MYT1: Difference between revisions

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Latest revision as of 03:16, 27 October 2017

Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.^[1]^[2]^[3]

Function

The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.^[3]

Interactive pathway map

Click on genes, proteins and metabolites below to visit related articles. ^{[§ 1]}

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<imagemap> Image:WP3584.png

|{{{bSize}}}px|alt=MECP2 and associated Rett Syndrome edit]]

MECP2 and associated Rett Syndrome edit

↑ The interactive pathway map can be edited at WikiPathways: "WP3584".

Interactions

MYT1 has been shown to interact with PIN1.^[4]

References

↑ Kim JG, Hudson LD (Dec 1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene". Molecular and Cellular Biology. 12 (12): 5632–9. doi:10.1128/mcb.12.12.5632. PMC 360502. PMID 1280325.
↑ Booher RN, Holman PS, Fattaey A (Aug 1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". The Journal of Biological Chemistry. 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380.
↑ ^3.0 ^3.1 "Entrez Gene: MYT1 myelin transcription factor 1".
↑ Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T (Oct 1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". Journal of Cell Science. 112 (19): 3361–71. PMID 10504341.

Gogate N, Verma L, Zhou JM, Milward E, Rusten R, O'Connor M, Kufta C, Kim J, Hudson L, Dubois-Dalcq M (Aug 1994). "Plasticity in the adult human oligodendrocyte lineage". The Journal of Neuroscience. 14 (8): 4571–87. PMID 7519254.
Armstrong RC, Kim JG, Hudson LD (Aug 1995). "Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes". Glia. 14 (4): 303–21. doi:10.1002/glia.440140407. PMID 8530187.
Liu F, Stanton JJ, Wu Z, Piwnica-Worms H (Feb 1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex". Molecular and Cellular Biology. 17 (2): 571–83. doi:10.1128/mcb.17.2.571. PMC 231782. PMID 9001210.
Kim JG, Armstrong RC, v Agoston D, Robinsky A, Wiese C, Nagle J, Hudson LD (Oct 1997). "Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system". Journal of Neuroscience Research. 50 (2): 272–90. doi:10.1002/(SICI)1097-4547(19971015)50:2<272::AID-JNR16>3.0.CO;2-A. PMID 9373037.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
Hirayama A, Oka A, Ito M, Tanaka F, Okoshi Y, Takashima S (Jan 2003). "Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia". Brain Research. Developmental Brain Research. 140 (1): 85–92. doi:10.1016/S0165-3806(02)00585-0. PMID 12524179.
Nielsen JA, Berndt JA, Hudson LD, Armstrong RC (Jan 2004). "Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells". Molecular and Cellular Neurosciences. 25 (1): 111–23. doi:10.1016/j.mcn.2003.10.001. PMID 14962745.
Vana AC, Lucchinetti CF, Le TQ, Armstrong RC (May 2007). "Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS". Glia. 55 (7): 687–97. doi:10.1002/glia.20492. PMC 2789289. PMID 17330875.

External links

MYT1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[WikiPathways-4] The interactive pathway map can be edited at WikiPathways: "WP3584".

[pmid1280325-1] Kim JG, Hudson LD (Dec 1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene". Molecular and Cellular Biology. 12 (12): 5632–9. doi:10.1128/mcb.12.12.5632. PMC 360502. PMID 1280325.

[pmid9268380-2] Booher RN, Holman PS, Fattaey A (Aug 1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". The Journal of Biological Chemistry. 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380.

[entrez-3] 3.0 ^3.1 "Entrez Gene: MYT1 myelin transcription factor 1".

[pmid10504341-5] Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T (Oct 1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". Journal of Cell Science. 112 (19): 3361–71. PMID 10504341.

[1]

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[§ 1]

[4]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Use dmy dates|date=April 2013}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Myelin transcription factor 1''' is a [[protein]] that in humans is encoded by the ''MYT1'' [[gene]].<ref name="pmid1280325">{{cite journal | vauthors = Kim JG, Hudson LD | title = Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene | journal = Molecular and Cellular Biology | volume = 12 | issue = 12 | pages = 5632–9 | date = Dec 1992 | pmid = 1280325 | pmc = 360502 | doi =  10.1128/mcb.12.12.5632}}</ref><ref name="pmid9268380">{{cite journal | vauthors = Booher RN, Holman PS, Fattaey A | title = Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity | journal = The Journal of Biological Chemistry | volume = 272 | issue = 35 | pages = 22300–6 | date = Aug 1997 | pmid = 9268380 | pmc =  | doi = 10.1074/jbc.272.35.22300 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MYT1 myelin transcription factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4661| accessdate = }}</ref>
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Myelin transcription factor 1
- | HGNCid = 7622
- | Symbol = MYT1
- | AltSymbols =; MTF1; C20orf36; MYTI; PLPB1
- | OMIM = 600379
- | ECnumber =
- | Homologene = 3332
- | MGIid = 1100535
- | GeneAtlas_image1 = PBB_GE_MYT1_210341_at_tn.png
- | GeneAtlas_image2 = PBB_GE_MYT1_215822_x_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 4661
-    | Hs_Ensembl = ENSG00000196132
-    | Hs_RefseqProtein = NP_004526
-    | Hs_RefseqmRNA = NM_004535
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 20
-    | Hs_GenLoc_start = 62253588
-    | Hs_GenLoc_end = 62344048
-    | Hs_Uniprot = Q01538
-    | Mm_EntrezGene = 17932
-    | Mm_Ensembl = ENSMUSG00000010505
-    | Mm_RefseqmRNA = NM_008665
-    | Mm_RefseqProtein = NP_032691
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 2
-    | Mm_GenLoc_start = 181718928
-    | Mm_GenLoc_end = 181755450
-    | Mm_Uniprot = Q3UXY0
-  }}
-}}
-'''Myelin transcription factor 1''', also known as '''MYT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYT1 myelin transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4661| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.<ref name="entrez">{{cite web | title = Entrez Gene: MYT1 myelin transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4661| accessdate = }}</ref>
-}}
-==References==
+== Interactive pathway map ==
-{{reflist|2}}
+{{MECP2andAssociatedRettSyndrome_WP3584|highlight=MYT1}}
-==Further reading==
+== Interactions ==
+MYT1 has been shown to [[Protein-protein interaction|interact]] with [[PIN1]].<ref name=pmid10504341>{{cite journal | vauthors = Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T | title = The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression | journal = Journal of Cell Science | volume = 112 | issue = 19 | pages = 3361–71 | date = Oct 1999 | pmid = 10504341 }}</ref>
+== References ==
+{{reflist}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Gogate N, Verma L, Zhou JM, Milward E, Rusten R, O'Connor M, Kufta C, Kim J, Hudson L, Dubois-Dalcq M | title = Plasticity in the adult human oligodendrocyte lineage | journal = The Journal of Neuroscience | volume = 14 | issue = 8 | pages = 4571–87 | date = Aug 1994 | pmid = 7519254 | doi =  }}
-| citations =
+* {{cite journal | vauthors = Armstrong RC, Kim JG, Hudson LD | title = Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes | journal = Glia | volume = 14 | issue = 4 | pages = 303–21 | date = Aug 1995 | pmid = 8530187 | doi = 10.1002/glia.440140407 }}
-*{{cite journal  | author=Kim JG, Hudson LD |title=Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene. |journal=Mol. Cell. Biol. |volume=12 |issue= 12 |pages= 5632-9 |year= 1992 |pmid= 1280325 |doi=  }}
+* {{cite journal | vauthors = Liu F, Stanton JJ, Wu Z, Piwnica-Worms H | title = The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex | journal = Molecular and Cellular Biology | volume = 17 | issue = 2 | pages = 571–83 | date = Feb 1997 | pmid = 9001210 | pmc = 231782 | doi =  10.1128/mcb.17.2.571}}
-*{{cite journal  | author=Gogate N, Verma L, Zhou JM, ''et al.'' |title=Plasticity in the adult human oligodendrocyte lineage. |journal=J. Neurosci. |volume=14 |issue= 8 |pages= 4571-87 |year= 1994 |pmid= 7519254 |doi=  }}
+* {{cite journal | vauthors = Kim JG, Armstrong RC, v Agoston D, Robinsky A, Wiese C, Nagle J, Hudson LD | title = Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system | journal = Journal of Neuroscience Research | volume = 50 | issue = 2 | pages = 272–90 | date = Oct 1997 | pmid = 9373037 | doi = 10.1002/(SICI)1097-4547(19971015)50:2<272::AID-JNR16>3.0.CO;2-A }}
-*{{cite journal  | author=Armstrong RC, Kim JG, Hudson LD |title=Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes. |journal=Glia |volume=14 |issue= 4 |pages= 303-21 |year= 1996 |pmid= 8530187 |doi= 10.1002/glia.440140407 }}
+* {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 6 | pages = 355–64 | date = Dec 1998 | pmid = 10048485 | doi = 10.1093/dnares/5.6.355 }}
-*{{cite journal  | author=Liu F, Stanton JJ, Wu Z, Piwnica-Worms H |title=The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. |journal=Mol. Cell. Biol. |volume=17 |issue= 2 |pages= 571-83 |year= 1997 |pmid= 9001210 |doi=  }}
+* {{cite journal | vauthors = Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 6 | issue = 3 | pages = 197–205 | date = Jun 1999 | pmid = 10470851 | doi = 10.1093/dnares/6.3.197 }}
-*{{cite journal  | author=Kim JG, Armstrong RC, v Agoston D, ''et al.'' |title=Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. |journal=J. Neurosci. Res. |volume=50 |issue= 2 |pages= 272-90 |year= 1998 |pmid= 9373037 |doi=  }}
+* {{cite journal | vauthors = Hirayama A, Oka A, Ito M, Tanaka F, Okoshi Y, Takashima S | title = Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia | journal = Brain Research. Developmental Brain Research | volume = 140 | issue = 1 | pages = 85–92 | date = Jan 2003 | pmid = 12524179 | doi = 10.1016/S0165-3806(02)00585-0 }}
-*{{cite journal  | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355-64 |year= 1999 |pmid= 10048485 |doi=  }}
+* {{cite journal | vauthors = Nielsen JA, Berndt JA, Hudson LD, Armstrong RC | title = Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells | journal = Molecular and Cellular Neurosciences | volume = 25 | issue = 1 | pages = 111–23 | date = Jan 2004 | pmid = 14962745 | doi = 10.1016/j.mcn.2003.10.001 }}
-*{{cite journal  | author=Kikuno R, Nagase T, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi=  }}
+* {{cite journal | vauthors = Vana AC, Lucchinetti CF, Le TQ, Armstrong RC | title = Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS | journal = Glia | volume = 55 | issue = 7 | pages = 687–97 | date = May 2007 | pmid = 17330875 | pmc = 2789289 | doi = 10.1002/glia.20492 }}
-*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Hirayama A, Oka A, Ito M, ''et al.'' |title=Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia. |journal=Brain Res. Dev. Brain Res. |volume=140 |issue= 1 |pages= 85-92 |year= 2003 |pmid= 12524179 |doi=  }}
-*{{cite journal  | author=Nielsen JA, Berndt JA, Hudson LD, Armstrong RC |title=Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells. |journal=Mol. Cell. Neurosci. |volume=25 |issue= 1 |pages= 111-23 |year= 2004 |pmid= 14962745 |doi= 10.1016/j.mcn.2003.10.001 }}
-*{{cite journal  | author=Vana AC, Lucchinetti CF, Le TQ, Armstrong RC |title=Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS. |journal=Glia |volume=55 |issue= 7 |pages= 687-97 |year= 2007 |pmid= 17330875 |doi= 10.1002/glia.20492 }}
-}}
 {{refend}}
@@ Line 79: / Line 33: @@
 * {{MeshName|MYT1+protein,+human}}
+{{NLM content}}
+{{Transcription factors|g2}}
-{{protein-stub}}
-{{NLM content}}
-{{Transcription factors}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}
+{{gene-20-stub}}