NFATC4: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Nuclear factor of activated T-cells, cytoplasmic 4''' is a [[protein]] that in humans is encoded by the ''NFATC4'' [[gene]].<ref name="pmid7749981">{{cite journal | vauthors = Hoey T, Sun YL, Williamson K, Xu X | title = Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins | journal = Immunity | volume = 2 | issue = 5 | pages = 461–72 | date = May 1995 | pmid = 7749981 | pmc =  | doi = 10.1016/1074-7613(95)90027-6 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4776| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
| HGNCid = 7778
| Symbol = NFATC4
| AltSymbols =; NF-ATc4; NFAT3
| OMIM = 602699
| ECnumber = 
| Homologene = 3349
| MGIid = 1920431
| GeneAtlas_image1 = PBB_GE_NFATC4_213345_at_tn.png
| GeneAtlas_image2 = PBB_GE_NFATC4_205897_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0045333 |text = cellular respiration}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4776
    | Hs_Ensembl = ENSG00000100968
    | Hs_RefseqProtein = NP_004545
    | Hs_RefseqmRNA = NM_004554
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 23907094
    | Hs_GenLoc_end = 23918645
    | Hs_Uniprot = Q14934
    | Mm_EntrezGene = 73181
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_023699
    | Mm_RefseqProtein = NP_076188
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4''', also known as '''NFATC4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4776| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.<ref name="entrez">{{cite web | title = Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4776| accessdate = }}</ref>
}}


==See also==
NFAT transcription factors are implicated in breast cancer, more specifically in the process of cell motility at the basis of metastasis formation. Indeed, NFAT3 (NFATc4) is an inhibitor of cell motility by blocking the expression of [[LCN2]].<ref name="pmid20101218">{{cite journal | vauthors = Fougère M, Gaudineau B, Barbier J, Guaddachi F, Feugeas JP, Auboeuf D, Jauliac S | title = NFAT3 transcription factor inhibits breast cancer cell motility by targeting the Lipocalin 2 gene | journal = Oncogene | volume = 29 | issue = 15 | pages = 2292–301 | date = Apr 2010 | pmid = 20101218 | doi = 10.1038/onc.2009.499 }}</ref>
 
== Interactions ==
 
NFATC4 has been shown to [[Protein-protein interaction|interact]] with [[CREB-binding protein]].<ref name="pmid11514544">{{cite journal | vauthors = Yang T, Davis RJ, Chow CW | title = Requirement of two NFATc4 transactivation domains for CBP potentiation | journal = The Journal of Biological Chemistry | volume = 276 | issue = 43 | pages = 39569–76 | date = Oct 2001 | pmid = 11514544 | doi = 10.1074/jbc.M102961200 }}</ref>
 
== See also ==
* [[NFAT]]
* [[NFAT]]


==References==
== References ==
{{reflist|2}}
{{reflist}}
{{Clear}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rao A, Luo C, Hogan PG | title = Transcription factors of the NFAT family: regulation and function | journal = Annual Review of Immunology | volume = 15 | issue =  | pages = 707–47 | year = 1997 | pmid = 9143705 | doi = 10.1146/annurev.immunol.15.1.707 }}
| citations =
* {{cite journal | vauthors = Crabtree GR | title = Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT | journal = Cell | volume = 96 | issue = 5 | pages = 611–4 | date = Mar 1999 | pmid = 10089876 | doi = 10.1016/S0092-8674(00)80571-1 }}
*{{cite journal | author=Rao A, Luo C, Hogan PG |title=Transcription factors of the NFAT family: regulation and function. |journal=Annu. Rev. Immunol. |volume=15 |issue=  |pages= 707-47 |year= 1997 |pmid= 9143705 |doi= 10.1146/annurev.immunol.15.1.707 }}
* {{cite journal | vauthors = Horsley V, Pavlath GK | title = NFAT: ubiquitous regulator of cell differentiation and adaptation | journal = The Journal of Cell Biology | volume = 156 | issue = 5 | pages = 771–4 | date = Mar 2002 | pmid = 11877454 | pmc = 2173310 | doi = 10.1083/jcb.200111073 }}
*{{cite journal | author=Crabtree GR |title=Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. |journal=Cell |volume=96 |issue= 5 |pages= 611-4 |year= 1999 |pmid= 10089876 |doi= }}
* {{cite journal | vauthors = Jabado N, Le Deist F, Fisher A, Hivroz C | title = Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity | journal = European Journal of Immunology | volume = 24 | issue = 11 | pages = 2646–52 | date = Nov 1994 | pmid = 7957556 | doi = 10.1002/eji.1830241112 }}
*{{cite journal | author=Horsley V, Pavlath GK |title=NFAT: ubiquitous regulator of cell differentiation and adaptation. |journal=J. Cell Biol. |volume=156 |issue= 5 |pages= 771-4 |year= 2002 |pmid= 11877454 |doi= 10.1083/jcb.200111073 }}
* {{cite journal | vauthors = Vacca A, Farina M, Maroder M, Alesse E, Screpanti I, Frati L, Gulino A | title = Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif | journal = Biochemical and Biophysical Research Communications | volume = 205 | issue = 1 | pages = 467–74 | date = Nov 1994 | pmid = 7999066 | doi = 10.1006/bbrc.1994.2689 }}
*{{cite journal | author=Hoey T, Sun YL, Williamson K, Xu X |title=Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. |journal=Immunity |volume=2 |issue= 5 |pages= 461-72 |year= 1995 |pmid= 7749981 |doi=  }}
* {{cite journal | vauthors = Di Somma MM, Majolini MB, Burastero SE, Telford JL, Baldari CT | title = Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering | journal = European Journal of Immunology | volume = 26 | issue = 9 | pages = 2181–8 | date = Sep 1996 | pmid = 8814265 | doi = 10.1002/eji.1830260933 }}
*{{cite journal  | author=Jabado N, Le Deist F, Fisher A, Hivroz C |title=Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity. |journal=Eur. J. Immunol. |volume=24 |issue= 11 |pages= 2646-52 |year= 1994 |pmid= 7957556 |doi= }}
* {{cite journal | vauthors = Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN | title = A calcineurin-dependent transcriptional pathway for cardiac hypertrophy | journal = Cell | volume = 93 | issue = 2 | pages = 215–28 | date = Apr 1998 | pmid = 9568714 | doi = 10.1016/S0092-8674(00)81573-1 }}
*{{cite journal | author=Vacca A, Farina M, Maroder M, ''et al.'' |title=Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 1 |pages= 467-74 |year= 1995 |pmid= 7999066 |doi= 10.1006/bbrc.1994.2689 }}
* {{cite journal | vauthors = Aramburu J, Garcia-Cózar F, Raghavan A, Okamura H, Rao A, Hogan PG | title = Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT | journal = Molecular Cell | volume = 1 | issue = 5 | pages = 627–37 | date = Apr 1998 | pmid = 9660947 | doi = 10.1016/S1097-2765(00)80063-5 }}
*{{cite journal | author=Di Somma MM, Majolini MB, Burastero SE, ''et al.'' |title=Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering. |journal=Eur. J. Immunol. |volume=26 |issue= 9 |pages= 2181-8 |year= 1996 |pmid= 8814265 |doi= }}
* {{cite journal | vauthors = Chow CW, Davis RJ | title = Integration of calcium and cyclic AMP signaling pathways by 14-3-3 | journal = Molecular and Cellular Biology | volume = 20 | issue = 2 | pages = 702–12 | date = Jan 2000 | pmid = 10611249 | pmc = 85175 | doi = 10.1128/MCB.20.2.702-712.2000 }}
*{{cite journal | author=Molkentin JD, Lu JR, Antos CL, ''et al.'' |title=A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. |journal=Cell |volume=93 |issue= 2 |pages= 215-28 |year= 1998 |pmid= 9568714 |doi= }}
* {{cite journal | vauthors = Graef IA, Chen F, Chen L, Kuo A, Crabtree GR | title = Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature | journal = Cell | volume = 105 | issue = 7 | pages = 863–75 | date = Jun 2001 | pmid = 11439183 | doi = 10.1016/S0092-8674(01)00396-8 }}
*{{cite journal | author=Aramburu J, Garcia-Cózar F, Raghavan A, ''et al.'' |title=Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. |journal=Mol. Cell |volume=1 |issue= 5 |pages= 627-37 |year= 1998 |pmid= 9660947 |doi= }}
* {{cite journal | vauthors = Yang T, Davis RJ, Chow CW | title = Requirement of two NFATc4 transactivation domains for CBP potentiation | journal = The Journal of Biological Chemistry | volume = 276 | issue = 43 | pages = 39569–76 | date = Oct 2001 | pmid = 11514544 | doi = 10.1074/jbc.M102961200 }}
*{{cite journal | author=Chow CW, Davis RJ |title=Integration of calcium and cyclic AMP signaling pathways by 14-3-3. |journal=Mol. Cell. Biol. |volume=20 |issue= 2 |pages= 702-12 |year= 2000 |pmid= 10611249 |doi= }}
* {{cite journal | vauthors = Yang TT, Xiong Q, Enslen H, Davis RJ, Chow CW | title = Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases | journal = Molecular and Cellular Biology | volume = 22 | issue = 11 | pages = 3892–904 | date = Jun 2002 | pmid = 11997522 | pmc = 133816 | doi = 10.1128/MCB.22.11.3892-3904.2002 }}
*{{cite journal | author=Graef IA, Chen F, Chen L, ''et al.'' |title=Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. |journal=Cell |volume=105 |issue= 7 |pages= 863-75 |year= 2001 |pmid= 11439183 |doi= }}
* {{cite journal | vauthors = Bennasser Y, Badou A, Tkaczuk J, Bahraoui E | title = Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha | journal = Virology | volume = 303 | issue = 1 | pages = 174–80 | date = Nov 2002 | pmid = 12482669 | doi = 10.1006/viro.2002.1676 }}
*{{cite journal | author=Yang T, Davis RJ, Chow CW |title=Requirement of two NFATc4 transactivation domains for CBP potentiation. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 39569-76 |year= 2001 |pmid= 11514544 |doi= 10.1074/jbc.M102961200 }}
* {{cite journal | vauthors = Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR | title = Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons | journal = Cell | volume = 113 | issue = 5 | pages = 657–70 | date = May 2003 | pmid = 12787506 | doi = 10.1016/S0092-8674(03)00390-8 }}
*{{cite journal | author=Yang TT, Xiong Q, Enslen H, ''et al.'' |title=Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. |journal=Mol. Cell. Biol. |volume=22 |issue= 11 |pages= 3892-904 |year= 2002 |pmid= 11997522 |doi= }}
* {{cite journal | vauthors = Lahti AL, Manninen A, Saksela K | title = Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB | journal = Virology | volume = 310 | issue = 1 | pages = 190–6 | date = May 2003 | pmid = 12788643 | doi = 10.1016/S0042-6822(03)00164-8 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. |journal=Virology |volume=303 |issue= 1 |pages= 174-80 |year= 2003 |pmid= 12482669 |doi= }}
*{{cite journal | author=Graef IA, Wang F, Charron F, ''et al.'' |title=Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. |journal=Cell |volume=113 |issue= 5 |pages= 657-70 |year= 2003 |pmid= 12787506 |doi= }}
*{{cite journal | author=Lahti AL, Manninen A, Saksela K |title=Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB. |journal=Virology |volume=310 |issue= 1 |pages= 190-6 |year= 2003 |pmid= 12788643 |doi= }}
}}
{{refend}}
{{refend}}


Line 88: Line 41:
* {{MeshName|NFATC4+protein,+human}}
* {{MeshName|NFATC4+protein,+human}}


{{Transcription factors|g4}}
{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
{{DEFAULTSORT:Nfatc4}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
[[Category:Human proteins]]
 
 
{{gene-14-stub}}

Latest revision as of 12:52, 5 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.[1][2]

Function

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.[2]

NFAT transcription factors are implicated in breast cancer, more specifically in the process of cell motility at the basis of metastasis formation. Indeed, NFAT3 (NFATc4) is an inhibitor of cell motility by blocking the expression of LCN2.[3]

Interactions

NFATC4 has been shown to interact with CREB-binding protein.[4]

See also

References

  1. ↑ Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity. 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID 7749981.
  2. ↑ 2.0 2.1 "Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4".
  3. ↑ Fougère M, Gaudineau B, Barbier J, Guaddachi F, Feugeas JP, Auboeuf D, Jauliac S (Apr 2010). "NFAT3 transcription factor inhibits breast cancer cell motility by targeting the Lipocalin 2 gene". Oncogene. 29 (15): 2292–301. doi:10.1038/onc.2009.499. PMID 20101218.
  4. ↑ Yang T, Davis RJ, Chow CW (Oct 2001). "Requirement of two NFATc4 transactivation domains for CBP potentiation". The Journal of Biological Chemistry. 276 (43): 39569–76. doi:10.1074/jbc.M102961200. PMID 11514544.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=NFATC4&oldid=1416771"