SOX18: Difference between revisions
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{{ | '''Transcription factor SOX-18''' is a [[protein]] that in humans is encoded by the ''SOX18'' [[gene]].<ref name="pmid10807548">{{cite journal | vauthors = Azuma T, Seki N, Yoshikawa T, Saito T, Masuho Y, Muramatsu M | title = cDNA cloning, tissue expression, and chromosome mapping of human homolog of SOX18 | journal = J. Hum. Genet. | volume = 45 | issue = 3 | pages = 192–5 | date = July 2000 | pmid = 10807548 | pmc = | doi = 10.1007/s100380050210 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SO X18 SRY (sex determining region Y)-box 18| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54345| accessdate = }}</ref> | ||
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== Function == | |||
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of [[hypotrichosis]]-[[lymphedema]]-[[telangiectasia]].<ref name="entrez" /> | |||
==See also== | == Interactions == | ||
SOX18 has been shown to [[Protein-protein interaction|interact]] with [[MEF2C]].<ref name=pmid11554755>{{cite journal | vauthors = Hosking BM, Wang SC, Chen SL, Penning S, Koopman P, Muscat GE | title = SOX18 directly interacts with MEF2C in endothelial cells | journal = Biochem. Biophys. Res. Commun. | volume = 287 | issue = 2 | pages = 493–500 | date = September 2001 | pmid = 11554755 | doi = 10.1006/bbrc.2001.5589 }}</ref> | |||
== See also == | |||
* [[SOX genes]] | * [[SOX genes]] | ||
==References== | == References == | ||
{{ | {{Reflist}} | ||
==Further reading== | == Further reading == | ||
{{ | {{Refbegin | 2}} | ||
* {{cite journal | vauthors = Wilson M, Koopman P | title = Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators | journal = Curr. Opin. Genet. Dev. | volume = 12 | issue = 4 | pages = 441–6 | year = 2002 | pmid = 12100890 | doi = 10.1016/S0959-437X(02)00323-4 }} | |||
* {{cite journal | vauthors = Schepers GE, Teasdale RD, Koopman P | title = Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families | journal = Dev. Cell | volume = 3 | issue = 2 | pages = 167–70 | year = 2002 | pmid = 12194848 | doi = 10.1016/S1534-5807(02)00223-X }} | |||
*{{cite journal | * {{cite journal | vauthors = Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A | title = A conserved family of genes related to the testis determining gene, SRY | journal = Nucleic Acids Res. | volume = 20 | issue = 11 | pages = 2887 | year = 1992 | pmid = 1614875 | pmc = 336939 | doi = 10.1093/nar/20.11.2887 }} | ||
*{{cite journal | * {{cite journal | vauthors = Dunn TL, Mynett-Johnson L, Wright EM, Hosking BM, Koopman PA, Muscat GE | title = Sequence and expression of Sox-18 encoding a new HMG-box transcription factor | journal = Gene | volume = 161 | issue = 2 | pages = 223–5 | year = 1995 | pmid = 7665083 | doi = 10.1016/0378-1119(95)00280-J }} | ||
*{{cite journal | * {{cite journal | vauthors = Stanojcić S, Stevanović M | title = The human SOX18 gene: cDNA cloning and high resolution mapping | journal = Biochim. Biophys. Acta | volume = 1492 | issue = 1 | pages = 237–41 | year = 2000 | pmid = 10858556 | doi = 10.1016/s0167-4781(00)00078-6 }} | ||
*{{cite journal | * {{cite journal | vauthors = Pennisi DJ, James KM, Hosking B, Muscat GE, Koopman P | title = Structure, mapping, and expression of human SOX18 | journal = Mamm. Genome | volume = 11 | issue = 12 | pages = 1147–9 | year = 2000 | pmid = 11130989 | doi = 10.1007/s003350010216 }} | ||
* {{cite journal | vauthors = Hosking BM, Wang SC, Chen SL, Penning S, Koopman P, Muscat GE | title = SOX18 directly interacts with MEF2C in endothelial cells | journal = Biochem. Biophys. Res. Commun. | volume = 287 | issue = 2 | pages = 493–500 | year = 2001 | pmid = 11554755 | doi = 10.1006/bbrc.2001.5589 }} | |||
*{{cite journal | * {{cite journal | vauthors = Dintilhac A, Bernués J | title = HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences | journal = J. Biol. Chem. | volume = 277 | issue = 9 | pages = 7021–8 | year = 2002 | pmid = 11748221 | doi = 10.1074/jbc.M108417200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Saitoh T, Katoh M | title = Expression of human SOX18 in normal tissues and tumors | journal = Int. J. Mol. Med. | volume = 10 | issue = 3 | pages = 339–44 | year = 2002 | pmid = 12165811 | doi = 10.3892/ijmm.10.3.339 }} | ||
*{{cite journal | * {{cite journal | vauthors = Irrthum A, Devriendt K, Chitayat D, Matthijs G, Glade C, Steijlen PM, Fryns JP, Van Steensel MA, Vikkula M | title = Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia | journal = Am. J. Hum. Genet. | volume = 72 | issue = 6 | pages = 1470–8 | year = 2003 | pmid = 12740761 | pmc = 1180307 | doi = 10.1086/375614 }} | ||
*{{cite journal | * {{cite journal | vauthors = García-Ramírez M, Martínez-González J, Juan-Babot JO, Rodríguez C, Badimon L | title = Transcription factor SOX18 is expressed in human coronary atherosclerotic lesions and regulates DNA synthesis and vascular cell growth | journal = Arterioscler. Thromb. Vasc. Biol. | volume = 25 | issue = 11 | pages = 2398–403 | year = 2005 | pmid = 16179596 | doi = 10.1161/01.ATV.0000187464.81959.23 }} | ||
*{{cite journal | * {{cite journal | vauthors = Young N, Hahn CN, Poh A, Dong C, Wilhelm D, Olsson J, Muscat GE, Parsons P, Gamble JR, Koopman P | title = Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development | journal = J. Natl. Cancer Inst. | volume = 98 | issue = 15 | pages = 1060–7 | year = 2006 | pmid = 16882943 | doi = 10.1093/jnci/djj299 }} | ||
{{Refend}} | |||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{ | |||
== External links == | == External links == | ||
* {{MeshName|SOX18+protein,+human}} | * {{MeshName|SOX18+protein,+human}} | ||
{{NLM content}} | |||
{{Transcription factors|g4}} | |||
[[Category:Transcription factors]] | [[Category:Transcription factors]] | ||
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{{Gene-20-stub}} |
Latest revision as of 06:51, 11 September 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
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Transcription factor SOX-18 is a protein that in humans is encoded by the SOX18 gene.[1][2]
Function
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.[2]
Interactions
SOX18 has been shown to interact with MEF2C.[3]
See also
References
- ↑ Azuma T, Seki N, Yoshikawa T, Saito T, Masuho Y, Muramatsu M (July 2000). "cDNA cloning, tissue expression, and chromosome mapping of human homolog of SOX18". J. Hum. Genet. 45 (3): 192–5. doi:10.1007/s100380050210. PMID 10807548.
- ↑ 2.0 2.1 "Entrez Gene: SO X18 SRY (sex determining region Y)-box 18".
- ↑ Hosking BM, Wang SC, Chen SL, Penning S, Koopman P, Muscat GE (September 2001). "SOX18 directly interacts with MEF2C in endothelial cells". Biochem. Biophys. Res. Commun. 287 (2): 493–500. doi:10.1006/bbrc.2001.5589. PMID 11554755.
Further reading
- Wilson M, Koopman P (2002). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Curr. Opin. Genet. Dev. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
- Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Dev. Cell. 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
- Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A (1992). "A conserved family of genes related to the testis determining gene, SRY". Nucleic Acids Res. 20 (11): 2887. doi:10.1093/nar/20.11.2887. PMC 336939. PMID 1614875.
- Dunn TL, Mynett-Johnson L, Wright EM, Hosking BM, Koopman PA, Muscat GE (1995). "Sequence and expression of Sox-18 encoding a new HMG-box transcription factor". Gene. 161 (2): 223–5. doi:10.1016/0378-1119(95)00280-J. PMID 7665083.
- Stanojcić S, Stevanović M (2000). "The human SOX18 gene: cDNA cloning and high resolution mapping". Biochim. Biophys. Acta. 1492 (1): 237–41. doi:10.1016/s0167-4781(00)00078-6. PMID 10858556.
- Pennisi DJ, James KM, Hosking B, Muscat GE, Koopman P (2000). "Structure, mapping, and expression of human SOX18". Mamm. Genome. 11 (12): 1147–9. doi:10.1007/s003350010216. PMID 11130989.
- Hosking BM, Wang SC, Chen SL, Penning S, Koopman P, Muscat GE (2001). "SOX18 directly interacts with MEF2C in endothelial cells". Biochem. Biophys. Res. Commun. 287 (2): 493–500. doi:10.1006/bbrc.2001.5589. PMID 11554755.
- Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.
- Saitoh T, Katoh M (2002). "Expression of human SOX18 in normal tissues and tumors". Int. J. Mol. Med. 10 (3): 339–44. doi:10.3892/ijmm.10.3.339. PMID 12165811.
- Irrthum A, Devriendt K, Chitayat D, Matthijs G, Glade C, Steijlen PM, Fryns JP, Van Steensel MA, Vikkula M (2003). "Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia". Am. J. Hum. Genet. 72 (6): 1470–8. doi:10.1086/375614. PMC 1180307. PMID 12740761.
- García-Ramírez M, Martínez-González J, Juan-Babot JO, Rodríguez C, Badimon L (2005). "Transcription factor SOX18 is expressed in human coronary atherosclerotic lesions and regulates DNA synthesis and vascular cell growth". Arterioscler. Thromb. Vasc. Biol. 25 (11): 2398–403. doi:10.1161/01.ATV.0000187464.81959.23. PMID 16179596.
- Young N, Hahn CN, Poh A, Dong C, Wilhelm D, Olsson J, Muscat GE, Parsons P, Gamble JR, Koopman P (2006). "Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development". J. Natl. Cancer Inst. 98 (15): 1060–7. doi:10.1093/jnci/djj299. PMID 16882943.
External links
- SOX18+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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