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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger protein 43''' is a [[protein]] that in humans is encoded by the ''ZNF43'' [[gene]].<ref name="pmid1711675">{{cite journal | vauthors = Lovering R, Trowsdale J | title = A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines | journal = Nucleic Acids Research | volume = 19 | issue = 11 | pages = 2921–8 | date = Jun 1991 | pmid = 1711675 | pmc = 328252 | doi = 10.1093/nar/19.11.2921 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZNF43 zinc finger protein 43| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7594| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Zinc finger protein 43
| HGNCid = 13109
| Symbol = ZNF43
| AltSymbols =; AURKA; ARK1; AURORA2; BTAK; STK15; KOX27; DKFZp686L1854; HTF6; ZNF39L1
| OMIM = 603972
| ECnumber = 
| Homologene = 86693
| MGIid = 3040691
| GeneAtlas_image1 = PBB_GE_ZNF43_206695_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_ZNF43_217547_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_ZNF43_222136_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7594
    | Hs_Ensembl = ENSG00000198521
    | Hs_RefseqProtein = NP_003414
    | Hs_RefseqmRNA = NM_003423
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 21779594
    | Hs_GenLoc_end = 21810810
    | Hs_Uniprot = P17038
    | Mm_EntrezGene = 238690
    | Mm_Ensembl = ENSMUSG00000055480
    | Mm_RefseqmRNA = NM_001001152
    | Mm_RefseqProtein = NP_001001152
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 67755212
    | Mm_GenLoc_end = 67759346
    | Mm_Uniprot = 
  }}
}}
'''Zinc finger protein 43''', also known as '''ZNF43''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZNF43 zinc finger protein 43| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7594| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions.<ref name="entrez">{{cite web | title = Entrez Gene: ZNF43 zinc finger protein 43| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7594| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Zinc finger]]
* [[Zinc finger]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Huebner K, Druck T, Croce CM, Thiesen HJ | title = Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering | journal = American Journal of Human Genetics | volume = 48 | issue = 4 | pages = 726–40 | date = Apr 1991 | pmid = 2014798 | pmc = 1682948 | doi =  }}
| citations =
* {{cite journal | vauthors = Bellefroid EJ, Poncelet DA, Lecocq PJ, Revelant O, Martial JA | title = The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 9 | pages = 3608–12 | date = May 1991 | pmid = 2023909 | pmc = 51501 | doi = 10.1073/pnas.88.9.3608 }}
*{{cite journal | author=Lovering R, Trowsdale J |title=A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines. |journal=Nucleic Acids Res. |volume=19 |issue= 11 |pages= 2921-8 |year= 1991 |pmid= 1711675 |doi=  }}
* {{cite journal | vauthors = Thiesen HJ | title = Multiple genes encoding zinc finger domains are expressed in human T cells | journal = The New Biologist | volume = 2 | issue = 4 | pages = 363–74 | date = Apr 1990 | pmid = 2288909 | doi =  }}
*{{cite journal  | author=Huebner K, Druck T, Croce CM, Thiesen HJ |title=Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. |journal=Am. J. Hum. Genet. |volume=48 |issue= 4 |pages= 726-40 |year= 1991 |pmid= 2014798 |doi=  }}
* {{cite journal | vauthors = Bellefroid EJ, Marine JC, Ried T, Lecocq PJ, Rivière M, Amemiya C, Poncelet DA, Coulie PG, de Jong P, Szpirer C | title = Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells | journal = The EMBO Journal | volume = 12 | issue = 4 | pages = 1363–74 | date = Apr 1993 | pmid = 8467795 | pmc = 413348 | doi =  }}
*{{cite journal | author=Bellefroid EJ, Poncelet DA, Lecocq PJ, ''et al.'' |title=The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 9 |pages= 3608-12 |year= 1991 |pmid= 2023909 |doi= }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Thiesen HJ |title=Multiple genes encoding zinc finger domains are expressed in human T cells. |journal=New Biol. |volume=2 |issue= 4 |pages= 363-74 |year= 1991 |pmid= 2288909 |doi=  }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
*{{cite journal | author=Bellefroid EJ, Marine JC, Ried T, ''et al.'' |title=Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. |journal=EMBO J. |volume=12 |issue= 4 |pages= 1363-74 |year= 1993 |pmid= 8467795 |doi=  }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415–8 | date = Jan 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Takahashi T, Furuchi T, Naganuma A | title = Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells | journal = Cancer Research | volume = 66 | issue = 24 | pages = 11932–7 | date = Dec 2006 | pmid = 17178891 | doi = 10.1158/0008-5472.CAN-06-3220 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Takahashi T, Furuchi T, Naganuma A |title=Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells. |journal=Cancer Res. |volume=66 |issue= 24 |pages= 11932-7 |year= 2007 |pmid= 17178891 |doi= 10.1158/0008-5472.CAN-06-3220 }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
{{Transcription factors|g2}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-19-stub}}

Latest revision as of 01:13, 19 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger protein 43 is a protein that in humans is encoded by the ZNF43 gene.[1][2]

Function

This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions.[2]

See also

References

  1. ↑ Lovering R, Trowsdale J (Jun 1991). "A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines". Nucleic Acids Research. 19 (11): 2921–8. doi:10.1093/nar/19.11.2921. PMC 328252. PMID 1711675.
  2. ↑ 2.0 2.1 "Entrez Gene: ZNF43 zinc finger protein 43".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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