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{{Infobox_gene}}
{{PBB_Controls
'''Inhibitor of growth protein 1''' is a [[protein]] that in humans is encoded by the ''ING1'' [[gene]].<ref name="pmid8944021">{{cite journal | vauthors = Garkavtsev I, Kazarov A, Gudkov A, Riabowol K | title = Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation | journal = Nature Genetics | volume = 14 | issue = 4 | pages = 415–20 | date = Dec 1996 | pmid = 8944021 | pmc =  | doi = 10.1038/ng1296-415 }}</ref><ref name="pmid9186514">{{cite journal | vauthors = Garkavtsev I, Demetrick D, Riabowol K | title = Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1) | journal = Cytogenetics and Cell Genetics | volume = 76 | issue = 3-4 | pages = 176–8 | date = Jul 1997 | pmid = 9186514 | pmc =  | doi = 10.1159/000134539 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ING1 inhibitor of growth family, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3621| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Inhibitor of growth family, member 1
| HGNCid = 6062
| Symbol = ING1
| AltSymbols =; p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a
| OMIM = 601566
| ECnumber = 
| Homologene = 40119
| MGIid = 1349481
| GeneAtlas_image1 = PBB_GE_ING1_209808_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_ING1_208415_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_ING1_210350_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3621
    | Hs_Ensembl = ENSG00000153487
    | Hs_RefseqProtein = NP_005528
    | Hs_RefseqmRNA = NM_005537
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 110163084
    | Hs_GenLoc_end = 110171422
    | Hs_Uniprot = Q9UK53
    | Mm_EntrezGene = 26356
    | Mm_Ensembl = ENSMUSG00000045969
    | Mm_RefseqmRNA = XM_976418
    | Mm_RefseqProtein = XP_981512
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 11556038
    | Mm_GenLoc_end = 11563222
    | Mm_Uniprot = Q3ULE3
  }}
}}
'''Inhibitor of growth family, member 1''', also known as '''ING1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ING1 inhibitor of growth family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3621| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: ING1 inhibitor of growth family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3621| accessdate = }}</ref>
}}


==References==
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref name="entrez"/>
{{reflist|2}}


==Further reading==
==Location on Chromosome 13==
ING1 is located near the following genes on [[Chromosome 13]]
*[[CARKD (gene)|CARKD]] Carbohydrate Kinase Domain-Containing Protein (Unknown Function)
* [[COL4A2]]: A2 Subunit of type IV collagen
* [[RAB20]]: Potential regulator of Connexin 43 trafficking.
* [[CARS2]]: Mitochondrial Cystienyl-tRNA Synthetase 2
 
== Interactions ==
 
ING1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[CREB binding protein]],<ref name = pmid12015309/>
* [[DMAP1]],<ref name = pmid14665632>{{cite journal | vauthors = Xin H, Yoon HG, Singh PB, Wong J, Qin J | title = Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells | journal = The Journal of Biological Chemistry | volume = 279 | issue = 10 | pages = 9539–46 | date = Mar 2004 | pmid = 14665632 | doi = 10.1074/jbc.M311587200 }}</ref>
* [[HDAC1]],<ref name = pmid12015309>{{cite journal | vauthors = Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, Pastyryeva S, Meijer M, Johnston RN, Bazett-Jones DP, McMahon S, Cole MD, Young D, Riabowol K | title = Human ING1 proteins differentially regulate histone acetylation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 29832–9 | date = Aug 2002 | pmid = 12015309 | doi = 10.1074/jbc.M200197200 }}</ref><ref name = pmid11784859>{{cite journal | vauthors = Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D | title = Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) | journal = Molecular and Cellular Biology | volume = 22 | issue = 3 | pages = 835–48 | date = Feb 2002 | pmid = 11784859 | pmc = 133546 | doi =  10.1128/mcb.22.3.835-848.2002}}</ref>
* [[P53]],<ref name = pmid12208736>{{cite journal | vauthors = Leung KM, Po LS, Tsang FC, Siu WY, Lau A, Ho HT, Poon RY | title = The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2 | journal = Cancer Research | volume = 62 | issue = 17 | pages = 4890–3 | date = Sep 2002 | pmid = 12208736 | doi =  }}</ref><ref name = pmid9440695>{{cite journal | vauthors = Garkavtsev I, Grigorian IA, Ossovskaya VS, Chernov MV, Chumakov PM, Gudkov AV | title = The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control | journal = Nature | volume = 391 | issue = 6664 | pages = 295–8 | date = Jan 1998 | pmid = 9440695 | doi = 10.1038/34675 }}</ref>
* [[PCNA]],<ref name = pmid11682605>{{cite journal | vauthors = Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K | title = UV-induced binding of ING1 to PCNA regulates the induction of apoptosis | journal = Journal of Cell Science | volume = 114 | issue = Pt 19 | pages = 3455–62 | date = Oct 2001 | pmid = 11682605 | doi =  }}</ref>
* [[SAP30]],<ref name = pmid11784859/>
* [[SIN3A]],<ref name = pmid11784859/>
* [[SMARCA4]],<ref name = pmid11784859/> and
* [[SMARCC1]].<ref name = pmid11784859/>
{{Div col end}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Campos EI, Chin MY, Kuo WH, Li G | title = Biological functions of the ING family tumor suppressors | journal = Cellular and Molecular Life Sciences | volume = 61 | issue = 19-20 | pages = 2597–613 | date = Oct 2004 | pmid = 15526165 | doi = 10.1007/s00018-004-4199-4 }}
| citations =
* {{cite journal | vauthors = Helbing CC, Veillette C, Riabowol K, Johnston RN, Garkavtsev I | title = A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis | journal = Cancer Research | volume = 57 | issue = 7 | pages = 1255–8 | date = Apr 1997 | pmid = 9102209 | doi = }}
*{{cite journal | author=Campos EI, Chin MY, Kuo WH, Li G |title=Biological functions of the ING family tumor suppressors. |journal=Cell. Mol. Life Sci. |volume=61 |issue= 19-20 |pages= 2597-613 |year= 2004 |pmid= 15526165 |doi= 10.1007/s00018-004-4199-4 }}
* {{cite journal | vauthors = Garkavtsev I, Riabowol K | title = Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor | journal = Molecular and Cellular Biology | volume = 17 | issue = 4 | pages = 2014–9 | date = Apr 1997 | pmid = 9121449 | pmc = 232048 | doi =  10.1128/mcb.17.4.2014}}
*{{cite journal | author=Garkavtsev I, Kazarov A, Gudkov A, Riabowol K |title=Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation. |journal=Nat. Genet. |volume=14 |issue= 4 |pages= 415-20 |year= 1997 |pmid= 8944021 |doi= 10.1038/ng1296-415 }}
* {{cite journal | vauthors = Zeremski M, Horrigan SK, Grigorian IA, Westbrook CA, Gudkov AV | title = Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34 | journal = Somatic Cell and Molecular Genetics | volume = 23 | issue = 3 | pages = 233–6 | date = May 1997 | pmid = 9330636 | doi = 10.1007/BF02721376 }}
*{{cite journal | author=Helbing CC, Veillette C, Riabowol K, ''et al.'' |title=A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis. |journal=Cancer Res. |volume=57 |issue= 7 |pages= 1255-8 |year= 1997 |pmid= 9102209 |doi=  }}
* {{cite journal | vauthors = Garkavtsev I, Grigorian IA, Ossovskaya VS, Chernov MV, Chumakov PM, Gudkov AV | title = The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control | journal = Nature | volume = 391 | issue = 6664 | pages = 295–8 | date = Jan 1998 | pmid = 9440695 | doi = 10.1038/34675 }}
*{{cite journal | author=Garkavtsev I, Riabowol K |title=Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 2014-9 |year= 1997 |pmid= 9121449 |doi= }}
* {{cite journal | vauthors = Shinoura N, Muramatsu Y, Nishimura M, Yoshida Y, Saito A, Yokoyama T, Furukawa T, Horii A, Hashimoto M, Asai A, Kirino T, Hamada H | title = Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas | journal = Cancer Research | volume = 59 | issue = 21 | pages = 5521–8 | date = Nov 1999 | pmid = 10554029 | doi =  }}
*{{cite journal | author=Garkavtsev I, Demetrick D, Riabowol K |title=Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1). |journal=Cytogenet. Cell Genet. |volume=76 |issue= 3-4 |pages= 176-8 |year= 1997 |pmid= 9186514 |doi= }}
* {{cite journal | vauthors = Jäger D, Stockert E, Scanlan MJ, Güre AO, Jäger E, Knuth A, Old LJ, Chen YT | title = Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene | journal = Cancer Research | volume = 59 | issue = 24 | pages = 6197–204 | date = Dec 1999 | pmid = 10626813 | doi = }}
*{{cite journal | author=Zeremski M, Horrigan SK, Grigorian IA, ''et al.'' |title=Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34. |journal=Somat. Cell Mol. Genet. |volume=23 |issue= 3 |pages= 233-6 |year= 1997 |pmid= 9330636 |doi=  }}
* {{cite journal | vauthors = Sanchez-Cespedes M, Okami K, Cairns P, Sidransky D | title = Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions | journal = Genes, Chromosomes & Cancer | volume = 27 | issue = 3 | pages = 319–22 | date = Mar 2000 | pmid = 10679922 | doi = 10.1002/(SICI)1098-2264(200003)27:3<319::AID-GCC13>3.0.CO;2-P }}
*{{cite journal | author=Garkavtsev I, Grigorian IA, Ossovskaya VS, ''et al.'' |title=The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control. |journal=Nature |volume=391 |issue= 6664 |pages= 295-8 |year= 1998 |pmid= 9440695 |doi= 10.1038/34675 }}
* {{cite journal | vauthors = Tokunaga E, Maehara Y, Oki E, Kitamura K, Kakeji Y, Ohno S, Sugimachi K | title = Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers | journal = Cancer Letters | volume = 152 | issue = 1 | pages = 15–22 | date = Apr 2000 | pmid = 10754201 | doi = 10.1016/S0304-3835(99)00434-6 }}
*{{cite journal | author=Shinoura N, Muramatsu Y, Nishimura M, ''et al.'' |title=Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas. |journal=Cancer Res. |volume=59 |issue= 21 |pages= 5521-8 |year= 1999 |pmid= 10554029 |doi= }}
* {{cite journal | vauthors = Baranova AV, Ivanov DV, Makeeva NV, Corcoran M, Nikitin EA, Borodina TA, Poltaraus AB, Glinshchikova OA, Sudarikov AB, Oscier D, Iankovskiĭ NK | title = [Genomic organization of the suppressor gene for tumor growth ING1] | journal = Molekuliarnaia Biologiia | volume = 34 | issue = 2 | pages = 263–9 | year = 2000 | pmid = 10779953 | doi =  }}
*{{cite journal | author=Jäger D, Stockert E, Scanlan MJ, ''et al.'' |title=Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene. |journal=Cancer Res. |volume=59 |issue= 24 |pages= 6197-204 |year= 2000 |pmid= 10626813 |doi= }}
* {{cite journal | vauthors = Saito A, Furukawa T, Fukushige S, Koyama S, Hoshi M, Hayashi Y, Horii A | title = p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1 | journal = Journal of Human Genetics | volume = 45 | issue = 3 | pages = 177–81 | year = 2000 | pmid = 10807544 | doi = 10.1007/s100380050206 }}
*{{cite journal | author=Sanchez-Cespedes M, Okami K, Cairns P, Sidransky D |title=Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions. |journal=Genes Chromosomes Cancer |volume=27 |issue= 3 |pages= 319-22 |year= 2000 |pmid= 10679922 |doi=  }}
* {{cite journal | vauthors = Gunduz M, Ouchida M, Fukushima K, Hanafusa H, Etani T, Nishioka S, Nishizaki K, Shimizu K | title = Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas | journal = Cancer Research | volume = 60 | issue = 12 | pages = 3143–6 | date = Jun 2000 | pmid = 10866301 | doi =  }}
*{{cite journal | author=Tokunaga E, Maehara Y, Oki E, ''et al.'' |title=Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers. |journal=Cancer Lett. |volume=152 |issue= 1 |pages= 15-22 |year= 2000 |pmid= 10754201 |doi= }}
* {{cite journal | vauthors = Skowyra D, Zeremski M, Neznanov N, Li M, Choi Y, Uesugi M, Hauser CA, Gu W, Gudkov AV, Qin J | title = Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex | journal = The Journal of Biological Chemistry | volume = 276 | issue = 12 | pages = 8734–9 | date = Mar 2001 | pmid = 11118440 | doi = 10.1074/jbc.M007664200 }}
*{{cite journal | author=Baranova AV, Ivanov DV, Makeeva NV, ''et al.'' |title=[Genomic organization of the suppressor gene for tumor growth ING1] |journal=Mol. Biol. (Mosk.) |volume=34 |issue= 2 |pages= 263-9 |year= 2000 |pmid= 10779953 |doi=  }}
* {{cite journal | vauthors = Nagashima M, Shiseki M, Miura K, Hagiwara K, Linke SP, Pedeux R, Wang XW, Yokota J, Riabowol K, Harris CC | title = DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 17 | pages = 9671–6 | date = Aug 2001 | pmid = 11481424 | pmc = 55510 | doi = 10.1073/pnas.161151798 }}
*{{cite journal | author=Saito A, Furukawa T, Fukushige S, ''et al.'' |title=p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1. |journal=J. Hum. Genet. |volume=45 |issue= 3 |pages= 177-81 |year= 2000 |pmid= 10807544 |doi= }}
* {{cite journal | vauthors = Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K | title = UV-induced binding of ING1 to PCNA regulates the induction of apoptosis | journal = Journal of Cell Science | volume = 114 | issue = Pt 19 | pages = 3455–62 | date = Oct 2001 | pmid = 11682605 | doi = }}
*{{cite journal | author=Gunduz M, Ouchida M, Fukushima K, ''et al.'' |title=Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. |journal=Cancer Res. |volume=60 |issue= 12 |pages= 3143-6 |year= 2000 |pmid= 10866301 |doi= }}
* {{cite journal | vauthors = Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D | title = Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) | journal = Molecular and Cellular Biology | volume = 22 | issue = 3 | pages = 835–48 | date = Feb 2002 | pmid = 11784859 | pmc = 133546 | doi = 10.1128/MCB.22.3.835-848.2002 }}
*{{cite journal | author=Skowyra D, Zeremski M, Neznanov N, ''et al.'' |title=Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 8734-9 |year= 2001 |pmid= 11118440 |doi= 10.1074/jbc.M007664200 }}
* {{cite journal | vauthors = Nouman GS, Angus B, Lunec J, Crosier S, Lodge A, Anderson JJ | title = Comparative assessment expression of the inhibitor of growth 1 gene (ING1) in normal and neoplastic tissues | journal = Hybridoma and Hybridomics | volume = 21 | issue = 1 | pages = 1–10 | date = Feb 2002 | pmid = 11991811 | doi = 10.1089/15368590252917584 }}
*{{cite journal | author=Nagashima M, Shiseki M, Miura K, ''et al.'' |title=DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 17 |pages= 9671-6 |year= 2001 |pmid= 11481424 |doi= 10.1073/pnas.161151798 }}
* {{cite journal | vauthors = Bromidge T, Lynas C | title = Relative levels of alternative transcripts of the ING1 gene and lack of mutations of p33/ING1 in haematological malignancies | journal = Leukemia Research | volume = 26 | issue = 7 | pages = 631–5 | date = Jul 2002 | pmid = 12008079 | doi = 10.1016/S0145-2126(01)00185-0 }}
*{{cite journal | author=Scott M, Bonnefin P, Vieyra D, ''et al.'' |title=UV-induced binding of ING1 to PCNA regulates the induction of apoptosis. |journal=J. Cell. Sci. |volume=114 |issue= Pt 19 |pages= 3455-62 |year= 2001 |pmid= 11682605 |doi= }}
*{{cite journal | author=Kuzmichev A, Zhang Y, Erdjument-Bromage H, ''et al.'' |title=Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). |journal=Mol. Cell. Biol. |volume=22 |issue= 3 |pages= 835-48 |year= 2002 |pmid= 11784859 |doi= }}
*{{cite journal  | author=Nouman GS, Angus B, Lunec J, ''et al.'' |title=Comparative assessment expression of the inhibitor of growth 1 gene (ING1) in normal and neoplastic tissues. |journal=Hybrid. Hybridomics |volume=21 |issue= 1 |pages= 1-10 |year= 2002 |pmid= 11991811 |doi= 10.1089/15368590252917584 }}
*{{cite journal  | author=Bromidge T, Lynas C |title=Relative levels of alternative transcripts of the ING1 gene and lack of mutations of p33/ING1 in haematological malignancies. |journal=Leuk. Res. |volume=26 |issue= 7 |pages= 631-5 |year= 2002 |pmid= 12008079 |doi=  }}
}}
{{refend}}
{{refend}}


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* {{MeshName|ING1+protein,+human}}
* {{MeshName|ING1+protein,+human}}


{{NLM content}}
{{Transcription factors|g2}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 23:52, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.[1][2][3]

Function

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

Location on Chromosome 13

ING1 is located near the following genes on Chromosome 13

  • CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function)
  • COL4A2: A2 Subunit of type IV collagen
  • RAB20: Potential regulator of Connexin 43 trafficking.
  • CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2

Interactions

ING1 has been shown to interact with:

References

  1. ↑ Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (Dec 1996). "Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation". Nature Genetics. 14 (4): 415–20. doi:10.1038/ng1296-415. PMID 8944021.
  2. ↑ Garkavtsev I, Demetrick D, Riabowol K (Jul 1997). "Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)". Cytogenetics and Cell Genetics. 76 (3–4): 176–8. doi:10.1159/000134539. PMID 9186514.
  3. ↑ 3.0 3.1 "Entrez Gene: ING1 inhibitor of growth family, member 1".
  4. ↑ 4.0 4.1 Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, Pastyryeva S, Meijer M, Johnston RN, Bazett-Jones DP, McMahon S, Cole MD, Young D, Riabowol K (Aug 2002). "Human ING1 proteins differentially regulate histone acetylation". The Journal of Biological Chemistry. 277 (33): 29832–9. doi:10.1074/jbc.M200197200. PMID 12015309.
  5. ↑ Xin H, Yoon HG, Singh PB, Wong J, Qin J (Mar 2004). "Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells". The Journal of Biological Chemistry. 279 (10): 9539–46. doi:10.1074/jbc.M311587200. PMID 14665632.
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (Feb 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology. 22 (3): 835–48. doi:10.1128/mcb.22.3.835-848.2002. PMC 133546. PMID 11784859.
  7. ↑ Leung KM, Po LS, Tsang FC, Siu WY, Lau A, Ho HT, Poon RY (Sep 2002). "The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2". Cancer Research. 62 (17): 4890–3. PMID 12208736.
  8. ↑ Garkavtsev I, Grigorian IA, Ossovskaya VS, Chernov MV, Chumakov PM, Gudkov AV (Jan 1998). "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control". Nature. 391 (6664): 295–8. doi:10.1038/34675. PMID 9440695.
  9. ↑ Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K (Oct 2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". Journal of Cell Science. 114 (Pt 19): 3455–62. PMID 11682605.

Further reading

  • Campos EI, Chin MY, Kuo WH, Li G (Oct 2004). "Biological functions of the ING family tumor suppressors". Cellular and Molecular Life Sciences. 61 (19–20): 2597–613. doi:10.1007/s00018-004-4199-4. PMID 15526165.
  • Helbing CC, Veillette C, Riabowol K, Johnston RN, Garkavtsev I (Apr 1997). "A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis". Cancer Research. 57 (7): 1255–8. PMID 9102209.
  • Garkavtsev I, Riabowol K (Apr 1997). "Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor". Molecular and Cellular Biology. 17 (4): 2014–9. doi:10.1128/mcb.17.4.2014. PMC 232048. PMID 9121449.
  • Zeremski M, Horrigan SK, Grigorian IA, Westbrook CA, Gudkov AV (May 1997). "Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34". Somatic Cell and Molecular Genetics. 23 (3): 233–6. doi:10.1007/BF02721376. PMID 9330636.
  • Garkavtsev I, Grigorian IA, Ossovskaya VS, Chernov MV, Chumakov PM, Gudkov AV (Jan 1998). "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control". Nature. 391 (6664): 295–8. doi:10.1038/34675. PMID 9440695.
  • Shinoura N, Muramatsu Y, Nishimura M, Yoshida Y, Saito A, Yokoyama T, Furukawa T, Horii A, Hashimoto M, Asai A, Kirino T, Hamada H (Nov 1999). "Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas". Cancer Research. 59 (21): 5521–8. PMID 10554029.
  • Jäger D, Stockert E, Scanlan MJ, Güre AO, Jäger E, Knuth A, Old LJ, Chen YT (Dec 1999). "Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene". Cancer Research. 59 (24): 6197–204. PMID 10626813.
  • Sanchez-Cespedes M, Okami K, Cairns P, Sidransky D (Mar 2000). "Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions". Genes, Chromosomes & Cancer. 27 (3): 319–22. doi:10.1002/(SICI)1098-2264(200003)27:3<319::AID-GCC13>3.0.CO;2-P. PMID 10679922.
  • Tokunaga E, Maehara Y, Oki E, Kitamura K, Kakeji Y, Ohno S, Sugimachi K (Apr 2000). "Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers". Cancer Letters. 152 (1): 15–22. doi:10.1016/S0304-3835(99)00434-6. PMID 10754201.
  • Baranova AV, Ivanov DV, Makeeva NV, Corcoran M, Nikitin EA, Borodina TA, Poltaraus AB, Glinshchikova OA, Sudarikov AB, Oscier D, Iankovskiĭ NK (2000). "[Genomic organization of the suppressor gene for tumor growth ING1]". Molekuliarnaia Biologiia. 34 (2): 263–9. PMID 10779953.
  • Saito A, Furukawa T, Fukushige S, Koyama S, Hoshi M, Hayashi Y, Horii A (2000). "p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1". Journal of Human Genetics. 45 (3): 177–81. doi:10.1007/s100380050206. PMID 10807544.
  • Gunduz M, Ouchida M, Fukushima K, Hanafusa H, Etani T, Nishioka S, Nishizaki K, Shimizu K (Jun 2000). "Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas". Cancer Research. 60 (12): 3143–6. PMID 10866301.
  • Skowyra D, Zeremski M, Neznanov N, Li M, Choi Y, Uesugi M, Hauser CA, Gu W, Gudkov AV, Qin J (Mar 2001). "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex". The Journal of Biological Chemistry. 276 (12): 8734–9. doi:10.1074/jbc.M007664200. PMID 11118440.
  • Nagashima M, Shiseki M, Miura K, Hagiwara K, Linke SP, Pedeux R, Wang XW, Yokota J, Riabowol K, Harris CC (Aug 2001). "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53". Proceedings of the National Academy of Sciences of the United States of America. 98 (17): 9671–6. doi:10.1073/pnas.161151798. PMC 55510. PMID 11481424.
  • Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K (Oct 2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". Journal of Cell Science. 114 (Pt 19): 3455–62. PMID 11682605.
  • Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (Feb 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology. 22 (3): 835–48. doi:10.1128/MCB.22.3.835-848.2002. PMC 133546. PMID 11784859.
  • Nouman GS, Angus B, Lunec J, Crosier S, Lodge A, Anderson JJ (Feb 2002). "Comparative assessment expression of the inhibitor of growth 1 gene (ING1) in normal and neoplastic tissues". Hybridoma and Hybridomics. 21 (1): 1–10. doi:10.1089/15368590252917584. PMID 11991811.
  • Bromidge T, Lynas C (Jul 2002). "Relative levels of alternative transcripts of the ING1 gene and lack of mutations of p33/ING1 in haematological malignancies". Leukemia Research. 26 (7): 631–5. doi:10.1016/S0145-2126(01)00185-0. PMID 12008079.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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