol. Chem. 277 (36): 33001–11. doi:10.1074/jbc.M203572200. PMID 12082103.
  • Wang Q, Fujii H, Knipp GT (2003). "Expression of PPAR and RXR isoforms in the developing rat and human term placentas". Placenta. 23 (8–9): 661–71. doi:10.1053/plac.2002.0855. PMID 12361685.
  • Kimura Y, Suzuki T, Kaneko C, Darnel AD, Moriya T, Suzuki S, Handa M, Ebina M, Nukiwa T, Sasano H (2003). "Retinoid receptors in the developing human lung". Clin. Sci. 103 (6): 613–21. PMID 12444914.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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