Estrogen-related receptor beta: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Estrogen-related receptor beta''' ('''ERR-β'''), also known as '''NR3B2''' (nuclear receptor subfamily 3, group B, member 2), is a [[nuclear receptor]] that in humans is encoded by the ''ESRRB'' (EStrogen Related Receptor Beta) [[gene]] .<ref name="entrez">{{cite web | title = Entrez Gene: ESRRB estrogen-related receptor beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2103| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = no
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ESRRB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1lo1.
| PDB = {{PDB2|1lo1}}
| Name = Estrogen-related receptor beta
| HGNCid = 3473
| Symbol = ESRRB
| AltSymbols =; ERR2; ERRb; ERRbeta; ERRbeta-2; ESRL2; NR3B2
| OMIM = 602167
| ECnumber = 
| Homologene = 69108
| MGIid = 1346832
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016439 |text = tRNA-pseudouridine synthase activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2103
    | Hs_Ensembl = ENSG00000119715
    | Hs_RefseqProtein = NP_004443
    | Hs_RefseqmRNA = NM_004452
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 75943634
    | Hs_GenLoc_end = 76036825
    | Hs_Uniprot = O95718
    | Mm_EntrezGene = 26380
    | Mm_Ensembl = ENSMUSG00000021255
    | Mm_RefseqmRNA = NM_011934
    | Mm_RefseqProtein = NP_036064
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 87250220
    | Mm_GenLoc_end = 87410725
    | Mm_Uniprot = Q80VS1
  }}
}}
'''Estrogen-related receptor beta''' ('''ERR-beta'''), also known as '''NR3B2''' (nuclear receptor subfamily 3, group B, member 2), is a [[nuclear receptor]] which is encoded by the gene {{gene|ESRRB}} (EStrogen Related Receptor Beta).<ref name="entrez">{{cite web | title = Entrez Gene: ESRRB estrogen-related receptor beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2103| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein with sequence similarity to the [[estrogen receptor]], a member of [[nuclear receptor|nuclear hormone receptor]]  family of [[steroid hormone receptor]]s. Its function is unknown; however, a similar protein in mouse plays an essential role in [[placenta]]l development.<ref name="entrez">{{cite web | title = Entrez Gene: ESRRB estrogen-related receptor beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2103| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein with sequence similarity to the [[estrogen receptor]], a member of [[nuclear receptor|nuclear hormone receptor]]  family of [[steroid hormone receptor]]s. Its function is unknown; however, a similar protein in mouse plays an essential role in [[placenta]]l development.<ref name="entrez">{{cite web | title = Entrez Gene: ESRRB estrogen-related receptor beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2103| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Giguère V, Yang N, Segui P, Evans RM | title = Identification of a new class of steroid hormone receptors | journal = Nature | volume = 331 | issue = 6151 | pages = 91–4 | date = Jan 1988 | pmid = 3267207 | doi = 10.1038/331091a0 }}
| citations =
* {{cite journal | vauthors = Sladek R, Beatty B, Squire J, Copeland NG, Gilbert DJ, Jenkins NA, Giguère V | title = Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene | journal = Genomics | volume = 45 | issue = 2 | pages = 320–6 | date = Oct 1997 | pmid = 9344655 | doi = 10.1006/geno.1997.4939 }}
*{{cite journal | author=Giguère V, Yang N, Segui P, Evans RM |title=Identification of a new class of steroid hormone receptors. |journal=Nature |volume=331 |issue= 6151 |pages= 91-4 |year= 1988 |pmid= 3267207 |doi= 10.1038/331091a0 }}
* {{cite journal | vauthors = Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjöld M, Gustafsson JA | title = Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 82 | issue = 12 | pages = 4258–65 | date = Dec 1997 | pmid = 9398750 | doi = 10.1210/jc.82.12.4258 }}
*{{cite journal | author=Sladek R, Beatty B, Squire J, ''et al.'' |title=Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene. |journal=Genomics |volume=45 |issue= 2 |pages= 320-6 |year= 1998 |pmid= 9344655 |doi= 10.1006/geno.1997.4939 }}
* {{cite journal | vauthors = Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT | title = Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR | journal = Gene | volume = 228 | issue = 1-2 | pages = 101–9 | date = Mar 1999 | pmid = 10072763 | doi = 10.1016/S0378-1119(98)00619-2 }}
*{{cite journal | author=Enmark E, Pelto-Huikko M, Grandien K, ''et al.'' |title=Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 12 |pages= 4258-65 |year= 1998 |pmid= 9398750 |doi= }}
* {{cite journal | vauthors = Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM | title = Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2 | journal = Molecular Endocrinology | volume = 13 | issue = 12 | pages = 2151–62 | date = Dec 1999 | pmid = 10598588 | doi = 10.1210/me.13.12.2151 }}
*{{cite journal | author=Chen F, Zhang Q, McDonald T, ''et al.'' |title=Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR. |journal=Gene |volume=228 |issue= 1-2 |pages= 101-9 |year= 1999 |pmid= 10072763 |doi= }}
* {{cite journal | vauthors = Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE | title = Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition | journal = Journal of Molecular Biology | volume = 327 | issue = 4 | pages = 819–32 | date = Apr 2003 | pmid = 12654265 | doi = 10.1016/S0022-2836(03)00183-9 }}
*{{cite journal | author=Xie W, Hong H, Yang NN, ''et al.'' |title=Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2. |journal=Mol. Endocrinol. |volume=13 |issue= 12 |pages= 2151-62 |year= 2000 |pmid= 10598588 |doi=  }}
* {{cite journal | vauthors = Kruijver FP, Balesar R, Espila AM, Unmehopa UA, Swaab DF | title = Estrogen-receptor-beta distribution in the human hypothalamus: similarities and differences with ER alpha distribution | journal = The Journal of Comparative Neurology | volume = 466 | issue = 2 | pages = 251–77 | date = Nov 2003 | pmid = 14528452 | doi = 10.1002/cne.10899 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Stossi F, Barnett DH, Frasor J, Komm B, Lyttle CR, Katzenellenbogen BS | title = Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors | journal = Endocrinology | volume = 145 | issue = 7 | pages = 3473–86 | date = Jul 2004 | pmid = 15033914 | doi = 10.1210/en.2003-1682 }}
*{{cite journal  | author=Heilig R, Eckenberg R, Petit JL, ''et al.'' |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601-7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 }}
* {{cite journal | vauthors = Verdier-Sevrain S, Yaar M, Cantatore J, Traish A, Gilchrest BA | title = Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism | journal = FASEB Journal | volume = 18 | issue = 11 | pages = 1252–4 | date = Aug 2004 | pmid = 15208259 | doi = 10.1096/fj.03-1088fje }}
*{{cite journal | author=Gearhart MD, Holmbeck SM, Evans RM, ''et al.'' |title=Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition. |journal=J. Mol. Biol. |volume=327 |issue= 4 |pages= 819-32 |year= 2003 |pmid= 12654265 |doi= }}
* {{cite journal | vauthors = Smith LH, Coats SR, Qin H, Petrie MS, Covington JW, Su M, Eren M, Vaughan DE | title = Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells | journal = Circulation Research | volume = 95 | issue = 3 | pages = 269–75 | date = Aug 2004 | pmid = 15217907 | doi = 10.1161/01.RES.0000136521.70093.f1 }}
*{{cite journal | author=Kruijver FP, Balesar R, Espila AM, ''et al.'' |title=Estrogen-receptor-beta distribution in the human hypothalamus: similarities and differences with ER alpha distribution. |journal=J. Comp. Neurol. |volume=466 |issue= 2 |pages= 251-77 |year= 2003 |pmid= 14528452 |doi= 10.1002/cne.10899 }}
* {{cite journal | vauthors = Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA | title = Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 90 | issue = 2 | pages = 1041–6 | date = Feb 2005 | pmid = 15536156 | doi = 10.1210/jc.2004-1211 }}
*{{cite journal | author=Stossi F, Barnett DH, Frasor J, ''et al.'' |title=Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors. |journal=Endocrinology |volume=145 |issue= 7 |pages= 3473-86 |year= 2004 |pmid= 15033914 |doi= 10.1210/en.2003-1682 }}
* {{cite journal | vauthors = Cheung CP, Yu S, Wong KB, Chan LW, Lai FM, Wang X, Suetsugi M, Chen S, Chan FL | title = Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 90 | issue = 3 | pages = 1830–44 | date = Mar 2005 | pmid = 15598686 | doi = 10.1210/jc.2004-1421 }}
*{{cite journal | author=Verdier-Sevrain S, Yaar M, Cantatore J, ''et al.'' |title=Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism. |journal=FASEB J. |volume=18 |issue= 11 |pages= 1252-4 |year= 2005 |pmid= 15208259 |doi= 10.1096/fj.03-1088fje }}
* {{cite journal | vauthors = Zhou W, Liu Z, Wu J, Liu JH, Hyder SM, Antoniou E, Lubahn DB | title = Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 91 | issue = 2 | pages = 569–79 | date = Feb 2006 | pmid = 16332939 | doi = 10.1210/jc.2004-1957 }}
*{{cite journal | author=Smith LH, Coats SR, Qin H, ''et al.'' |title=Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells. |journal=Circ. Res. |volume=95 |issue= 3 |pages= 269-75 |year= 2005 |pmid= 15217907 |doi= 10.1161/01.RES.0000136521.70093.f1 }}
*{{cite journal | author=Liu PY, Christian RC, Ruan M, ''et al.'' |title=Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 2 |pages= 1041-6 |year= 2005 |pmid= 15536156 |doi= 10.1210/jc.2004-1211 }}
*{{cite journal | author=Cheung CP, Yu S, Wong KB, ''et al.'' |title=Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 3 |pages= 1830-44 |year= 2005 |pmid= 15598686 |doi= 10.1210/jc.2004-1421 }}
*{{cite journal | author=Zhou W, Liu Z, Wu J, ''et al.'' |title=Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta. |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue= 2 |pages= 569-79 |year= 2006 |pmid= 16332939 |doi= 10.1210/jc.2004-1957 }}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{protein-stub}}
{{gene-14-stub}}
{{Transcription factors}}
{{PDB Gallery|geneid=2103}}
{{Transcription factors|g2}}
{{Nuclear receptor ligands}}
 
[[Category:Intracellular receptors]]
[[Category:Intracellular receptors]]
[[Category:Transcription factors]]
[[Category:Transcription factors]]

Latest revision as of 00:44, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Estrogen-related receptor beta (ERR-β), also known as NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (EStrogen Related Receptor Beta) gene .[1]

Function

This gene encodes a protein with sequence similarity to the estrogen receptor, a member of nuclear hormone receptor family of steroid hormone receptors. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ESRRB estrogen-related receptor beta".

Further reading

  • Giguère V, Yang N, Segui P, Evans RM (Jan 1988). "Identification of a new class of steroid hormone receptors". Nature. 331 (6151): 91–4. doi:10.1038/331091a0. PMID 3267207.
  • Sladek R, Beatty B, Squire J, Copeland NG, Gilbert DJ, Jenkins NA, Giguère V (Oct 1997). "Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene". Genomics. 45 (2): 320–6. doi:10.1006/geno.1997.4939. PMID 9344655.
  • Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjöld M, Gustafsson JA (Dec 1997). "Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern". The Journal of Clinical Endocrinology and Metabolism. 82 (12): 4258–65. doi:10.1210/jc.82.12.4258. PMID 9398750.
  • Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT (Mar 1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR". Gene. 228 (1–2): 101–9. doi:10.1016/S0378-1119(98)00619-2. PMID 10072763.
  • Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM (Dec 1999). "Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2". Molecular Endocrinology. 13 (12): 2151–62. doi:10.1210/me.13.12.2151. PMID 10598588.
  • Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE (Apr 2003). "Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition". Journal of Molecular Biology. 327 (4): 819–32. doi:10.1016/S0022-2836(03)00183-9. PMID 12654265.
  • Kruijver FP, Balesar R, Espila AM, Unmehopa UA, Swaab DF (Nov 2003). "Estrogen-receptor-beta distribution in the human hypothalamus: similarities and differences with ER alpha distribution". The Journal of Comparative Neurology. 466 (2): 251–77. doi:10.1002/cne.10899. PMID 14528452.
  • Stossi F, Barnett DH, Frasor J, Komm B, Lyttle CR, Katzenellenbogen BS (Jul 2004). "Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors". Endocrinology. 145 (7): 3473–86. doi:10.1210/en.2003-1682. PMID 15033914.
  • Verdier-Sevrain S, Yaar M, Cantatore J, Traish A, Gilchrest BA (Aug 2004). "Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism". FASEB Journal. 18 (11): 1252–4. doi:10.1096/fj.03-1088fje. PMID 15208259.
  • Smith LH, Coats SR, Qin H, Petrie MS, Covington JW, Su M, Eren M, Vaughan DE (Aug 2004). "Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells". Circulation Research. 95 (3): 269–75. doi:10.1161/01.RES.0000136521.70093.f1. PMID 15217907.
  • Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA (Feb 2005). "Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease". The Journal of Clinical Endocrinology and Metabolism. 90 (2): 1041–6. doi:10.1210/jc.2004-1211. PMID 15536156.
  • Cheung CP, Yu S, Wong KB, Chan LW, Lai FM, Wang X, Suetsugi M, Chen S, Chan FL (Mar 2005). "Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues". The Journal of Clinical Endocrinology and Metabolism. 90 (3): 1830–44. doi:10.1210/jc.2004-1421. PMID 15598686.
  • Zhou W, Liu Z, Wu J, Liu JH, Hyder SM, Antoniou E, Lubahn DB (Feb 2006). "Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta". The Journal of Clinical Endocrinology and Metabolism. 91 (2): 569–79. doi:10.1210/jc.2004-1957. PMID 16332939.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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