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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Hox-D9''' is a [[protein]] that in humans is encoded by the ''HOXD9'' [[gene]].<ref name="pmid1973146">{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 | date = Aug 1990 | pmid = 1973146 | pmc =  | doi = 10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 | date = Dec 1992 | pmid = 1358459 | pmc = | doi = 10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXD9 homeobox D9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3235| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_HOXD9_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1puf.
| PDB = {{PDB2|1puf}}
| Name = Homeobox D9
| HGNCid = 5140
| Symbol = HOXD9
| AltSymbols =; HOX4; HOX4C; Hox-4.3; Hox-5.2
| OMIM = 142982
| ECnumber = 
| Homologene = 8409
| MGIid = 96210
| GeneAtlas_image1 = PBB_GE_HOXD9_205604_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3235
    | Hs_Ensembl = ENSG00000128709
    | Hs_RefseqProtein = NP_055028
    | Hs_RefseqmRNA = NM_014213
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 176695334
    | Hs_GenLoc_end = 176697770
    | Hs_Uniprot = P28356
    | Mm_EntrezGene = 15438
    | Mm_Ensembl = ENSMUSG00000043342
    | Mm_RefseqmRNA = NM_013555
    | Mm_RefseqProtein = NP_038583
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 74498600
    | Mm_GenLoc_end = 74501047
    | Mm_Uniprot = Q3UMQ3
  }}
}}
'''Homeobox D9''', also known as '''HOXD9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXD9 homeobox D9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3235| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: HOXD9 homeobox D9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3235| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Homeobox]]
* [[Homeobox]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | vauthors = Zappavigna V, Renucci A, Izpisúa-Belmonte JC, Urier G, Peschle C, Duboule D | title = HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities | journal = EMBO J. | volume = 10 | issue = 13 | pages = 4177–87 | year = 1992 | pmid = 1756725 | pmc = 453170 | doi =  }}
| citations =
*{{cite journal | vauthors = Oliver G, Sidell N, Fiske W, Heinzmann C, Mohandas T, Sparkes RS, De Robertis EM | title = Complementary homeo protein gradients in developing limb buds | journal = Genes Dev. | volume = 3 | issue = 5 | pages = 641–50 | year = 1989 | pmid = 2568311 | doi = 10.1101/gad.3.5.641 }}
*{{cite journal  | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
*{{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Res. | volume = 17 | issue = 24 | pages = 10385–402 | year = 1990 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
*{{cite journal | author=Zappavigna V, Renucci A, Izpisúa-Belmonte JC, ''et al.'' |title=HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. |journal=EMBO J. |volume=10 |issue= 13 |pages= 4177-87 |year= 1992 |pmid= 1756725 |doi=  }}
*{{cite journal | vauthors = Kanzler B, Viallet JP, Le Mouellic H, Boncinelli E, Duboule D, Dhouailly D | title = Differential expression of two different homeobox gene families during mouse tegument morphogenesis | journal = Int. J. Dev. Biol. | volume = 38 | issue = 4 | pages = 633–40 | year = 1995 | pmid = 7779685 | doi =  }}
*{{cite journal  | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
*{{cite journal | vauthors = Zappavigna V, Sartori D, Mavilio F | title = Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain | journal = Genes Dev. | volume = 8 | issue = 6 | pages = 732–44 | year = 1994 | pmid = 7926763 | doi = 10.1101/gad.8.6.732 }}
*{{cite journal | author=Oliver G, Sidell N, Fiske W, ''et al.'' |title=Complementary homeo protein gradients in developing limb buds. |journal=Genes Dev. |volume=3 |issue= 5 |pages= 641-50 |year= 1989 |pmid= 2568311 |doi= }}
*{{cite journal | vauthors = Zappavigna V, Falciola L, Helmer-Citterich M, Mavilio F, Bianchi ME | title = HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation | journal = EMBO J. | volume = 15 | issue = 18 | pages = 4981–91 | year = 1996 | pmid = 8890171 | pmc = 452236 | doi =  }}
*{{cite journal | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi= }}
*{{cite journal | vauthors = Phelan ML, Featherstone MS | title = Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers | journal = J. Biol. Chem. | volume = 272 | issue = 13 | pages = 8635–43 | year = 1997 | pmid = 9079695 | doi = 10.1074/jbc.272.13.8635 }}
*{{cite journal | author=Kanzler B, Viallet JP, Le Mouellic H, ''et al.'' |title=Differential expression of two different homeobox gene families during mouse tegument morphogenesis. |journal=Int. J. Dev. Biol. |volume=38 |issue= 4 |pages= 633-40 |year= 1995 |pmid= 7779685 |doi=  }}
*{{cite journal | vauthors = Del Campo M, Jones MC, Veraksa AN, Curry CJ, Jones KL, Mascarello JT, Ali-Kahn-Catts Z, Drumheller T, McGinnis W | title = Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster | journal = Am. J. Hum. Genet. | volume = 65 | issue = 1 | pages = 104–10 | year = 1999 | pmid = 10364522 | pmc = 1378080 | doi = 10.1086/302467 }}
*{{cite journal | author=Zappavigna V, Sartori D, Mavilio F |title=Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain. |journal=Genes Dev. |volume=8 |issue= 6 |pages= 732-44 |year= 1994 |pmid= 7926763 |doi= }}
*{{cite journal | vauthors = de la Cruz CC, Der-Avakian A, Spyropoulos DD, Tieu DD, Carpenter EM | title = Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development | journal = Dev. Biol. | volume = 216 | issue = 2 | pages = 595–610 | year = 2000 | pmid = 10642795 | doi = 10.1006/dbio.1999.9528}}
*{{cite journal | author=Zappavigna V, Falciola L, Helmer-Citterich M, ''et al.'' |title=HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation. |journal=EMBO J. |volume=15 |issue= 18 |pages= 4981-91 |year= 1996 |pmid= 8890171 |doi=  }}
*{{cite journal | vauthors = Limongi MZ, Pelliccia F, Gaddini L, Rocchi A | title = Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1 | journal = Cytogenet. Cell Genet. | volume = 90 | issue = 1–2 | pages = 151–3 | year = 2000 | pmid = 11060466 | doi = 10.1159/000015651 }}
*{{cite journal | author=Phelan ML, Featherstone MS |title=Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8635-43 |year= 1997 |pmid= 9079695 |doi= }}
*{{cite journal | vauthors = Goodman FR, Majewski F, Collins AL, Scambler PJ | title = A 117-kb Microdeletion Removing HOXD9–HOXD13 and EVX2 Causes Synpolydactyly | journal = Am. J. Hum. Genet. | volume = 70 | issue = 2 | pages = 547–55 | year = 2002 | pmid = 11778160 | pmc = 384929 | doi = 10.1086/338921 }}
*{{cite journal | author=Del Campo M, Jones MC, Veraksa AN, ''et al.'' |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster. |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104-10 |year= 1999 |pmid= 10364522 |doi= }}
*{{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | year = 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }}
*{{cite journal | author=de la Cruz CC, Der-Avakian A, Spyropoulos DD, ''et al.'' |title=Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development. |journal=Dev. Biol. |volume=216 |issue= 2 |pages= 595-610 |year= 2000 |pmid= 10642795 |doi= 10.1006/dbio.1999.9528 }}
*{{cite journal | vauthors = Nguyen NC, Hirose T, Nakazawa M, Kobata T, Nakamura H, Nishioka K, Nakajima T | title = Expression of HOXD9 in fibroblast-like synoviocytes from rheumatoid arthritis patients | journal = Int. J. Mol. Med. | volume = 10 | issue = 1 | pages = 41–8 | year = 2002 | pmid = 12060849 | doi = 10.3892/ijmm.10.1.41 }}
*{{cite journal | author=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1-2 |pages= 151-3 |year= 2000 |pmid= 11060466 |doi= }}
*{{cite journal | vauthors = Méchine-Neuville A, Lefebvre O, Bellocq JP, Kedinger M, Simon-Assmann P | title = [Increased expression of HOXA9 gene in Hirschsprung disease] | journal = Gastroenterol. Clin. Biol. | volume = 26 | issue = 12 | pages = 1110–7 | year = 2003 | pmid = 12520199 | doi =  }}
*{{cite journal | author=Goodman FR, Majewski F, Collins AL, Scambler PJ |title=A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly. |journal=Am. J. Hum. Genet. |volume=70 |issue= 2 |pages= 547-55 |year= 2002 |pmid= 11778160 |doi= }}
*{{cite journal | vauthors = Liu DB, Gu ZD, Cao XZ, Liu H, Li JY | title = Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas | journal = World J. Gastroenterol. | volume = 11 | issue = 10 | pages = 1562–6 | year = 2005 | pmid = 15770739 | doi =  10.3748/wjg.v11.i10.1562}}
*{{cite journal | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal | vauthors = Zhao X, Sun M, Zhao J, Leyva JA, Zhu H, Yang W, Zeng X, Ao Y, Liu Q, Liu G, Lo WH, Jabs EW, Amzel LM, Shan X, Zhang X | title = Mutations in HOXD13 Underlie Syndactyly Type V and a Novel Brachydactyly-Syndactyly Syndrome | journal = Am. J. Hum. Genet. | volume = 80 | issue = 2 | pages = 361–71 | year = 2007 | pmid = 17236141 | pmc = 1785357 | doi = 10.1086/511387 }}
*{{cite journal | author=Nguyen NC, Hirose T, Nakazawa M, ''et al.'' |title=Expression of HOXD9 in fibroblast-like synoviocytes from rheumatoid arthritis patients. |journal=Int. J. Mol. Med. |volume=10 |issue= 1 |pages= 41-8 |year= 2002 |pmid= 12060849 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Méchine-Neuville A, Lefebvre O, Bellocq JP, ''et al.'' |title=[Increased expression of HOXA9 gene in Hirschsprung disease] |journal=Gastroenterol. Clin. Biol. |volume=26 |issue= 12 |pages= 1110-7 |year= 2003 |pmid= 12520199 |doi=  }}
*{{cite journal | author=Liu DB, Gu ZD, Cao XZ, ''et al.'' |title=Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas. |journal=World J. Gastroenterol. |volume=11 |issue= 10 |pages= 1562-6 |year= 2005 |pmid= 15770739 |doi=  }}
*{{cite journal | author=Zhao X, Sun M, Zhao J, ''et al.'' |title=Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome. |journal=Am. J. Hum. Genet. |volume=80 |issue= 2 |pages= 361-71 |year= 2007 |pmid= 17236141 |doi= 10.1086/511387 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|HOXD9+protein,+human}}
* {{MeshName|HOXD9+protein,+human}}
{{PDB Gallery|geneid=3235}}
{{Transcription factors|g3}}


{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-2-stub}}

Latest revision as of 14:02, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein Hox-D9 is a protein that in humans is encoded by the HOXD9 gene.[1][2][3]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.[3]

See also

References

  1. ↑ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. ↑ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. ↑ 3.0 3.1 "Entrez Gene: HOXD9 homeobox D9".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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