BACH1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS (v470))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Transcription regulator protein BACH1''' is a [[protein]] that in humans is encoded by the ''BACH1'' [[gene]].<ref name="pmid9544839">{{cite journal | vauthors = Blouin JL, Duriaux Saïl G, Guipponi M, Rossier C, Pappasavas MP, Antonarakis SE | title = Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1 | journal = Human Genetics | volume = 102 | issue = 3 | pages = 282–8 | date = Mar 1998 | pmid = 9544839 | pmc =  | doi = 10.1007/s004390050692 }}</ref><ref name="pmid9479503">{{cite journal | vauthors = Ohira M, Seki N, Nagase T, Ishikawa K, Nomura N, Ohara O | title = Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1 | journal = Genomics | volume = 47 | issue = 2 | pages = 300–6 | date = Jan 1998 | pmid = 9479503 | pmc = | doi = 10.1006/geno.1997.5080 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=571| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_BACH1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ihc.
| PDB = {{PDB2|2ihc}}
| Name = BTB and CNC homology 1, basic leucine zipper transcription factor 1
| HGNCid = 935
| Symbol = BACH1
| AltSymbols =;
| OMIM = 602751
| ECnumber = 
| Homologene = 916
| MGIid = 894680
| GeneAtlas_image1 = PBB_GE_BACH1_204194_at_tn.png
| GeneAtlas_image2 = PBB_GE_BACH1_210818_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 571
    | Hs_Ensembl = ENSG00000156273
    | Hs_RefseqProtein = NP_001011545
    | Hs_RefseqmRNA = NM_001011545
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 21
    | Hs_GenLoc_start = 29593091
    | Hs_GenLoc_end = 29645921
    | Hs_Uniprot = O14867
    | Mm_EntrezGene = 12013
    | Mm_Ensembl = ENSMUSG00000025612
    | Mm_RefseqmRNA = XM_001004169
    | Mm_RefseqProtein = XP_001004169
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 87588150
    | Mm_GenLoc_end = 87622542
    | Mm_Uniprot = Q3URL4
  }}
}}
'''BTB and CNC homology 1, basic leucine zipper transcription factor 1''', also known as '''BACH1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=571| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region [[leucine zipper]] factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These [[BTB/POZ domain]]s facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. The C-terminus of the protein is a leucine zipper of the [[BZIP Maf|bzip_maf]] family. When this protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of this gene overlap with some exons from the C21orf41 gene, which is transcribed in an opposite orientation to this gene but does not seem to encode a protein.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of this gene overlap with some exons from the C21orf41 gene, which is transcribed in an opposite orientation to this gene but does not seem to encode a protein.<ref name="entrez">{{cite web | title = Entrez Gene: BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=571| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Ozono R | title = New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway | journal = Current Pharmaceutical Biotechnology | volume = 7 | issue = 2 | pages = 87–93 | date = Apr 2006 | pmid = 16724942 | doi = 10.2174/138920106776597630 }}
| citations =
* {{cite journal | vauthors = Oyake T, Itoh K, Motohashi H, Hayashi N, Hoshino H, Nishizawa M, Yamamoto M, Igarashi K | title = Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site | journal = Molecular and Cellular Biology | volume = 16 | issue = 11 | pages = 6083–95 | date = Nov 1996 | pmid = 8887638 | pmc = 231611 | doi = 10.1128/mcb.16.11.6083 }}
*{{cite journal | author=Ozono R |title=New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway. |journal=Current pharmaceutical biotechnology |volume=7 |issue= 2 |pages= 87-93 |year= 2006 |pmid= 16724942 |doi= }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Oyake T, Itoh K, Motohashi H, ''et al.'' |title=Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. |journal=Mol. Cell. Biol. |volume=16 |issue= 11 |pages= 6083-95 |year= 1996 |pmid= 8887638 |doi= }}
* {{cite journal | vauthors = Kobayashi A, Yamagiwa H, Hoshino H, Muto A, Sato K, Morita M, Hayashi N, Yamamoto M, Igarashi K | title = A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain | journal = Molecular and Cellular Biology | volume = 20 | issue = 5 | pages = 1733–46 | date = Mar 2000 | pmid = 10669750 | pmc = 85356 | doi = 10.1128/MCB.20.5.1733-1746.2000 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Kanezaki R, Toki T, Yokoyama M, Yomogida K, Sugiyama K, Yamamoto M, Igarashi K, Ito E | title = Transcription factor BACH1 is recruited to the nucleus by its novel alternative spliced isoform | journal = The Journal of Biological Chemistry | volume = 276 | issue = 10 | pages = 7278–84 | date = Mar 2001 | pmid = 11069897 | doi = 10.1074/jbc.M004227200 }}
*{{cite journal  | author=Ohira M, Seki N, Nagase T, ''et al.'' |title=Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1. |journal=Genomics |volume=47 |issue= 2 |pages= 300-6 |year= 1998 |pmid= 9479503 |doi=  }}
* {{cite journal | vauthors = Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S, Wahrer DC, Sgroi DC, Lane WS, Haber DA, Livingston DM | title = BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function | journal = Cell | volume = 105 | issue = 1 | pages = 149–60 | date = Apr 2001 | pmid = 11301010 | doi = 10.1016/S0092-8674(01)00304-X }}
*{{cite journal  | author=Blouin JL, Duriaux Saïl G, Guipponi M, ''et al.'' |title=Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1. |journal=Hum. Genet. |volume=102 |issue= 3 |pages= 282-8 |year= 1998 |pmid= 9544839 |doi=  }}
* {{cite journal | vauthors = Kitamuro T, Takahashi K, Ogawa K, Udono-Fujimori R, Takeda K, Furuyama K, Nakayama M, Sun J, Fujita H, Hida W, Hattori T, Shirato K, Igarashi K, Shibahara S | title = Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells | journal = The Journal of Biological Chemistry | volume = 278 | issue = 11 | pages = 9125–33 | date = Mar 2003 | pmid = 12511571 | doi = 10.1074/jbc.M209939200 }}
*{{cite journal | author=Kobayashi A, Yamagiwa H, Hoshino H, ''et al.'' |title=A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1733-46 |year= 2000 |pmid= 10669750 |doi= }}
* {{cite journal | vauthors = Suzuki H, Tashiro S, Sun J, Doi H, Satomi S, Igarashi K | title = Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene | journal = The Journal of Biological Chemistry | volume = 278 | issue = 49 | pages = 49246–53 | date = Dec 2003 | pmid = 14504288 | doi = 10.1074/jbc.M306764200 }}
*{{cite journal  | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
* {{cite journal | vauthors = Tahara T, Sun J, Nakanishi K, Yamamoto M, Mori H, Saito T, Fujita H, Igarashi K, Taketani S | title = Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5480–7 | date = Feb 2004 | pmid = 14660636 | doi = 10.1074/jbc.M302733200 }}
*{{cite journal | author=Kanezaki R, Toki T, Yokoyama M, ''et al.'' |title=Transcription factor BACH1 is recruited to the nucleus by its novel alternative spliced isoform. |journal=J. Biol. Chem. |volume=276 |issue= 10 |pages= 7278-84 |year= 2001 |pmid= 11069897 |doi= 10.1074/jbc.M004227200 }}
* {{cite journal | vauthors = Shim KS, Ferrando-Miguel R, Lubec G | title = Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimer's disease | journal = Journal of Neural Transmission. Supplementum | volume = | issue = 67 | pages = 39–49 | year = 2004 | pmid = 15068237 | doi = 10.1007/978-3-7091-6721-2_3 }}
*{{cite journal | author=Cantor SB, Bell DW, Ganesan S, ''et al.'' |title=BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. |journal=Cell |volume=105 |issue= 1 |pages= 149-60 |year= 2001 |pmid= 11301010 |doi= }}
* {{cite journal | vauthors = Ferrando-Miguel R, Cheon MS, Yang JW, Lubec G | title = Overexpression of transcription factor BACH1 in fetal Down syndrome brain | journal = Journal of Neural Transmission. Supplementum | volume = | issue = 67 | pages = 193–205 | year = 2004 | pmid = 15068251 | doi = 10.1007/978-3-7091-6721-2_17 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Suzuki H, Tashiro S, Hira S, Sun J, Yamazaki C, Zenke Y, Ikeda-Saito M, Yoshida M, Igarashi K | title = Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1 | journal = The EMBO Journal | volume = 23 | issue = 13 | pages = 2544–53 | date = Jul 2004 | pmid = 15175654 | pmc = 449764 | doi = 10.1038/sj.emboj.7600248 }}
*{{cite journal | author=Kitamuro T, Takahashi K, Ogawa K, ''et al.'' |title=Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells. |journal=J. Biol. Chem. |volume=278 |issue= 11 |pages= 9125-33 |year= 2003 |pmid= 12511571 |doi= 10.1074/jbc.M209939200 }}
* {{cite journal | vauthors = Tahara T, Sun J, Igarashi K, Taketani S | title = Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells | journal = Biochemical and Biophysical Research Communications | volume = 324 | issue = 1 | pages = 77–85 | date = Nov 2004 | pmid = 15464985 | doi = 10.1016/j.bbrc.2004.09.022 }}
*{{cite journal | author=Suzuki H, Tashiro S, Sun J, ''et al.'' |title=Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene. |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49246-53 |year= 2004 |pmid= 14504288 |doi= 10.1074/jbc.M306764200 }}
* {{cite journal | vauthors = Shan Y, Lambrecht RW, Ghaziani T, Donohue SE, Bonkovsky HL | title = Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS | journal = The Journal of Biological Chemistry | volume = 279 | issue = 50 | pages = 51769–74 | date = Dec 2004 | pmid = 15465821 | doi = 10.1074/jbc.M409463200 }}
*{{cite journal | author=Tahara T, Sun J, Nakanishi K, ''et al.'' |title=Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5480-7 |year= 2004 |pmid= 14660636 |doi= 10.1074/jbc.M302733200 }}
* {{cite journal | vauthors = Toki T, Katsuoka F, Kanezaki R, Xu G, Kurotaki H, Sun J, Kamio T, Watanabe S, Tandai S, Terui K, Yagihashi S, Komatsu N, Igarashi K, Yamamoto M, Ito E | title = Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment | journal = Blood | volume = 105 | issue = 8 | pages = 3100–8 | date = Apr 2005 | pmid = 15613547 | doi = 10.1182/blood-2004-07-2826 }}
*{{cite journal | author=Shim KS, Ferrando-Miguel R, Lubec G |title=Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimer's disease. |journal=J. Neural Transm. Suppl. |volume= |issue= 67 |pages= 39-49 |year= 2004 |pmid= 15068237 |doi= }}
*{{cite journal | author=Ferrando-Miguel R, Cheon MS, Yang JW, Lubec G |title=Overexpression of transcription factor BACH1 in fetal Down syndrome brain. |journal=J. Neural Transm. Suppl. |volume= |issue= 67 |pages= 193-205 |year= 2004 |pmid= 15068251 |doi= }}
*{{cite journal | author=Suzuki H, Tashiro S, Hira S, ''et al.'' |title=Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1. |journal=EMBO J. |volume=23 |issue= 13 |pages= 2544-53 |year= 2005 |pmid= 15175654 |doi= 10.1038/sj.emboj.7600248 }}
*{{cite journal | author=Tahara T, Sun J, Igarashi K, Taketani S |title=Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 1 |pages= 77-85 |year= 2004 |pmid= 15464985 |doi= 10.1016/j.bbrc.2004.09.022 }}
*{{cite journal | author=Shan Y, Lambrecht RW, Ghaziani T, ''et al.'' |title=Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS. |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 51769-74 |year= 2005 |pmid= 15465821 |doi= 10.1074/jbc.M409463200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Toki T, Katsuoka F, Kanezaki R, ''et al.'' |title=Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment. |journal=Blood |volume=105 |issue= 8 |pages= 3100-8 |year= 2005 |pmid= 15613547 |doi= 10.1182/blood-2004-07-2826 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|BACH1+protein,+human}}
* {{MeshName|BACH1+protein,+human}}
* {{UCSC gene info|BACH1}}
{{NLM content}}
{{PDB Gallery|geneid=571}}
{{Transcription factors|g1}}


[[Category:Transcription factors]]


{{gene-21-stub}}
{{gene-21-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 01:58, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.[1][2][3]

Function

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. The C-terminus of the protein is a leucine zipper of the bzip_maf family. When this protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of this gene overlap with some exons from the C21orf41 gene, which is transcribed in an opposite orientation to this gene but does not seem to encode a protein.[3]

References

  1. ↑ Blouin JL, Duriaux Saïl G, Guipponi M, Rossier C, Pappasavas MP, Antonarakis SE (Mar 1998). "Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1". Human Genetics. 102 (3): 282–8. doi:10.1007/s004390050692. PMID 9544839.
  2. ↑ Ohira M, Seki N, Nagase T, Ishikawa K, Nomura N, Ohara O (Jan 1998). "Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1". Genomics. 47 (2): 300–6. doi:10.1006/geno.1997.5080. PMID 9479503.
  3. ↑ 3.0 3.1 "Entrez Gene: BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=BACH1&oldid=1419814"