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{{ | '''Hypermethylated in cancer 1 protein''' is a [[protein]] that in humans is encoded by the ''HIC1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HIC1 hypermethylated in cancer 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3090| accessdate = }}</ref> | ||
}} | |||
'''Hypermethylated in cancer 1''' | |||
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==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Chopin V, Leprince D |title=[Chromosome arm 17p13.3: could HIC1 be the one ?] |journal=Med Sci (Paris) |volume=22 |issue= 1 |pages= 54–61 |year= 2006 |pmid= 16386221 |doi=10.1051/medsci/200622154 }} | ||
*{{cite journal | *{{cite journal |vauthors=Wales MM, Biel MA, el Deiry W, etal |title=p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. |journal=Nat. Med. |volume=1 |issue= 6 |pages= 570–7 |year= 1995 |pmid= 7585125 |doi=10.1038/nm0695-570 }} | ||
*{{cite journal | *{{cite journal |vauthors=Fujii H, Biel MA, Zhou W, etal |title=Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer. |journal=Oncogene |volume=16 |issue= 16 |pages= 2159–64 |year= 1998 |pmid= 9572497 |doi= 10.1038/sj.onc.1201976 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Deltour S, Guerardel C, Stehelin D, Leprince D |title=The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved. |journal=Biochim. Biophys. Acta |volume=1443 |issue= 1-2 |pages= 230–2 |year= 1999 |pmid= 9838134 |doi= 10.1016/s0167-4781(98)00219-x}} | ||
*{{cite journal | | *{{cite journal |vauthors=Deltour S, Guerardel C, Leprince D |title=Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 26 |pages= 14831–6 |year= 2000 |pmid= 10611298 |doi=10.1073/pnas.96.26.14831 | pmc=24733 }} | ||
*{{cite journal | *{{cite journal |vauthors=Guerardel C, Deltour S, Pinte S, etal |title=Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53. |journal=J. Biol. Chem. |volume=276 |issue= 5 |pages= 3078–89 |year= 2001 |pmid= 11073960 |doi= 10.1074/jbc.M008690200 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Deltour S, Pinte S, Guérardel C, Leprince D |title=Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 2 |pages= 427–34 |year= 2001 |pmid= 11554746 |doi= 10.1006/bbrc.2001.5624 }} | ||
*{{cite journal | *{{cite journal |vauthors=Deltour S, Pinte S, Guerardel C, etal |title=The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4890–901 |year= 2002 |pmid= 12052894 |doi=10.1128/MCB.22.13.4890-4901.2002 | pmc=133903 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Cardoso C, Leventer RJ, Ward HL, etal |title=Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3. |journal=Am. J. Hum. Genet. |volume=72 |issue= 4 |pages= 918–30 |year= 2003 |pmid= 12621583 |doi=10.1086/374320 | pmc=1180354 }} | ||
*{{cite journal | *{{cite journal |vauthors=Rathi A, Virmani AK, Harada K, etal |title=Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms. |journal=Clin. Cancer Res. |volume=9 |issue= 10 Pt 1 |pages= 3674–8 |year= 2004 |pmid= 14506157 |doi= }} | ||
*{{cite journal | *{{cite journal |vauthors=Waha A, Waha A, Koch A, etal |title=Epigenetic silencing of the HIC-1 gene in human medulloblastomas. |journal=J. Neuropathol. Exp. Neurol. |volume=62 |issue= 11 |pages= 1192–201 |year= 2004 |pmid= 14656076 |doi= }} | ||
*{{cite journal | *{{cite journal |vauthors=Lindsey JC, Lusher ME, Anderton JA, etal |title=Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling. |journal=Carcinogenesis |volume=25 |issue= 5 |pages= 661–8 |year= 2004 |pmid= 14688019 |doi= 10.1093/carcin/bgh055 }} | ||
*{{cite journal | *{{cite journal |vauthors=Pinte S, Guérardel C, Deltour-Balerdi S, etal |title=Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1. |journal=Oncogene |volume=23 |issue= 22 |pages= 4023–31 |year= 2004 |pmid= 15007385 |doi= 10.1038/sj.onc.1207504 }} | ||
*{{cite journal | *{{cite journal |vauthors=Pinte S, Stankovic-Valentin N, Deltour S, etal |title=The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties. |journal=J. Biol. Chem. |volume=279 |issue= 37 |pages= 38313–24 |year= 2004 |pmid= 15231840 |doi= 10.1074/jbc.M401610200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Chen W, Cooper TK, Zahnow CA, etal |title=Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. |journal=Cancer Cell |volume=6 |issue= 4 |pages= 387–98 |year= 2004 |pmid= 15488761 |doi= 10.1016/j.ccr.2004.08.030 }} | ||
*{{cite journal | *{{cite journal |vauthors=Britschgi C, Rizzi M, Grob TJ, etal |title=Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1. |journal=Oncogene |volume=25 |issue= 14 |pages= 2030–9 |year= 2006 |pmid= 16301995 |doi= 10.1038/sj.onc.1209240 }} | ||
*{{cite journal | *{{cite journal |vauthors=Valenta T, Lukas J, Doubravska L, etal |title=HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. |journal=EMBO J. |volume=25 |issue= 11 |pages= 2326–37 |year= 2006 |pmid= 16724116 |doi= 10.1038/sj.emboj.7601147 | pmc=1478201 }} | ||
*{{cite journal | *{{cite journal |vauthors=Stankovic-Valentin N, Verger A, Deltour-Balerdi S, etal |title=A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. |journal=FEBS J. |volume=273 |issue= 13 |pages= 2879–90 |year= 2006 |pmid= 16762039 |doi= 10.1111/j.1742-4658.2006.05301.x }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
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* {{MeshName|HIC1+protein,+human}} | * {{MeshName|HIC1+protein,+human}} | ||
{{NLM content}} | |||
{{Transcription factors|g2}} | |||
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[[Category:Transcription factors]] | [[Category:Transcription factors]] | ||
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{{gene-17-stub}} |
Latest revision as of 13:35, 31 August 2017
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External IDs | GeneCards: [1] | ||||||
Orthologs | |||||||
Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.[1]
References
Further reading
- Chopin V, Leprince D (2006). "[Chromosome arm 17p13.3: could HIC1 be the one ?]". Med Sci (Paris). 22 (1): 54–61. doi:10.1051/medsci/200622154. PMID 16386221.
- Wales MM, Biel MA, el Deiry W, et al. (1995). "p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3". Nat. Med. 1 (6): 570–7. doi:10.1038/nm0695-570. PMID 7585125.
- Fujii H, Biel MA, Zhou W, et al. (1998). "Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer". Oncogene. 16 (16): 2159–64. doi:10.1038/sj.onc.1201976. PMID 9572497.
- Deltour S, Guerardel C, Stehelin D, Leprince D (1999). "The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved". Biochim. Biophys. Acta. 1443 (1–2): 230–2. doi:10.1016/s0167-4781(98)00219-x. PMID 9838134.
- Deltour S, Guerardel C, Leprince D (2000). "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14831–6. doi:10.1073/pnas.96.26.14831. PMC 24733. PMID 10611298.
- Guerardel C, Deltour S, Pinte S, et al. (2001). "Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53". J. Biol. Chem. 276 (5): 3078–89. doi:10.1074/jbc.M008690200. PMID 11073960.
- Deltour S, Pinte S, Guérardel C, Leprince D (2001). "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1". Biochem. Biophys. Res. Commun. 287 (2): 427–34. doi:10.1006/bbrc.2001.5624. PMID 11554746.
- Deltour S, Pinte S, Guerardel C, et al. (2002). "The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif". Mol. Cell. Biol. 22 (13): 4890–901. doi:10.1128/MCB.22.13.4890-4901.2002. PMC 133903. PMID 12052894.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3". Am. J. Hum. Genet. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583.
- Rathi A, Virmani AK, Harada K, et al. (2004). "Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms". Clin. Cancer Res. 9 (10 Pt 1): 3674–8. PMID 14506157.
- Waha A, Waha A, Koch A, et al. (2004). "Epigenetic silencing of the HIC-1 gene in human medulloblastomas". J. Neuropathol. Exp. Neurol. 62 (11): 1192–201. PMID 14656076.
- Lindsey JC, Lusher ME, Anderton JA, et al. (2004). "Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling". Carcinogenesis. 25 (5): 661–8. doi:10.1093/carcin/bgh055. PMID 14688019.
- Pinte S, Guérardel C, Deltour-Balerdi S, et al. (2004). "Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1". Oncogene. 23 (22): 4023–31. doi:10.1038/sj.onc.1207504. PMID 15007385.
- Pinte S, Stankovic-Valentin N, Deltour S, et al. (2004). "The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties". J. Biol. Chem. 279 (37): 38313–24. doi:10.1074/jbc.M401610200. PMID 15231840.
- Chen W, Cooper TK, Zahnow CA, et al. (2004). "Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis". Cancer Cell. 6 (4): 387–98. doi:10.1016/j.ccr.2004.08.030. PMID 15488761.
- Britschgi C, Rizzi M, Grob TJ, et al. (2006). "Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1". Oncogene. 25 (14): 2030–9. doi:10.1038/sj.onc.1209240. PMID 16301995.
- Valenta T, Lukas J, Doubravska L, et al. (2006). "HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies". EMBO J. 25 (11): 2326–37. doi:10.1038/sj.emboj.7601147. PMC 1478201. PMID 16724116.
- Stankovic-Valentin N, Verger A, Deltour-Balerdi S, et al. (2006). "A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP". FEBS J. 273 (13): 2879–90. doi:10.1111/j.1742-4658.2006.05301.x. PMID 16762039.
External links
- HIC1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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