HOXC8: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS (v470))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Hox-C8''' is a [[protein]] that in humans is encoded by the ''HOXC8'' [[gene]].<ref name="pmid1973146">{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460  | date = August 1990 | pmid = 1973146 | pmc =  | doi = 10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3  | date = December 1992 | pmid = 1358459 | pmc = | doi = 10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXC8 homeobox C8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3224| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Homeobox C8
| HGNCid = 5129
| Symbol = HOXC8
| AltSymbols =; HOX3; HOX3A
| OMIM = 142970
| ECnumber = 
| Homologene = 88803
| MGIid = 96198
| GeneAtlas_image1 = PBB_GE_HOXC8_221350_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030182 |text = neuron differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3224
    | Hs_Ensembl = ENSG00000037965
    | Hs_RefseqProtein = NP_073149
    | Hs_RefseqmRNA = NM_022658
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 52689157
    | Hs_GenLoc_end = 52692814
    | Hs_Uniprot = P31273
    | Mm_EntrezGene = 15426
    | Mm_Ensembl = ENSMUSG00000001657
    | Mm_RefseqmRNA = NM_010466
    | Mm_RefseqProtein = NP_034596
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 102818573
    | Mm_GenLoc_end = 102821404
    | Mm_Uniprot = Q8BNV9
  }}
}}
'''Homeobox C8''', also known as '''HOXC8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXC8 homeobox C8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3224| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene belongs to the [[homeobox]] family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.<ref name="entrez" /> HOXC8 was found to have activity in promoting nerve growth and its expression is dysregulated in patients suffering from [[neurofibromatosis]] type 1.<ref name=" pmid = 24213587 ">{{cite journal | vauthors = Liu Y, Kang D, Li C, Xu G, Tan Y, Wang J | title = Microarray‑based identification of nerve growth‑promoting genes in neurofibromatosis type I | journal = Mol Med Rep | volume = 9 | issue = 1 | pages = 192–6  | date = Jan 2014 | pmid = 24213587 | doi = 10.3892/mmr.2013.1785 | url = http://www.spandidos-publications.com/mmr/9/1/192 }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.<ref name="entrez">{{cite web | title = Entrez Gene: HOXC8 homeobox C8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3224| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Homeobox]]
* [[Homeobox]]


==References==
== Interactions ==
{{reflist|2}}


==Further reading==
HOXC8 has been shown to [[Protein-protein interaction|interact]] with [[Mothers against decapentaplegic homolog 6]]<ref name=pmid10722652>{{cite journal | vauthors = Bai S, Shi X, Yang X, Cao X | title = Smad6 as a transcriptional corepressor | journal = J. Biol. Chem. | volume = 275 | issue = 12 | pages = 8267–70  | date = March 2000 | pmid = 10722652 | doi = 10.1074/jbc.275.12.8267 }}</ref> and [[Mothers against decapentaplegic homolog 1]].<ref name=pmid10224145>{{cite journal | vauthors = Shi X, Yang X, Chen D, Chang Z, Cao X | title = Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling | journal = J. Biol. Chem. | volume = 274 | issue = 19 | pages = 13711–7  | date = May 1999 | pmid = 10224145 | doi = 10.1074/jbc.274.19.13711 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Res. | volume = 17 | issue = 24 | pages = 10385–402 | year = 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
| citations =
* {{cite journal | vauthors = Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A | title = Organization of human class I homeobox genes | journal = Genome | volume = 31 | issue = 2 | pages = 745–56 | year = 1989 | pmid = 2576652 | doi = 10.1139/g89-133 }}
*{{cite journal  | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
* {{cite journal | vauthors = Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH | title = Cognate homeo-box loci mapped on homologous human and mouse chromosomes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 83 | issue = 23 | pages = 9104–8 | year = 1986 | pmid = 2878432 | pmc = 387083 | doi = 10.1073/pnas.83.23.9104 }}
*{{cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
* {{cite journal | vauthors = Simeone A, Mavilio F, Acampora D, Giampaolo A, Faiella A, Zappavigna V, D'Esposito M, Pannese M, Russo G, Boncinelli E | title = Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 84 | issue = 14 | pages = 4914–8 | year = 1987 | pmid = 2885844 | pmc = 305217 | doi = 10.1073/pnas.84.14.4914 }}
*{{cite journal  | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi= }}
* {{cite journal | vauthors = Cannizzaro LA, Croce CM, Griffin CA, Simeone A, Boncinelli E, Huebner K | title = Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13 | journal = Am. J. Hum. Genet. | volume = 41 | issue = 1 | pages = 1–15 | year = 1987 | pmid = 2886047 | pmc = 1684175 | doi =  }}
*{{cite journal | author=Boncinelli E, Acampora D, Pannese M, ''et al.'' |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745-56 |year= 1990 |pmid= 2576652 |doi= }}
* {{cite journal | vauthors = Lawrence HJ, Stage KM, Mathews CH, Detmer K, Scibienski R, MacKenzie M, Migliaccio E, Boncinelli E, Largman C | title = Expression of HOX C homeobox genes in lymphoid cells | journal = Cell Growth Differ. | volume = 4 | issue = 8 | pages = 665–9 | year = 1993 | pmid = 8104467 | doi =  }}
*{{cite journal | author=Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH |title=Cognate homeo-box loci mapped on homologous human and mouse chromosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 9104-8 |year= 1987 |pmid= 2878432 |doi= }}
* {{cite journal | vauthors = Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B | title = Fine mapping of human HOX gene clusters | journal = Cytogenet. Cell Genet. | volume = 73 | issue = 1-2 | pages = 114–5 | year = 1996 | pmid = 8646877 | doi = 10.1159/000134320 }}
*{{cite journal | author=Simeone A, Mavilio F, Acampora D, ''et al.'' |title=Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 14 |pages= 4914-8 |year= 1987 |pmid= 2885844 |doi= }}
* {{cite journal | vauthors = Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B | title = Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines | journal = FEBS Lett. | volume = 415 | issue = 3 | pages = 263–7 | year = 1997 | pmid = 9357979 | doi = 10.1016/S0014-5793(97)01118-6 }}
*{{cite journal | author=Cannizzaro LA, Croce CM, Griffin CA, ''et al.'' |title=Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13. |journal=Am. J. Hum. Genet. |volume=41 |issue= 1 |pages= 1-15 |year= 1987 |pmid= 2886047 |doi=  }}
* {{cite journal | vauthors = Shi X, Yang X, Chen D, Chang Z, Cao X | title = Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling | journal = J. Biol. Chem. | volume = 274 | issue = 19 | pages = 13711–7 | year = 1999 | pmid = 10224145 | doi = 10.1074/jbc.274.19.13711 }}
*{{cite journal | author=Lawrence HJ, Stage KM, Mathews CH, ''et al.'' |title=Expression of HOX C homeobox genes in lymphoid cells. |journal=Cell Growth Differ. |volume=4 |issue= 8 |pages= 665-9 |year= 1993 |pmid= 8104467 |doi=  }}
* {{cite journal | vauthors = Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, Corbo L | title = The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation | journal = J. Biol. Chem. | volume = 275 | issue = 1 | pages = 147–53 | year = 2000 | pmid = 10617598 | doi = 10.1074/jbc.275.1.147 }}
*{{cite journal | author=Apiou F, Flagiello D, Cillo C, ''et al.'' |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114-5 |year= 1996 |pmid= 8646877 |doi= }}
* {{cite journal | vauthors = Bai S, Shi X, Yang X, Cao X | title = Smad6 as a transcriptional corepressor | journal = J. Biol. Chem. | volume = 275 | issue = 12 | pages = 8267–70 | year = 2000 | pmid = 10722652 | doi = 10.1074/jbc.275.12.8267 }}
*{{cite journal | author=Flagiello D, Gibaud A, Dutrillaux B, ''et al.'' |title=Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. |journal=FEBS Lett. |volume=415 |issue= 3 |pages= 263-7 |year= 1997 |pmid= 9357979 |doi= }}
* {{cite journal | vauthors = Wan M, Shi X, Feng X, Cao X | title = Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression | journal = J. Biol. Chem. | volume = 276 | issue = 13 | pages = 10119–25 | year = 2001 | pmid = 11139569 | doi = 10.1074/jbc.M006918200 }}
*{{cite journal | author=Shi X, Yang X, Chen D, ''et al.'' |title=Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13711-7 |year= 1999 |pmid= 10224145 |doi= }}
* {{cite journal | vauthors = Schaefer LK, Wang S, Schaefer TS | title = Functional interaction of Jun and homeodomain proteins | journal = J. Biol. Chem. | volume = 276 | issue = 46 | pages = 43074–82 | year = 2001 | pmid = 11551904 | doi = 10.1074/jbc.M102552200 }}
*{{cite journal | author=Prévôt D, Voeltzel T, Birot AM, ''et al.'' |title=The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 147-53 |year= 2000 |pmid= 10617598 |doi= }}
* {{cite journal | vauthors = Waltregny D, Alami Y, Clausse N, de Leval J, Castronovo V | title = Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation | journal = Prostate | volume = 50 | issue = 3 | pages = 162–9 | year = 2002 | pmid = 11813208 | doi = 10.1002/pros.10045 }}
*{{cite journal | author=Bai S, Shi X, Yang X, Cao X |title=Smad6 as a transcriptional corepressor. |journal=J. Biol. Chem. |volume=275 |issue= 12 |pages= 8267-70 |year= 2000 |pmid= 10722652 |doi= }}
* {{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | year = 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }}
*{{cite journal | author=Wan M, Shi X, Feng X, Cao X |title=Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression. |journal=J. Biol. Chem. |volume=276 |issue= 13 |pages= 10119-25 |year= 2001 |pmid= 11139569 |doi= 10.1074/jbc.M006918200 }}
* {{cite journal | vauthors = Bayarsaihan D, Enkhmandakh B, Makeyev A, Greally JM, Leckman JF, Ruddle FH | title = Homez, a homeobox leucine zipper gene specific to the vertebrate lineage | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 18 | pages = 10358–63 | year = 2003 | pmid = 12925734 | pmc = 193566 | doi = 10.1073/pnas.1834010100 }}
*{{cite journal | author=Schaefer LK, Wang S, Schaefer TS |title=Functional interaction of Jun and homeodomain proteins. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 43074-82 |year= 2001 |pmid= 11551904 |doi= 10.1074/jbc.M102552200 }}
* {{cite journal | vauthors = Luo L, Yang X, Takihara Y, Knoetgen H, Kessel M | title = The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions | journal = Nature | volume = 427 | issue = 6976 | pages = 749–53 | year = 2004 | pmid = 14973489 | doi = 10.1038/nature02305 }}
*{{cite journal | author=Waltregny D, Alami Y, Clausse N, ''et al.'' |title=Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation. |journal=Prostate |volume=50 |issue= 3 |pages= 162-9 |year= 2002 |pmid= 11813208 |doi= }}
*{{cite journal | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Bayarsaihan D, Enkhmandakh B, Makeyev A, ''et al.'' |title=Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 18 |pages= 10358-63 |year= 2003 |pmid= 12925734 |doi= 10.1073/pnas.1834010100 }}
*{{cite journal | author=Luo L, Yang X, Takihara Y, ''et al.'' |title=The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. |journal=Nature |volume=427 |issue= 6976 |pages= 749-53 |year= 2004 |pmid= 14973489 |doi= 10.1038/nature02305 }}
}}
{{refend}}
{{refend}}


Line 91: Line 41:


{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
{{Transcription factors|g3}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-12-stub}}

Latest revision as of 02:02, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.[1][2][3]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.[3] HOXC8 was found to have activity in promoting nerve growth and its expression is dysregulated in patients suffering from neurofibromatosis type 1.[4]

See also

Interactions

HOXC8 has been shown to interact with Mothers against decapentaplegic homolog 6[5] and Mothers against decapentaplegic homolog 1.[6]

References

  1. ↑ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. ↑ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. ↑ 3.0 3.1 "Entrez Gene: HOXC8 homeobox C8".
  4. ↑ Liu Y, Kang D, Li C, Xu G, Tan Y, Wang J (Jan 2014). "Microarray‑based identification of nerve growth‑promoting genes in neurofibromatosis type I". Mol Med Rep. 9 (1): 192–6. doi:10.3892/mmr.2013.1785. PMID 24213587.
  5. ↑ Bai S, Shi X, Yang X, Cao X (March 2000). "Smad6 as a transcriptional corepressor". J. Biol. Chem. 275 (12): 8267–70. doi:10.1074/jbc.275.12.8267. PMID 10722652.
  6. ↑ Shi X, Yang X, Chen D, Chang Z, Cao X (May 1999). "Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling". J. Biol. Chem. 274 (19): 13711–7. doi:10.1074/jbc.274.19.13711. PMID 10224145.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Retrieved from "https://www.wikidoc.org/index.php?title=HOXC8&oldid=1415749"